Abstract:
:The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-gamma, a stimulus able to activate macrophage and to induce the production of tumor necrosis factor-alpha, within few hours markedly increased [3H]-uridine uptake by mouse macrophage. Other stimuli devoid of activation capacity, such as inert phagocytable latex beads, did not affect this phenomenon, which appeared to be related to macrophage activation. The increase in [3H]-uridine uptake may be an useful phenomenon in studying the early biochemical events associated with macrophage activation.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Busolo F,Conventi L,Gatti C,Monti D,Troiano L,Franceschi Cdoi
10.1016/0006-291x(89)91663-xsubject
Has Abstractpub_date
1989-04-14 00:00:00pages
354-61issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(89)91663-Xjournal_volume
160pub_type
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journal_title:Biochemical and biophysical research communications
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更新日期:1995-03-17 00:00:00
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更新日期:1999-09-24 00:00:00