Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis.


:Synovial chondromatosis is characterized by the formation of osteocartilaginous nodules (free bodies) under the surface of the synovial membrane in joints. Free bodies and synovium isolated from synovial chondromatosis patients expressed high levels of BMP-2 and BMP-4 mRNAs. BMP-2 stimulated the expression of Sox9, Col2a1, and Aggrecan mRNAs in free-body and synovial cells and that of Runx2, Col1a1, and Osteocalcin mRNAs in the synovial [corrected] cells only. BMP-2 increased the number of alcian blue-positive colonies in the free-body cell culture but not in the synovial cell culture. Noggin suppressed the expression of Sox9, Col2a1, Aggrecan, and Runx2 mRNAs in both the free-body and synovial cells. Further, it inhibited Osteocalcin expression in the synovial cells. These results suggest that BMPs are involved in the pathobiology of cartilaginous and osteogenic metaplasia observed in synovial chondromatosis.


Nakanishi S,Sakamoto K,Yoshitake H,Kino K,Amagasa T,Yamaguchi A




Has Abstract


2009-02-20 00:00:00














  • Crystal structure of GTPase-activating domain from human MgcRacGAP.

    abstract::Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). Rho GTPases act as molecular switches to regulate the actin cytoskeleton for cytokinesis, of which Rac1 is regulated by MgcRacGAP. In this study, we determined the...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Matsuura A,Lee HH

    更新日期:2013-06-07 00:00:00

  • GroEL-like protein complex of thermophilic bacterium Thermus aquaticus.

    abstract::GroEL-like particles of Thermus aquaticus are homo-oligomeric complexes of two stacked seven member rings, sedimenting in the gradient at 20S. The apparent molecular mass of the native particles is 820,000 (+/- 30,000). The protein complex is composed with one polypeptide of M(r) 59,000. Immunoblotting results and N-t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mikulík K,Benada O

    更新日期:1993-12-15 00:00:00

  • Identification, characterization and structure analysis of a type I ribosome-inactivating protein from Sapium sebiferum (Euphorbiaceae).

    abstract::Ribosome-inactivating proteins (RIPs) are N-glycosidases (EC3.2.2.22) that universally inactivate the ribosome, thereby inhibiting protein biosynthesis. In this study, a novel type I RIPs named SEBIN was identified in Sapium sebiferum. Nuclear acid depurine experiment showed that SEBIN had rRNA N-Glycosidase activity....

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wu Y,Mao Y,Jin S,Hou J,Du H,Yang M,Wu L

    更新日期:2015-08-07 00:00:00

  • Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.

    abstract::RegIIIβ and RegIIIγ are antimicrobial peptides expressed in intestinal epithelial cells. Expression of these peptides is reportedly decreased by high-fat diet (HFD) and increased by indigestible oligosaccharides in mice. Clearly, these dietary regimens change the structure of intestinal microbiota. We employed an inte...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Udomsopagit T,Miwa A,Seki M,Shimbori E,Kadota Y,Tochio T,Sonoyama K

    更新日期:2020-08-13 00:00:00

  • Aβ1-40 mediated aggregation of proteins and metabolites unveils the relevance of amyloid cross-seeding in amyloidogenesis.

    abstract::The multicomponent nature of neuronal plaques in Alzheimer's disease signifies the possible recruitment of non-Aβ candidates during the amyloid growth of Aβ peptides. Here, we show that amyloid fibrils of Aβ1-40 peptide can effectively initiate amyloid formation in different globular proteins and metabolites, converti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Anand BG,Prajapati KP,Kar K

    更新日期:2018-06-18 00:00:00

  • Expression of tenascin in the developing human small intestine.

    abstract::The expression of tenascin (Tn), an extracellular matrix glycoprotein, was analyzed in the human small intestine. Three major oligomeric forms of intestinal Tn (320 kDa, 220 kDa and 200 kDa) were identified in both the fetus and the adult. The intestinal 200 kDa form was not found expressed by intestinal mesenchymal c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Beaulieu JF,Jutras S,Kusakabe M,Perreault N

    更新日期:1993-05-14 00:00:00

  • Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells.

    abstract::Among the antimicrobial molecules produced by epithelial cells, DEFB4 is inducible in response to proinflammatory signals such as cytokines and bacterial molecules. Nontypeable Haemophilus influenzae (NTHi) is an important human pathogen that exacerbates chronic obstructive pulmonary disease in adult and causes otitis...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Woo JI,Kil SH,Pan H,Lee YJ,Lim DJ,Moon SK

    更新日期:2014-01-17 00:00:00

  • Characterization of the specific interaction between archaeal FHA domain-containing protein and the promoter of a flagellar-like gene-cluster and its regulation by phosphorylation.

    abstract::The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Duan X,He ZG

    更新日期:2011-04-01 00:00:00

  • Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apo-A-I.

    abstract::Lp-A-I was isolated by immunoaffinity chromatography and then separated into two fractions of large and small Lp-A-I particles by conventional ultracentrifugation with a cut-off density of 1.125 g/ml. The large and small particle-rich fractions were then radiolabeled with [125I]-Na and [131I]-Na, respectively. Both of...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Saku K,Liu R,Ohta T,Jimi S,Matsuda I,Arakawa K

    更新日期:1994-04-15 00:00:00

  • Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene.

    abstract::The efp, a member of the RING finger family, was previously identified as an estrogen responsive gene. Here, we characterized basal promoter of the human efp gene. Transcription initiation site was found at position -60 G relative to the site for translation initiation, and TATA motif was absent. Deletion and mutation...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ikeda K,Inoue S,Orimo A,Sano M,Watanabe T,Tsutsumi K,Muramatsu M

    更新日期:1997-07-30 00:00:00

  • Increased gene expression and production of murine endothelin receptors after birth.

    abstract::We developed the real-time PCR quantification of endothelin-A (ET-A) and endothelin-B (ET-B) receptor genes and present their relative expression levels in various adult tissues and during development in mouse using the 2(-Delta Delta C(T)) method. ET-A and ET-B receptors were detected in all tissues examined. Gene ex...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Adur J,Takizawa S,Quan J,Uchide T,Saida K

    更新日期:2003-06-06 00:00:00

  • Galanin increases cytoplasmic calcium in insulin-producing RINm5F cells by activating phospholipase C.

    abstract::We showed previously that the neuropeptide, galanin, transiently and promptly increases the cytoplasmic concentration of Ca2+, [Ca2+]i, in insulin producing clonal RINm5F cells prior to a reduction in [Ca2+]i. We found that galanin (100 nM) transiently increased the [Ca2+]i in the presence of 15 mM glyceraldehyde and ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ahrén B

    更新日期:1996-04-05 00:00:00

  • Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression.

    abstract::Activin belongs to transforming growth factor (TGF)-β super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew w...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Liu R,Wang JH,Xu C,Sun B,Kang SO

    更新日期:2016-10-28 00:00:00

  • Derivation of cranial neural crest-like cells from human embryonic stem cells.

    abstract::The neural crest is a transient population of multipotent progenitors contributing to a diverse array of tissues throughout the vertebrate embryo. Embryonic stem (ES) cells are able to form embryoid body and spontaneously differentiate to various lineages, following a reproducible temporal pattern of development that ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhou Y,Snead ML

    更新日期:2008-11-21 00:00:00

  • PREP1, MEIS1 homolog protein, regulates PF4 gene expression.

    abstract::We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cel...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

    更新日期:2003-05-23 00:00:00

  • Prediction of pi-turns in proteins using PSI-BLAST profiles and secondary structure information.

    abstract::Due to the structural and functional importance of tight turns, some methods have been proposed to predict gamma-turns, beta-turns, and alpha-turns in proteins. In the past, studies of pi-turns were made, but not a single prediction approach has been developed so far. It will be useful to develop a method for identify...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang Y,Xue ZD,Shi XH,Xu J

    更新日期:2006-09-01 00:00:00

  • Caspase-7 mediated cleavage of proteasome subunits during apoptosis.

    abstract::Caspase-3 and caspase-7 are structurally closely related and demonstrate overlapping substrate specificity. However, during apoptosis, they are differentially regulated and show distinct subcellular localizations, implying the presence of specific substrates. In this study, to identify caspase-7 substrates, we treated...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jang M,Park BC,Lee AY,Na KS,Kang S,Bae KH,Myung PK,Chung BC,Cho S,Lee DH,Park SG

    更新日期:2007-11-16 00:00:00

  • MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.

    abstract::Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological proc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhao XL,Li GZ,Sun B,Zhang ZL,Yin YH,Tian YS,Li H,Li HL,Wang de S,Zhong D

    更新日期:2010-02-19 00:00:00

  • The RB/E2F pathway and regulation of RNA processing.

    abstract::The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might p...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Ahlander J,Bosco G

    更新日期:2009-07-03 00:00:00

  • Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells.

    abstract::The Rho-associated coiled-coil kinase (ROCK) family of proteins, including ROCK1 and ROCK2, are key regulators of actin and intermediate filament morphology. The newly discovered ROCK substrate Tubulin polymerization promoting protein 1 (TPPP1) promotes microtubule polymerization and inhibits the activity of Histone d...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Schofield AV,Gamell C,Bernard O

    更新日期:2013-07-12 00:00:00

  • DNA-surfactant interactions: coupled cooperativity in ligand binding leads to duplex stabilization.

    abstract::The cooperative nature of interaction of cationic surfactants with short oligonucleotides leading to eventual stabilization of DNA duplexes is demonstrated. At submicellar concentrations and DNA:surfactant charge ratios of 0.2 to 0.8, the association of single chain (CTAB) and double chain (DOTAP) surfactants to oligo...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Pattarkine MV,Ganesh KN

    更新日期:1999-09-16 00:00:00

  • In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules.

    abstract::A small fraction of tumor cells are thought to possess the potential for both multiple-lineage differentiation and self-renewal, which underlies the cancer stem cell hypothesis. However, the differentiation mechanisms of these cells have not been elucidated due to a lack of appropriate culture methods. Here, we establ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kawamata M,Katsuda T,Yamada Y,Ochiya T

    更新日期:2017-01-22 00:00:00

  • An investigation on reduction process of cucumber ascorbate oxidase.

    abstract::Reduction process of cucumber ascorbate oxidase with L-ascorbate was investigated in detail through absorption and electron paramagnetic resonance (EPR) spectra under anaerobic condition. One of the three type I coppers (the type I copper which is oxidized rapidly (Sakurai, T. et al. (1985) Biochem. Biophys. Res. Comm...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sakurai T,Sawada S,Suzuki S,Nakahara A

    更新日期:1986-03-13 00:00:00

  • miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2.

    abstract::Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fu J,Xu X,Kang L,Zhou L,Wang S,Lu J,Cheng L,Fan Z,Yuan B,Tian P,Zheng X,Yu C,Ye Q,Lv Z

    更新日期:2014-03-07 00:00:00

  • Stable interdomain interaction within the cytoplasmic domain of CD45 increases enzyme stability.

    abstract::CD45 is a leukocyte-specific, two domain transmembrane tyrosine phosphatase. Co-purification of a recombinant protein containing the first phosphatase domain of CD45 (6His-D1) with a recombinant protein containing the second phosphatase domain (GST-D2) from E. coli indicated a stable interaction which resulted in incr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Felberg J,Johnson P

    更新日期:2000-05-10 00:00:00

  • Two genetically different MU-NANA neuraminidases in human leucocytes.

    abstract::Human leucocytes contain two different MU-NANA neuraminidases, which can be distinguished by Concanavalin A binding. The Con A binding form is predominant in lymphocytes (more than 80%) and the non-binding form predominates in granulocytes. The pH optima of both these neuraminidases as well as their subcellular locali...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Verheijen FW,Janse HC,van Diggelen OP,Bakker HD,Loonen MC,Durand P,Galjaard H

    更新日期:1983-12-16 00:00:00

  • Matrix vesicles and media vesicles as nonclassical pathways for the secretion of m-Calpain from MC3T3-E1 cells.

    abstract::Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

    更新日期:2001-07-20 00:00:00

  • The isoforms of α-actin and myosin affect the Ca2+ regulation of the actin-myosin interaction in the heart.

    abstract::Myocardium of mammals contains a wide range of isoforms of proteins that provides contractile function of the heart. These are two isoforms of ventricular and two of atrial myosin, α- and β-tropomyosin, and two isoforms of α-actin: cardiac and skeletal. We believe that the difference in the amino acid sequence of α-ac...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Shchepkin DV,Nikitina LV,Bershitsky SY,Kopylova GV

    更新日期:2017-08-19 00:00:00

  • Bioluminescent system for dynamic imaging of cell and animal behavior.

    abstract::The current utility of bioluminescence imaging is constrained by a low photon yield that limits temporal sensitivity. Here, we describe an imaging method that uses a chemiluminescent/fluorescent protein, ffLuc-cp156, which consists of a yellow variant of Aequorea GFP and firefly luciferase. We report an improvement in...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hara-Miyauchi C,Tsuji O,Hanyu A,Okada S,Yasuda A,Fukano T,Akazawa C,Nakamura M,Imamura T,Matsuzaki Y,Okano HJ,Miyawaki A,Okano H

    更新日期:2012-03-09 00:00:00

  • Characterisation of two novel CYP4 genes from the marine polychaete Nereis virens and their involvement in pyrene hydroxylase activity.

    abstract::Cytochrome P450 enzymes (CYP enzymes) catalyse the initial step in biotransformation of xenobiotics like polycyclic aromatic hydrocarbons (PAHs). The marine polychaete Nereis virens has a high capacity for biotransformation of PAHs. In the present study, the complete cDNA sequences of two novel CYP genes isolated from...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jørgensen A,Rasmussen LJ,Andersen O

    更新日期:2005-10-28 00:00:00