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A defective prostaglandin E synthase could affect egg formation in the silkworm Bombyx mori.

Abstract：

:We had previously reported a prostaglandin E synthase (bmPGES) in the silkworm Bombyx mori that catalyzes the isomerization of PGH2 to PGE2. The present study aimed to provide a genome-editing characterization of bmPGES in B. mori. Results showed bmPGES gene disruption to result in a reduced content of PGE2. The change affected the expression of chorion genes and egg formation in silkworms. Collectively, the results indicated that bmPGES could be involved in reproduction of B. mori. Therefore, this study provides insights into the physiological role of bmPGES and PGE2 in silkworms.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamamoto K,Tsubota T,Uno T,Tsujita Y,Yokota S,Sezutsu H,Mita K

doi

10.1016/j.bbrc.2019.10.121

subject

Has Abstract

pub_date

2020-01-08 00:00:00

pages

347-352

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)32023-6

journal_volume

521

pub_type

杂志文章

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