Abstract:
:We examined the adrenocorticotropic hormone-releasing activities of several human interleukin-1 beta analogues that have markedly reduced pyrogenic activities in rats. Among the analogues tested, [Gly4]-, [Leu93]- and [1-148]-interleukin-1 beta increased the plasma adrenocorticotropic hormone level to almost that induced by authentic human interleukin-1 beta. Modifications of the N-terminus of the authentic molecule, i.e., [7-153]- and [Des-Ala1, Asp4]-interleukin-1 beta, significantly reduced the hormone-releasing activity. These data suggest that the adrenocorticotropic hormone-releasing activity of human interleukin-1 beta resides in the N-terminal structure of the authentic peptide and can be separated from its pyrogenic activity.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Naito Y,Fukata J,Masui Y,Hirai Y,Murakami N,Tominaga T,Nakai Y,Tamai S,Mori K,Imura Hdoi
10.1016/0006-291x(90)91736-csubject
Has Abstractpub_date
1990-02-28 00:00:00pages
103-9issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(90)91736-Cjournal_volume
167pub_type
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