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Effects of polyamine analogs on the extent and fidelity of in vitro polypeptide synthesis.

Abstract：

:A series of polyamine analogs has been examined for their ability to support protein synthesis in an in vitro rabbit reticulocyte translation system. Diamines were found to stimulate protein synthesis to the greatest extent (8-12 fold). Triamines, tetraamines and pentaamines only stimulated 2-4 fold under these conditions although much lower concentrations were required. At elevated temperatures (45 degrees C), diamines were somewhat more active than at lower temperature but activity of longer chain polyamines was elevated very significantly. Polyamines with terminal benzyl or smaller alkyl groups had diminished activity. It is concluded that both charge and charge distribution determine the ability of polyamines to stimulate translation. Fidelity studies identified two classes of polyamines: those which are able to lower the optimal Mg2+ concentration required for amino acid misincorporation while not affecting extent of misincorporation relative to Mg2+ alone, and those which are sparing for Mg2+ and also stimulate extent of misincorporation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Snyder RD,Edwards ML

doi

10.1016/0006-291x(91)90440-i

subject

Has Abstract

pub_date

1991-05-15 00:00:00

pages

1383-92

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90440-I

journal_volume

176

pub_type

杂志文章

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