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Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis.

Abstract：

:Synovial chondromatosis is characterized by the formation of osteocartilaginous nodules (free bodies) under the surface of the synovial membrane in joints. Free bodies and synovium isolated from synovial chondromatosis patients expressed high levels of BMP-2 and BMP-4 mRNAs. BMP-2 stimulated the expression of Sox9, Col2a1, and Aggrecan mRNAs in free-body and synovial cells and that of Runx2, Col1a1, and Osteocalcin mRNAs in the synovial [corrected] cells only. BMP-2 increased the number of alcian blue-positive colonies in the free-body cell culture but not in the synovial cell culture. Noggin suppressed the expression of Sox9, Col2a1, Aggrecan, and Runx2 mRNAs in both the free-body and synovial cells. Further, it inhibited Osteocalcin expression in the synovial cells. These results suggest that BMPs are involved in the pathobiology of cartilaginous and osteogenic metaplasia observed in synovial chondromatosis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nakanishi S,Sakamoto K,Yoshitake H,Kino K,Amagasa T,Yamaguchi A

doi

10.1016/j.bbrc.2008.12.170

subject

Has Abstract

pub_date

2009-02-20 00:00:00

pages

914-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02573-4

journal_volume

379

pub_type

杂志文章

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