当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori.

Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori.

Abstract：

:In the Krebs cycle of Helicobacter pylori, the absence of alpha-ketoglutarate dehydrogenase and succinyl CoA synthetase are shown. Instead, alpha-ketoglutarate is converted to succinyl CoA and succinate by alpha-ketoglutarate oxidoreductase (KOR) and CoA transferase (CoAT). In the present study, when H. pylori transformed to the coccoid form, a viable but non-culturable form of H. pylori with reduced metabolic activity, the KOR activity was enhanced while the CoAT activity was reduced. Direct inactivation of KOR could potently kill the bacteria without allowing conversion to the coccoid form, suggesting a novel treatment strategy for the eradication of H. pylori, especially in cases infected with multiple antibiotic-resistant strains.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tsugawa H,Suzuki H,Nakagawa I,Nishizawa T,Saito Y,Suematsu M,Hibi T

doi

10.1016/j.bbrc.2008.08.078

subject

Has Abstract

pub_date

2008-11-07 00:00:00

pages

46-51

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01624-0

journal_volume

376

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.

    abstract：:Gastric inhibitory polypeptide (GIP) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. Although the GIP receptor is known to be expressed in small intestine, the effects of GIP in small intestine are not fully understood. This study was designed to clarif...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.11.077

    authors： Ogawa E,Hosokawa M,Harada N,Yamane S,Hamasaki A,Toyoda K,Fujimoto S,Fujita Y,Fukuda K,Tsukiyama K,Yamada Y,Seino Y,Inagaki N

    更新日期：2011-01-07 00:00:00

  • TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes.

    abstract：:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.12.039

    authors： Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

    更新日期：2014-01-10 00:00:00

  • ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.

    abstract：:The cis-regulatory region of target genes is key elements in the transcriptional regulation of gene expression. Many of these cis-regulatory regions have not been identified by either biological experiments or computational methods. Recently, a few additional C(2)H(2) zinc finger transcription factor binding sites hav...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.02.106

    authors： Cho SY,Chung M,Park M,Park S,Lee YS

    更新日期：2008-05-09 00:00:00

  • Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer.

    abstract：:Although cancer patients initially respond well to chemotherapy, they eventually develop resistance and relapse. In this work, we demonstrate that eIF4E-targeting therapy is a potential sensitizing strategy for overcoming chemoresistance and progression in cancer. We show that ribavirin, an anti-viral drug and pharmac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.150

    authors： Xi C,Wang L,Yu J,Ye H,Cao L,Gong Z

    更新日期：2018-09-18 00:00:00

  • Production of soluble integrin alpha2beta1 heterodimer complex functionally active in vitro and in vivo.

    abstract：:Integrin alpha2beta1, which is a membrane protein consisting of noncovalently bound alpha2 and beta1 chains, mediates cell binding to collagen and plays a role in platelet functions. DNAs encoding the chimeric proteins in which the extracellular domains of each alpha2 and beta1 chain was fused to hinge and Fc regions ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6195

    authors： Kainoh M,Tanaka T

    更新日期：2002-01-11 00:00:00

  • An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer.

    abstract：:The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with no...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.011

    authors： Kim SJ,Ju JS,Park SS,Suh YA,Yoo HJ,Choi EK,Seong-Yun Jeong,Shin Y,Park YY

    更新日期：2020-07-23 00:00:00

  • Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.

    abstract：:T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive to ponatinib (PNT). However, the novel strategy is required to reduce life-threatening adverse effects of PNT including i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.165

    authors： Inoue C,Sobue S,Kawamoto Y,Nishizawa Y,Ichihara M,Abe A,Hayakawa F,Suzuki M,Nozawa Y,Murate T

    更新日期：2020-05-14 00:00:00

  • Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

    abstract：:Mammary gland-distributed and ER-bound UDP-glucuronosyltransferase (UGT)-2B7 metabolizes genotoxic catechol-estrogens (CE) associated with breast cancer initiation. Although UGT2B7 has 3 PKC- and 2 tyrosine kinase (TK)-sites, its inhibition by genistein, herbimycin-A and PP2 with parallel losses in phospho-tyrosine an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.03.054

    authors： Mitra PS,Basu NK,Owens IS

    更新日期：2009-05-15 00:00:00

  • Synthesis and initial characterization of gamma-L-glutamyl-L-thiothreonylglycine and gamma-L-glutamyl-L-allo-thiothreonylglycine as steric probes of the active site of glyoxalase I.

    abstract：:The diastereomeric GSH derivatives gamma-L-Glu-L-allo-thioThr-Gly (6) and gamma-L-Glu-L-thioThr-Gly (6a) have been synthesized as specific probes of the steric environment near the cysteinyl residue of enzyme bound glutathionyl substrates. Experiments with glyoxalase I indicate that while 6a-methylglyoxal thiohemiacet...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91975-i

    authors： Xie XF,Creighton DJ

    更新日期：1991-05-31 00:00:00

  • High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.

    abstract：:The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1858

    authors： Hiroishi G,Kobayashi S,Nishimura J,Inomata H,Kanaide H

    更新日期：1995-06-15 00:00:00

  • Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.

    abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.012

    authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

    更新日期：2007-11-23 00:00:00

  • Targeting mitochondrial respiration as a therapeutic strategy for cervical cancer.

    abstract：:Targeting mitochondrial respiration has been documented as an effective therapeutic strategy in cancer. However, the impact of mitochondrial respiration inhibition on cervical cancer cells are not well elucidated. Using a panel of cervical cancer cell lines, we show that an existing drug atovaquone is active against t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.042

    authors： Tian S,Chen H,Tan W

    更新日期：2018-05-23 00:00:00

  • Down-regulation of Barx2 predicts poor survival in colorectal cancer.

    abstract：:Human BarH-like homeobox 2 (Barx2), a homeodomain factor of the Bar family, has an important role in controlling the expression of cell adhesion molecules and has been reported in an increasing array of tumor types except colorectal cancer (CRC). The purpose of the current study was to characterize the expression of B...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.091

    authors： Mi Y,Zhao S,Zhang W,Zhang D,Weng J,Huang K,Sun H,Tang H,Zhang X,Sun X,Peng Z,Wen Y

    更新日期：2016-09-09 00:00:00

  • Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma.

    abstract：:Autophagy is a physiologically regulated and evolutionary conserved process that plays a critical role in degradation of cytoplasmic proteins and other macromolecules within the lysosomes. Beclin-1, the mammalian orthologue of yeast Atg6, is an important mediator of autophagy that has been studied in many human cancer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.079

    authors： Kapoor V,Paliwal D,Baskar Singh S,Mohanti BK,Das SN

    更新日期：2012-06-15 00:00:00

  • Participation of macrophage membrane rafts in Trypanosoma cruzi invasion process.

    abstract：:Membrane rafts are small and dynamic regions enriched in sphingolipids, cholesterol, ganglioside GM1 and protein markers like flotillins, forming the flatter domains or caveolins, which are characterized as stable flask-shape invaginations. We explored whether membrane rafts participate in the entry of Trypanosoma cru...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.068

    authors： Barrias ES,Dutra JM,De Souza W,Carvalho TM

    更新日期：2007-11-23 00:00:00

  • Genetic characterization of an Escherichia coli mutant deficient in organophosphonate biodegradation.

    abstract：:An E. coli mutant deficient in organophosphonate biodegradation has been complemented with a cosmid library prepared from a BamHI partial digest of wild-type E. coli W3110. Mutant E. coli SL724, when transformed with cosmid pSL163 and plasmid pSL263, regained the ability to exploit ethylphosphonate as a sole source of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91088-6

    authors： Loo SH,Peters NK,Frost JW

    更新日期：1987-10-14 00:00:00

  • Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes.

    abstract：:Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. Mast cells mature locally; thus, tissue-specific influences are important for promoting mast cell accumulation and survival in t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.04.141

    authors： Cho KA,Park M,Kim YH,Woo SY

    更新日期：2017-06-10 00:00:00

  • Cdc2 activation is not required for thymocyte apoptosis.

    abstract：:Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2086

    authors： Norbury C,MacFarlane M,Fearnhead H,Cohen GM

    更新日期：1994-08-15 00:00:00

  • Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor.

    abstract：:Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade tumor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.161

    authors： Hamdi HK,Castellon R

    更新日期：2005-09-02 00:00:00

  • Identification of structural domains affecting transactivation potential of Nm23.

    abstract：:The strong transactivation activity of the C-terminal half (amino acids 76-152) of Nm23 was reported previously. Here we examined a structural domain preventing or necessary to its transactivation activity. The C-terminal 1/4 (amino acids 109-152) was sufficient for transactivation, but the C-terminal half with a long...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6042

    authors： Cho SJ,Lee NS,Jung YS,Lee H,Lee KJ,Kim E,Chae SK

    更新日期：2001-12-07 00:00:00

  • Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.

    abstract：:p8 is an 80 amino-acid polypeptide identified because of its remarkable over-expression in the stressed pancreas. This protein, apparently devoid of enzymatic activity, is a powerful regulator of several intracellular pathways, suggesting that it has to interact with several molecular partners to modulate their activi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.018

    authors： Malicet C,Hoffmeister A,Moreno S,Closa D,Dagorn JC,Vasseur S,Iovanna JL

    更新日期：2006-01-06 00:00:00

  • Difference in chromatin packaging between active and inactive X chromosomes by fractionation and allele-specific detection.

    abstract：:Using a novel method consisting of chromatin fractionation and allele-specific detection, chromatin packaging is compared between active X (Xa) and inactive X (Xi) chromosomes for five tumor cell clones that were derived from inter-subspecific F1 female mice. Separation of heterochromatic (H) and euchromatic (E) fract...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8201

    authors： Endo Y,Watanabe T,Kuwabara K,Tsunashima K,Mishima Y,Arakawa M,Takagi N,Kominami R

    更新日期：1998-03-06 00:00:00

  • DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.

    abstract：:SAMHD1 (Sterile alpha motif and histidine-aspartic acid (HD) domain containing protein 1) is a deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase (dNTPase) that restricts viral replication in infected cells. This protein is also involved in DNA repair by assisting in DNA end resection by homologous recombinat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.03.225

    authors： Medeiros AC,Soares CS,Coelho PO,Vieira NA,Baqui MMA,Teixeira FR,Gomes MD

    更新日期：2018-05-23 00:00:00

  • Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells.

    abstract：:Cellular defects which prevent apoptotic cell death can result in the generation of hyperproliferative disorders and can prevent the effective treatment of such diseases. The majority of cellular defects which result in apoptosis resistance lie upstream of caspase activation. We have described chimeric caspase molecul...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4699

    authors： Shearwin-Whyatt L,Baliga B,Doumanis J,Kumar S

    更新日期：2001-04-20 00:00:00

  • The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer.

    abstract：:PHF8 is a JmjC domain-containing protein and erases repressive histone marks including H4K20me1 and H3K9me1/2. It binds to H3K4me3, an active histone mark usually located at transcription start sites (TSSs), through its plant homeo-domain, and is thus recruited and enriched in gene promoters. PHF8 is involved in the d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.07.076

    authors： Shen Y,Pan X,Zhao H

    更新日期：2014-08-15 00:00:00

  • High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex.

    abstract：:Botulinum neurotoxins (BoNTs) are produced as progenitor toxin complexes (PTCs) by Clostridium botulinum. The PTCs are composed of BoNT and non-toxic neurotoxin-associated proteins (NAPs), which serve to protect and deliver BoNT through the gastrointestinal tract in food borne botulism. HA33 is a key NAP component tha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.03.008

    authors： Lee K,Lam KH,Kruel AM,Perry K,Rummel A,Jin R

    更新日期：2014-04-04 00:00:00

  • Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.

    abstract：:The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.10.130

    authors： Hong W,Li J,Wang B,Chen L,Niu W,Yao Z,Baniahmad A

    更新日期：2011-12-02 00:00:00

  • Of mice and men: from early NMR studies of the heart to physiological genomics.

    abstract：:Just before I became an editor of Biochemical and Biophysical Research Communications in 1977 we published our first paper in this same journal on the study of tiny perfused rat hearts by (31)P NMR. In this article I trace the development of this in vivo NMR approach from the study of small rat and mouse hearts to hum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1006/bbrc.1999.1890

    authors： Radda GK

    更新日期：1999-12-29 00:00:00

  • Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of nuclear receptors, is expressed at a high level in adipose tissue and plays an important role in adipocyte differentiation. In the present study, we identified the expression of PPARgamma in rat aortic smooth muscle cells (RASMC) using reverse t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8794

    authors： Iijima K,Yoshizumi M,Ako J,Eto M,Kim S,Hashimoto M,Sugimoto N,Liang YQ,Sudoh N,Toba K,Ouchi Y

    更新日期：1998-06-18 00:00:00

  • Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells.

    abstract：:A major problem in the treatment of type 1 diabetes mellitus is the limited availability of alternative sources of insulin-producing cells for islet transplantation. In this study, we investigated the effect of bone morphogenetic protein 4 (BMP-4) treatments of gnotobiotic porcine skin-derived stem cells (gSDSCs) on t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.05.158

    authors： Yang JH,Lee SH,Heo YT,Uhm SJ,Lee HT

    更新日期：2010-07-09 00:00:00