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Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling.

Abstract：

:Intracellular Ca2+ plays an important role in a variety of second messenger cascades. The function of Ca2+ is mediated, in part, by Ca2+-binding proteins such as calmodulin, calretinin, calbindin, neurocalcin, recoverin, and visinin-like proteins (VILIPs). These proteins are highly expressed in rat olfactory receptor neurons (ORNs) and are localized to distinct intracellular regions. In the present study, we have identified another Ca2+-binding protein, hippocalcin, in the rat olfactory epithelium (OE). Olfactory/brain hippocalcin shows high sequence homology with hippocalcins expressed in mice and humans. Hippocalcin was predominantly localized to the olfactory cilia, the site of the initial events of olfactory signal transduction, and was found to regulate the activity of ciliary adenylate cyclases (ACs) and particulate guanylyl cyclases (GCs) in a Ca2+-dependent manner. These data indicate that hippocalcin is expressed in rat ORNs, and is likely to regulate second messenger cascades in a Ca2+-dependent manner.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mammen A,Simpson PJ,Nighorn A,Imanishi Y,Palczewski K,Ronnett GV,Moon C

doi

10.1016/j.bbrc.2004.07.123

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1131-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01603-1

journal_volume

322

pub_type

杂志文章

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