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Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patients.

Abstract：

:The amount of oxidative stress in severely traumatized patients is usually based on various individual parameters such as total antioxidants and lipid peroxidation. Serial measurements of plasma oxidation-reduction potential (ORP) in severely traumatized patients as a simple mean of assessing overall oxidative stress is described. Serial whole blood samples were obtained from multi-trauma patients (N=39) and healthy individuals (N=10). Plasma ORP in multi-trauma patients increased during the first few days of hospitalization and approached normal ORP levels upon discharge. On the ORP maxima day (5.8 days+/-0.5 SEM), a statistically significant decrease (p<0.05) was observed for negative acute phase reactants such as plasma paraoxonase-arylesterase (PON-AE) activity and total plasma protein in comparison with admission plasma levels. Monitoring ORP could be a useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rael LT,Bar-Or R,Aumann RM,Slone DS,Mains CW,Bar-Or D

doi

10.1016/j.bbrc.2007.07.078

subject

Has Abstract

pub_date

2007-09-21 00:00:00

pages

561-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01551-3

journal_volume

361

pub_type

杂志文章

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