Nucleoside transport in activated macrophages.

Abstract:

:The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-gamma, a stimulus able to activate macrophage and to induce the production of tumor necrosis factor-alpha, within few hours markedly increased [3H]-uridine uptake by mouse macrophage. Other stimuli devoid of activation capacity, such as inert phagocytable latex beads, did not affect this phenomenon, which appeared to be related to macrophage activation. The increase in [3H]-uridine uptake may be an useful phenomenon in studying the early biochemical events associated with macrophage activation.

authors

Busolo F,Conventi L,Gatti C,Monti D,Troiano L,Franceschi C

doi

10.1016/0006-291x(89)91663-x

subject

Has Abstract

pub_date

1989-04-14 00:00:00

pages

354-61

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91663-X

journal_volume

160

pub_type

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