Leucine-rich repeat-containing G-protein coupled receptor 5 enriched organoids under chemically-defined growth conditions.

abstract：:The transmissible spongiform encephalopathies comprise a group of fatal neurodegenerative diseases that are characterized by the conversion of the normal host cellular prion protein (PrPC) to the abnormal protease-resistant isoform PrPSC. Distinct alterations of transcriptional regulation during disease progression co...

journal_title：Biochemical and biophysical research communications

authors： Schröder B,Groschup M,Hunsmann G,Bodemer W

更新日期：1998-10-20 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

journal_title：Biochemical and biophysical research communications

authors： Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

更新日期：2004-12-17 00:00:00

abstract：:Microfilaments play an important role in the formation of apoptotic bodies. This study examined expression patterns of beta-actin, a key component of microfilament, during apoptosis. The data suggest that continuous beta-actin expression is not required for formation of apoptotic bodies. beta-actin mRNA levels rapidly...

journal_title：Biochemical and biophysical research communications

authors： Naora H,Naora H

更新日期：1995-06-15 00:00:00

abstract：:We have previously reported the identification of two closely related RNA binding proteins from Trypanosoma brucei which we have termed p34 and p37. The predicted primary structures of the two proteins are highly homologous with one major difference, an 18-amino-acid insert in the N-terminal region of p37. These two p...

journal_title：Biochemical and biophysical research communications

authors： Pitula J,Ruyechan WT,Williams N

更新日期：2002-01-11 00:00:00

abstract：:The presence of cancer stem cells, in both hematopoietic and solid malignancies, has been recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like properties of sphere-colony forming cells in rat osteosarcoma and malignant fibrous histiocytoma cell lines. The results showed that bo...

journal_title：Biochemical and biophysical research communications

authors： Fujii H,Honoki K,Tsujiuchi T,Kido A,Yoshitani K,Mori T,Takakura Y

更新日期：2007-10-26 00:00:00

abstract：:The cellular response to DNA damage induced by gamma-irradiation activates cell-cycle arrest to permit DNA repair and to prevent replication. Cyclin D1 is the key molecule for transition between the G1 and S phases of the cell-cycle, and amplification or overexpression of cyclin D1 plays pivotal roles in the developme...

journal_title：Biochemical and biophysical research communications

authors： Choo DW,Baek HJ,Motoyama N,Cho KH,Kim HS,Kim SS

更新日期：2009-01-23 00:00:00

abstract：:The effects of dopamine (DA) on 45Ca2+ ion movement and prolactin release in dispersed female rat anterior pituitary cells were studied to elucidate the mechanism for DA reduction of intracellular calcium levels. In 45Ca2+ prelabeled cells, DA inhibited fractional calcium efflux and prolactin release simultaneously an...

journal_title：Biochemical and biophysical research communications

authors： Login IS,Judd AM,MacLeod RM

更新日期：1988-03-15 00:00:00

abstract：:At 10 microM, 1-0-oleoyl-, 1-0-palmitoyl-, and 1-0-myristoyl-2-0-acetyl-glycerol weakly stimulated neutrophils to release lysozyme, an enzyme in secondary granules, but had no such effect on the release of a primary granule enzyme, beta-glucuronidase. The glycerides (1-10 microM) had a second effect on both granule po...

journal_title：Biochemical and biophysical research communications

authors： O'Flaherty JT,Schmitt JD,McCall CE,Wykle RL

更新日期：1984-08-30 00:00:00

abstract：:Here we describe the molecular cloning of human cyclin B3, its localization, and its structure. It is localized in the subcentromeric region of the X chromosome, still not completely sequenced by the Human Genome Project. This cyclin B3 is unusually large for a mitotic cyclin. Its mRNAs were found in all tissues and w...

journal_title：Biochemical and biophysical research communications

authors： Lozano JC,Perret E,Schatt P,Arnould C,Peaucellier G,Picard A

更新日期：2002-02-22 00:00:00

abstract：:We report the cloning and characterization of both the cDNA (tufA) and genomic clones encoding for a chloroplast translation elongation factor (EF-Tu) from pea. The analysis of the deduced amino acids of the cDNA clone reveals the presence of putative transit peptide sequence and four GTP binding domains and two EF-Tu...

journal_title：Biochemical and biophysical research communications

authors： Singh BN,Mishra RN,Agarwal PK,Goswami M,Nair S,Sopory SK,Reddy MK

更新日期：2004-07-23 00:00:00

abstract：:Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported ...

journal_title：Biochemical and biophysical research communications

authors： Peng S,Miao C,Li J,Fan X,Cao Y,Duan E

更新日期：2006-11-24 00:00:00

abstract：:Manganese-dependent superoxide dismutase (MnSOD) is localized in the mitochondria and is important for oxidative stress resistance. Although transcriptional regulation of MnSOD has been relatively well studied, much less is known about the protein's posttranslational regulation. In budding yeast, MnSOD is activated af...

journal_title：Biochemical and biophysical research communications

authors： Takahashi H,Suzuki T,Shirai A,Matsuyama A,Dohmae N,Yoshida M

更新日期：2011-03-04 00:00:00

abstract：:N-terminal of Leu-norleucinal or Leu-methioninal was modified to obtain a cell penetrative peptide inhibitor against calpain. Benzyloxycarbonyl (Z) derivatives had less active against papain than phenylbutyryl derivatives and leupeptin. Z-Leu-nLeu-H (calpeptin) was more sensitive to calpain I than Z-Leu-Met-H and leup...

journal_title：Biochemical and biophysical research communications

authors： Tsujinaka T,Kajiwara Y,Kambayashi J,Sakon M,Higuchi N,Tanaka T,Mori T

更新日期：1988-06-30 00:00:00

abstract：:Low density lipoprotein (LDL) is readily oxidized under certain conditions, resulting in the formation of oxidized LDL (oxLDL). Despite numerous in vitro reports that reveal the pathogenic role of oxidative stress, anti-oxidative strategies have underperformed in the clinic. In this study, we examine the role of oxLDL...

journal_title：Biochemical and biophysical research communications

authors： Kim OS,Lee CS,Joe EH,Jou I

更新日期：2006-03-31 00:00:00

abstract：:Cyclooxygenase 2 (COX)-2 is induced by bacterial and viral infections and has complex, poorly understood roles in anti-pathogen immunity. Here, we use a knock-in luciferase reporter model to image Cox2 expression across a range of tissues in mice following treatment with the either the prototypical bacterial pathogen-...

journal_title：Biochemical and biophysical research communications

authors： Kirkby NS,Zaiss AK,Wright WR,Jiao J,Chan MV,Warner TD,Herschman HR,Mitchell JA

更新日期：2013-08-23 00:00:00

abstract：:Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of...

journal_title：Biochemical and biophysical research communications

authors： Rossi L,Ciriolo MR,Marchese E,De Martino A,Giorgi M,Rotilio G

更新日期：1994-09-15 00:00:00

abstract：:We have cloned the 5' upstream -1034 to +88 fragment of the human inducible nitric oxide synthase (hiNOS) gene and demonstrate its competence to promote luciferase gene transcription in vascular-smooth-muscle (VSM) cells and macrophages. Sequential 5' end-deletions localized positive regulatory elements of hiNOS trans...

journal_title：Biochemical and biophysical research communications

authors： Kolyada AY,Savikovsky N,Madias NE

更新日期：1996-03-27 00:00:00

abstract：:MicroRNAs are involved in cancer-related processes. The microRNA-21(miR-21) has been identified as the only miRNA over-expressed in a wide variety of cancers, including cervical cancer. However, the function of miR-21 is unknown in cervical carcinomas. In this study, we found that the inhibition of miR-21 in HeLa cerv...

journal_title：Biochemical and biophysical research communications

authors： Yao Q,Xu H,Zhang QQ,Zhou H,Qu LH

更新日期：2009-10-23 00:00:00

abstract：:Estrogen depletion causes postmenopausal osteoporosis. Here we report that steady state mRNA levels of transforming growth factor-beta 1 (TGF-beta 1) and osteocalcin in bone persistently decreased and increased, respectively, in vivo in estrogen-depleted rats after ovariectomy (OVX). 21 female Wistar rats (7-month-old...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Shigeno C,Kasai R,Kohno H,Ohta S,Okumura H,Konishi J,Yamamuro T

更新日期：1993-08-16 00:00:00

abstract：:Mitochondrial dysfunction manifests in the pathogenesis of Huntington's disease (HD), a fatal and inherited neurodegenerative disease. Dynamin-related protein 1 (Drp1) is the primary component of mitochondrial fission and becomes hyperactivated in various models of HD. We previously reported that inhibition of Drp1 hy...

journal_title：Biochemical and biophysical research communications

authors： Zhao Y,Sun X,Qi X

更新日期：2018-12-09 00:00:00

abstract：:Tissue transglutaminase (tTgase) contributes to the organisation of the basement membrane and is therefore thought to be important for the integrity and stability of the vessel wall. In the present study, we hypothesised that the HMG-CoA reductase inhibitor atorvastatin may up-regulate the tTgase expression in endothe...

journal_title：Biochemical and biophysical research communications

authors： Soehnlein O,Eskafi S,Schmeisser A,Kloos H,Daniel WG,Garlichs CD

更新日期：2004-09-10 00:00:00

abstract：:Human untranslated region (UTR) databases were searched to identify novel proteins potentially regulated by an iron responsive element (IRE), and found two candidates-cell cycle phosphatase Cdc14A variant 1 and myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha), both possessing a putative IRE in ...

journal_title：Biochemical and biophysical research communications

authors： Cmejla R,Petrak J,Cmejlova J

更新日期：2006-03-03 00:00:00

abstract：:We have isolated and characterized the 5'-flanking region of the mouse RECK gene aiming to understand the mechanism of oncogene-mediated suppression of RECK gene expression. The upstream 52-base region was found to contain a promoter activity which is, to some extent, suppressed by the ras oncogene. This region contai...

journal_title：Biochemical and biophysical research communications

authors： Sasahara RM,Takahashi C,Noda M

更新日期：1999-11-02 00:00:00

abstract：:Rab proteins, members of the Ras superfamily of small GTPases, play regulatory roles in intercompartmental vesicular transport. Each step of traffic seems to require the participation of at least one distinct Rab, with the Rab3 subfamily involved in stimulated exocytosis. We report our studies on the murine rab3D gene...

journal_title：Biochemical and biophysical research communications

authors： Adachi R,Nigam R,Tuvim MJ,DeMayo F,Dickey BF

更新日期：2000-07-14 00:00:00

abstract：:We present here further evidence supporting that histone H1 contains a nucleotide binding site interacting e.g. with ADP, ATP, GDP and GTP. The finding is in accordance with the previous observation that nucleotides modulate recognition of DNA by H1. Most interestingly, H1 appears to be capable of hydrolyzing NTPs and...

journal_title：Biochemical and biophysical research communications

authors： Mannermaa RM,Oikarinen J

更新日期：1992-01-15 00:00:00

abstract：:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necr...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Murakami M,Maeda H,Hibi M,Uede T

更新日期：1997-04-07 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been demonstrated to be intensively involved in the development of various carcinomas, including glioblastoma multiforme (GBM). However, only a few of them have been well characterized. LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tis...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Dai W,Wang H,Pan H,Wang Q

更新日期：2018-06-12 00:00:00

abstract：:A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clon...

journal_title：Biochemical and biophysical research communications

authors： Tsuzuki T,Nomiyama H,Setoyama C,Maeda S,Shimada K,Pestka S

更新日期：1983-07-29 00:00:00

abstract：:Macrophage colony stimulating factor (CSF-1) is a member of a family of glycoproteins that are necessary for the normal proliferation and differentiation of myeloid progenitor cells. The human CSF-1 gene has previously been assigned to chromosome 5 using somatic cell hybrids, and further localized to 5q33 by in situ h...

journal_title：Biochemical and biophysical research communications

authors： Saltman DL,Dolganov GM,Hinton LM,Lovett M

更新日期：1992-02-14 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the...

journal_title：Biochemical and biophysical research communications

authors： Kim HG,Han EH,Im JH,Lee EJ,Jin SW,Jeong HG

更新日期：2015-09-25 00:00:00