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Transport of newly synthesized arylsulfatase A to the lysosome via transferrin receptor-positive compartments.

Abstract：

:We have studied the convergence of the biosynthetic lysosomal route marked by the newly synthesized lysosomal enzyme arylsulfatase A (ASA) with the endosomal/prelysosomal compartment in ASA overexpressing baby hamster kidney (BHK) cells. A monoclonal antibody against ASA conjugated to transferrin (Tf-alpha ASA) was used to load the endocytic pathway via the transferrin receptor. Subsequent internalization of [125I]labeled ASA and Tf-alpha ASA conjugates at 18 degrees C followed by rewarming to 37 degrees C showed that immunocomplexes were formed within the recycling pathway and released into the medium. Furthermore, in cells labeled with [35S]methionine for 10 min about 54% of newly synthesized ASA passed into Tf-alpha ASA accessible compartments during a 4 hour chase period and accumulated in the medium. These data indicate that in overexpressing BHK cells the majority of newly synthesized ASA is transported to the lysosome via transferrin receptor-containing early endosomes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Diesner F,Sommerlade HJ,Braulke T

doi

10.1006/bbrc.1993.2432

subject

Has Abstract

pub_date

1993-11-30 00:00:00

pages

1-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72432-0

journal_volume

197

pub_type

杂志文章

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