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CRIPTO3, a presumed pseudogene, is expressed in cancer.

Abstract：

:Cripto is a cell surface protein highly expressed in certain solid tumors, and overexpression of Cripto protein is oncogenic. Cripto-1 protein is encoded by CRIPTO1 gene. CRIPTO3, a presumed pseudogene, has an open reading frame with six amino acid differences from Cripto-1. We show that CRIPTO3 mRNA is the CRIPTO message expressed in many cancer samples. A CRIPTO3 SAGE tag was found in several cancer SAGE libraries, while the CRIPTO1 tag was found in ES cell libraries. In vitro experiments indicate both Cripto-1 and Cripto-3 proteins are functional in the Nodal-dependent signal pathway. Our data indicate that CRIPTO3 is an expressed gene, particularly in certain cancers, and suggest a potentially novel mechanism of oncogenesis through activation of a retrogene.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sun C,Orozco O,Olson DL,Choi E,Garber E,Tizard R,Szak S,Sanicola M,Carulli JP

doi

10.1016/j.bbrc.2008.09.113

subject

Has Abstract

pub_date

2008-12-05 00:00:00

pages

215-20

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01881-0

journal_volume

377

pub_type

杂志文章

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