Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production.


:Thiol and disulfide compounds were tested as an anti-HIV drug against transactivator (Tat)-mediated transactivation of HIV-1. Of all the compounds tested, thiamine disulfide, alpha-lipoic acid, and N-acetycysteine significantly depressed HIV-1 Tat activity. Thiamine disulfide alone in these compounds possessing anti-HIV-Tat activity markedly inhibited production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 microM. Thiamine disulfide (500 microM) blocked 99.7% of HIV-1 production after 96 hr culture in acute HIV-1 (LAV-1) infection (m.o.i. = 0.002), whereas it inhibited 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB). The results suggest that thiamine disulfide may be important for AIDS chemotherapy.


Shoji S,Furuishi K,Misumi S,Miyazaki T,Kino M,Yamataka K




Has Abstract


1994-11-30 00:00:00














  • Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.

    abstract::Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway inhibitor (TFPI) in human monocyte-derived macrophages (MDMs) was induced by choles...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Espada S,Stavik B,Holm S,Sagen EL,Bjerkeli V,Skjelland M,Dahl TB,Espevik T,Kanse S,Sandset PM,Skretting G,Halvorsen B

    更新日期:2017-09-16 00:00:00

  • Induction of TAp63 by histone deacetylase inhibitors.

    abstract::TAp63 belongs to the p53-tumour suppressor family and is capable of transactivating a set of target genes to induce cell cycle arrest and apoptosis. We showed that treatment of cancer cells with chemo-therapeutic drugs or the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) results in induction of TAp63 expre...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sayan BS,Yang AL,Conforti F,Bernardini S,Tucci P,Vasa-Nicotera M,Knight RA,Melino G

    更新日期:2010-01-22 00:00:00

  • Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice.

    abstract::Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism of allergic asthma-aggravated atherosclerosis-induced c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gao S,Wang C,Li W,Shu S,Zhou J,Yuan Z,Wang L

    更新日期:2019-11-19 00:00:00

  • Effect of concentration on the cytotoxic mechanism of doxorubicin--apoptosis and oxidative DNA damage.

    abstract::Anthracycline derivatives such as doxorubicin are part of many chemotherapeutic regimens and reach peak plasma concentrations of 5 microM. We investigated the cytotoxic mechanisms of various doxorubicin concentrations in MOLT-4 ALL-cells. Concentrations of up to 100 microM doxorubicin achieved similar cytotoxic effect...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Müller I,Jenner A,Bruchelt G,Niethammer D,Halliwell B

    更新日期:1997-01-13 00:00:00

  • The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.

    abstract::Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explai...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lee SH,Choi JM,Jung SY,Cox AR,Hartig SM,Moore DD,Kim KH

    更新日期:2021-01-01 00:00:00

  • Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.

    abstract::The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum acti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fujiki H,Tanaka Y,Miyake R,Kikkawa U,Nishizuka Y,Sugimura T

    更新日期:1984-04-30 00:00:00

  • Active sites of two orthologous cytochromes P450 2E1: differences revealed by spectroscopic methods.

    abstract::Cytochromes P450 2E1 of human and minipig origin were examined by absorption spectroscopy under high hydrostatic pressure and by resonance Raman spectroscopy. Human enzyme tends to denature to the P420 form more easily than the minipig form; moreover, the apparent compressibility of the heme active site (as judged fro...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Anzenbacherova E,Hudecek J,Murgida D,Hildebrandt P,Marchal S,Lange R,Anzenbacher P

    更新日期:2005-12-09 00:00:00

  • Cloning and immunolocalization of a rat pancreatic Na(+) bicarbonate cotransporter.

    abstract::In the rat, pancreatic HCO(-)(3) secretion is believed to be mediated by duct cells with an apical Cl(-)/HCO(-)(3) exchanger acting in parallel with a cAMP-activated Cl(-) channel and protons being extruded through a basolateral Na(+)/H(+) exchanger. However, this may not be the only mechanism for HCO(-)(3) secretion ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Thévenod F,Roussa E,Schmitt BM,Romero MF

    更新日期:1999-10-14 00:00:00

  • Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.

    abstract::Glycogen synthase kinase-3beta (GSK3beta) is recognized as one of major kinases to phosphorylate tau in Alzheimer's disease (AD), thus lots of AD drug discoveries target GSK3beta. However, the inactive form of GSK3beta which is phosphorylated at serine-9 is increased in AD brains. This is also inconsistent with phosph...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lim YW,Yoon SY,Choi JE,Kim SM,Lee HS,Choe H,Lee SC,Kim DH

    更新日期:2010-04-30 00:00:00

  • MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3.

    abstract::MicroRNAs are aberrantly expressed in a wide variety of human cancers. The present study aims to elucidate the effects and molecular mechanisms of miR-144-3p that underlie gastric cancer (GC) development. It was observed that miR-144-3p expression was significantly decreased in GC tissues compared to that in paired no...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li B,Zhang S,Shen H,Li C

    更新日期:2017-03-04 00:00:00

  • Cleavage of DNA by N-phosphoryl histidine.

    abstract::DNA cleavage by N-(O,O-diisopropyl)phosphoryl histidine(DIPP-His) is investigated by a submarine agarose electrophoresis technique. It was found that DIPP-His could cleave supercoiled DNAs and lambda DNA without the participation of divalent metal ions, while the histidine itself and N-(O,O-diisopropyl)phosphoryl alan...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Li Y,Sha YW,Ma Y,Zhao Y

    更新日期:1995-08-24 00:00:00

  • Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells.

    abstract::Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. In cultured bovine aortic endothelial cells (BAEC), we have found that a 130 kDa protein (p130) was rapidly tyrosine phosphorylated within ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ochi H,Kume N,Nishi E,Moriwaki H,Masuda M,Fujiwara K,Kita T

    更新日期:1998-02-24 00:00:00

  • N-Propionylmannosamine-induced over-expression and secretion of thioredoxin leads to neurite outgrowth of PC12 cells.

    abstract::The function of the central nervous system largely depends on growth and differentiation (neurite outgrowth) of neural cells and it is well established that growth factors, especially nerve growth factor NGF stimulate neurite outgrowth. However, additional factors are implicated in this process notably the redox state...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Horstkorte R,Reinke S,Bauer C,Reutter W,Kontou M

    更新日期:2010-05-07 00:00:00

  • Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb/C 3T3 cells.

    abstract::Treatment of quiescent Balb/c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cyc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Chiou ST,Chang WC

    更新日期:1992-03-16 00:00:00

  • Isoform-specific phosphorylation of fission yeast type 2C protein phosphatase.

    abstract::Protein phosphatase 2C (PP2C) is one of the four major protein serine/threonine phosphatases of eukaryotes and is implicated in the regulation of various cellular functions. With the goal of elucidating the mechanism responsible for regulating PP2C functions, we investigated the significance of phosphorylation of fiss...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kobayashi T,Sadaie M,Ohnishi M,Wang H,Ikeda S,Hanada M,Yanagawa Y,Nakajima T,Tamura S

    更新日期:1998-10-09 00:00:00

  • NF-Y and Sp1 are involved in transcriptional regulation of rat SND p102 gene.

    abstract::SND p102 is a rat liver endoplasmic reticulum cholesterol ester hydrolase recently described as a member of a conserved family of transcriptional coactivators that promotes phospholipid secretion into lipoproteins when overexpressed in hepatocytes. In this work, we report first evidence for a mechanism of transcriptio...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rodríguez L,Ochoa B,Martínez MJ

    更新日期:2007-04-27 00:00:00

  • NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation.

    abstract::The sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rosini P,De Chiara G,Lucibello M,Garaci E,Cozzolino F,Torcia M

    更新日期:2000-11-30 00:00:00

  • Multi-frequency EPR evidence for a binuclear CuA center in cytochrome c oxidase: studies with a 63Cu- and 65Cu-enriched, soluble domain of the cytochrome ba3 subunit II from Thermus thermophilus.

    abstract::We have recorded multi-frequency EPR spectra of 63Cu- and 65Cu-labeled, water-soluble CuA-protein from the cytochrome ba3 of T. thermophilus. The spectrum taken at the highest frequency (34.03 GHz) shows no hyperfine structure and is nominally axial with apparent gz approximately 2.18 and gxy approximately 2.00. The s...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fee JA,Sanders D,Slutter CE,Doan PE,Aasa R,Karpefors M,Vänngård T

    更新日期:1995-07-06 00:00:00

  • Leucine zipper domain of HIV-1 gp41 interacted specifically with alpha-catenin.

    abstract::Interactions between viral and cellular proteins could explain the molecular mechanisms behind the viral life cycle of HIV-1. The envelope protein gp41 of HIV-1 specifically interacted with alpha-catenin, not with beta-catenin. This interaction was shown by in vitro protein assay and in vivo transfected cell systems. ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kim JT,Kim EM,Lee KH,Choi JE,Jhun BH,Kim JW

    更新日期:2002-03-15 00:00:00

  • Cloning and characterization of the 5'-flanking region of the Ehox gene.

    abstract::The paired-like homeobox-containing gene Ehox plays a role in embryonic stem cell differentiation and is highly expressed in the developing placenta and thymus. To understand the mechanisms of regulation of Ehox gene expression, the 5'-flanking region of the Ehox gene was isolated from a mouse BAC library. 5'-RACE ana...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lee WK,Kim YM,Malik N,Ma C,Westphal H

    更新日期:2006-03-03 00:00:00

  • The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity.

    abstract::The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identica...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gullberg U,Widegren B,Arnason U,Egesten A,Olsson I

    更新日期:1986-09-30 00:00:00

  • Role of N-terminal domain of streptokinase in protein transport.

    abstract::Streptokinase (SK), an extracellular protein of several haemolytic strains of Streptococcus, is utilized as a potent thrombolytic agent for the treatment of various myocardial disorders. Functional properties of SK remain unchanged when the first 13 N-terminal amino acid (aa) residues are removed. At present, role of ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Pratap J,Kaur J,RajaMohan G,Singh D,Dikshit KL

    更新日期:1996-10-03 00:00:00

  • Targeted connexin26 ablation arrests postnatal development of the organ of Corti.

    abstract::Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness. To investigate deafness mechanisms underlying Cx26 null mutations, we generated three independent lines of conditional Cx26 null mice. Cell differentiation and gross cochlear morphology at birth seeme...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang Y,Chang Q,Tang W,Sun Y,Zhou B,Li H,Lin X

    更新日期:2009-07-17 00:00:00

  • Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity.

    abstract::This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

    更新日期:2015-08-28 00:00:00

  • Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model.

    abstract::Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies h...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kaylani SZ,Xu J,Srivastava RK,Kopelovich L,Pressey JG,Athar M

    更新日期:2013-06-14 00:00:00

  • Different proliferative responses of periportal and perivenous hepatocytes to EGF.

    abstract::Stimulation of DNA synthesis by EGF was compared in cultured periportal and perivenous hepatocyte populations. Periportal hepatocytes responded to EGF more sensitive (IC50-values 20 vs 75 ng/ml) and with a higher maximal stimulation (420 vs 290%) than perivenous hepatocytes with respect to both [3H]thymidine incorpora...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gebhardt R,Jonitza D

    更新日期:1991-12-31 00:00:00

  • Protein-lipid interactions and enzyme requirements for light subtype generation on cycling reconstituted surfactant.

    abstract::Surfactant convertase is required for conversion of heavy density (H) natural surfactant to light density (L) subtype during cycling in vitro, a technique that reproduces surfactant metabolism. To study mechanisms of H to L conversion, we prepared liposomes of dipalmitoylphosphatidylcholine (DPPC) and phosphatidylglyc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Dhand R,Sharma VK,Teng AL,Krishnasamy S,Gross NJ

    更新日期:1998-03-27 00:00:00

  • Deuterium distribution in lactate as tracer of metabolic pathways.

    abstract::2H-NMR spectroscopy has been used to study the distribution of 2H atoms in brain lactate, after intraperitoneal injection of 2H2O. Information on brain metabolism was obtained from the ratio [(3-2H) lactate]/[(2-2H)-lactate] which was found very sensitive to the PO2 in the breathing air. The dependence of this ratio o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vianello F,Scarpa M,Viglino P,Rigo A

    更新日期:1997-08-28 00:00:00

  • Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.

    abstract::Previously, we reported that metabolism of arachidonic acid through the 5-lipoxygenase (5-LOX) pathway plays an important role in the survival and growth of human prostate cancer cells. Inhibition of 5-LOX by pharmacological inhibitors triggers apoptosis in prostate cancer cells within hours of treatment, which is pre...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sundaram S,Ghosh J

    更新日期:2006-01-06 00:00:00

  • Isolation and primary structure of a neuropeptide hormone from Heliothis zea with hypertrehalosemic and adipokinetic activities.

    abstract::A neuropeptide was isolated from the corpora cardiaca of the corn earworm moth Heliothis zea, and purified by sequential gradient elution in three reversed phase-high performance liquid chromatographic steps. The primary structure, pGlu-Leu-Thr-Phe-Ser-Ser-Gly-Trp-Gly-Asn-NH2 was determined by automated gas-phase Edma...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jaffe H,Raina AK,Riley CT,Fraser BA,Bird TG,Tseng CM,Zhang YS,Hayes DK

    更新日期:1988-08-30 00:00:00