当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes.

Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes.

Abstract：

:Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. Mast cells mature locally; thus, tissue-specific influences are important for promoting mast cell accumulation and survival in the skin and the gastrointestinal tract. In this study, we determined the effects of keratinocytes on mast cell accumulation during Th17-mediated skin inflammation. We observed increases in dermal mast cells in imiquimod-induced psoriatic dermatitis in mice accompanied by the expression of epidermal stem cell factor (SCF), a critical mast cell growth factor. Similar to mouse epidermal keratinocytes, SCF was highly expressed in the human HaCaT keratinocyte cell line following stimulation with IL-17. Further, keratinocytes promoted mast cell proliferation following stimulation with IL-17 in vitro. However, the effects of keratinocytes on mast cells were significantly diminished in the presence of anti-CD117 (stem cell factor receptor) blocking antibodies. Taken together, our results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cho KA,Park M,Kim YH,Woo SY

doi

10.1016/j.bbrc.2017.04.141

subject

Has Abstract

pub_date

2017-06-10 00:00:00

pages

856-861

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30823-9

journal_volume

487

pub_type

杂志文章

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