Stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in type 2 diabetes with nephropathy.

abstract：:By the use of well-characterized antibodies against porcine dynorphin-A(1-8), an endogenous opioid peptide, and the use of a modified immunofluorescence microscopic technique, dynorphin-A(1-8) stained perikarya, nerve fibres, and nerve terminals were visualized in the rat duodenum. Dynorphin-A(1-8) immunoreactive peri...

journal_title：Biochemical and biophysical research communications

authors： Wolter HJ

更新日期：1985-03-15 00:00:00

abstract：:Dlx5 transcription factor plays important roles in osteoblast differentiation and its transcription is regulated by many osteogenic signals including BMP-2. Recent studies suggest that the function of Dlx5 is also regulated post-translationally by protein kinases such as p38 and CaMKII. Protein kinase A (PKA) is invol...

journal_title：Biochemical and biophysical research communications

authors： Han Y,Jin YH,Yum J,Jeong HM,Choi JK,Yeo CY,Lee KY

更新日期：2011-04-15 00:00:00

abstract：:We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important...

journal_title：Biochemical and biophysical research communications

authors： Hirose K,Hakozaki M,Kakuchi J,Matsunaga K,Yoshikumi C,Takahashi M,Tochikura TS,Yamamoto N

更新日期：1987-12-16 00:00:00

abstract：:A170 is an oxidative stress-inducible protein having a Zinc finger domain, two PEST sequences, and many potential phosphorylation sites for serine/threonine kinases. These structural features suggest that the phosphorylation of A170 affects its function and degradation. We have found that A170 is phosphorylated in cul...

journal_title：Biochemical and biophysical research communications

authors： Yanagawa T,Yuki K,Yoshida H,Bannai S,Ishii T

更新日期：1997-12-08 00:00:00

abstract：:A high concentration of immunoreactive neuropeptide Y was observed in rat platelets using a specific and sensitive radioimmunoassay for neuropeptide Y. Three kinds of high performance liquid chromatography combined with radioimmunoassay for neuropeptide Y showed that immunoreactive neuropeptide Y in rat platelets is i...

journal_title：Biochemical and biophysical research communications

authors： Ogawa T,Kitamura K,Kawamoto M,Eto T,Tanaka K

更新日期：1989-12-29 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma, co-activator 1 alpha(PGC1α) effectively induced the biosynthesis of the mitochondria and the energy metabolism, and also regulated the muscle fiber-type shift. Overexpression of PGC1α gene in mice led to higher oxidative muscle fiber composition in muscle. However,...

journal_title：Biochemical and biophysical research communications

authors： Ying F,Zhang L,Bu G,Xiong Y,Zuo B

更新日期：2016-11-25 00:00:00

abstract：:The presence of a variety of cytokine-like molecules (IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha) in the hemocytes of two molluscs, i.e., Planorbarius corneus and Viviparus ater, is reported. These molecules are present only in hemocytes with phagocytic activity. These data, together with recent reports on the prese...

journal_title：Biochemical and biophysical research communications

authors： Ottaviani E,Franchini A,Franceschi C

更新日期：1993-09-15 00:00:00

abstract：:In the current study, we have examined the role of serotonin in regulating the levels of methyl farnesoate and ecdysteroids in the giant mud crab Scylla serrata and validated that serotonin indeed is a reproductive hormone. Administration of serotonin elevated circulatory levels of methyl farnesoate and ecdysteroids i...

journal_title：Biochemical and biophysical research communications

authors： Girish BP,Swetha CH,Reddy PS

更新日期：2017-09-02 00:00:00

abstract：:Synthesis of the vasodilator nitric oxide (NO) can be inhibited by the endogenous methylarginines L-NMMA and ADMA. ADMA is elevated in a number of cardiovascular disorders in which NO availability is reduced. Elimination of ADMA from the body occurs primarily by enzymatic breakdown through the action of DDAH, of which...

journal_title：Biochemical and biophysical research communications

authors： Jones LC,Tran CT,Leiper JM,Hingorani AD,Vallance P

更新日期：2003-10-24 00:00:00

abstract：:Biotin protein ligase (BPL) is an enzyme mediating biotinylation of a specific lysine residue of the carboxyl carrier protein (BCCP) of biotin-dependent enzymes. We recently found that the substrate specificity of BPL from archaeon Sulfolobus tokodaii is totally different from those of many other organisms, in reflect...

journal_title：Biochemical and biophysical research communications

authors： Sueda S,Li YQ,Kondo H,Kawarabayasi Y

更新日期：2006-05-26 00:00:00

abstract：:We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they possessed diverse suga...

journal_title：Biochemical and biophysical research communications

authors： Aono A,Hazama M,Notoya K,Taketomi S,Yamasaki H,Tsukuda R,Sasaki S,Fujisawa Y

更新日期：1995-05-25 00:00:00

abstract：:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necr...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Murakami M,Maeda H,Hibi M,Uede T

更新日期：1997-04-07 00:00:00

abstract：:We combined normal mode analysis (NMA) with cavity calculations as a method to get more insight into static crystal structures. We used nitrile hydratase (NHase) as a case study, and the crystal structure of a complex of Pseudonocardia thermophila NHase (1UGP) with n-butyric acid was chosen as a reference structure. T...

journal_title：Biochemical and biophysical research communications

authors： Taştan Bishop AO,Sewell T

更新日期：2006-04-28 00:00:00

abstract：:The signal transduction of human 12(S)-lipoxygenase and the regulation of gene activation, induced by epidermal growth factor (EGF), are discussed in this review article. Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites resid...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Chen BK

更新日期：2005-12-09 00:00:00

abstract：:Two forms of human placental alkaline phosphatase have been purified to homogeneity utilizing high performance liquid chromatography. Both have the same amino acid composition but they differ in their carbohydrate substituents. Sequence data indicate that the two forms are identical for the first forty two residues fr...

journal_title：Biochemical and biophysical research communications

authors： Ezra E,Blacher R,Udenfriend S

更新日期：1983-11-15 00:00:00

abstract：:Vitronectin immobilized onto polystyrene microtiter wells was demonstrated to specifically bind plasminogen in a concentration-dependent manner, yielding an estimated KD = 0.4 microM. Heparin only moderately interfered with the vitronectin-plasminogen interaction, whereas high concentrations of 6-amino-hexanoic acid i...

journal_title：Biochemical and biophysical research communications

authors： Preissner KT

更新日期：1990-05-16 00:00:00

abstract：:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 g...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

更新日期：2006-10-06 00:00:00

abstract：:Glycosaminoglycans were prepared as salts of different divalent cations and tested as donors in bovine testicular hyaluronidase catalyzed transglycosylation reactions. All of the metal cations examined had similar binding efficiency of divalent cations to hyaluronan. However, cations bound with different efficiencies ...

journal_title：Biochemical and biophysical research communications

authors： Kakizaki I,Nukatsuka I,Takagaki K,Majima M,Iwafune M,Suto S,Endo M

更新日期：2011-03-11 00:00:00

abstract：:Bovine brain-derived growth factor (BDGF) is a approximately 16-17 kD polypeptide mitogen with a broad spectrum of cell specificity. Using a highly specific mouse polyclonal anti-BDGF antiserum for indirect immunoperoxidase and immunofluorescent stainings, BDGF was found to be specifically localized in the neurons of ...

journal_title：Biochemical and biophysical research communications

authors： Huang SS,Tsai CC,Adams SP,Huang JS

更新日期：1987-04-14 00:00:00

abstract：:Structural determinants of L-[(3)H]nicotine binding to synthetic peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha subunits were invesitigated by equilibrium binding analysis. Two binding components were detected, one of low affinity (K(d) approximately 1.5 microM) that did not differ sign...

journal_title：Biochemical and biophysical research communications

authors： Lentz TL

更新日期：2000-02-16 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor 2 (TRAF2) has been demonstrated that it plays a significant role in cell death receptor signal transduction. The purpose of this study was to investigate the expression of TRAF2 and its possible role in FJOA. We observed an up-regulation of TRAF2 in FJOA by immunohistoc...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Zhang J,Wu C,Guo X,Chen C,Bao G,Sun Y,Chen J,Xue P,Xu G,Cui Z

更新日期：2018-09-10 00:00:00

abstract：:Interaction of P2X7 receptor with P2X4 receptor has recently been suggested, but it remains unclear whether P2X4 receptor is involved in P2X7 receptor-mediated events, such as cell death of macrophages induced by high concentrations of extracellular ATP. Here, we present evidence that P2X4 receptor does play a role in...

journal_title：Biochemical and biophysical research communications

authors： Kawano A,Tsukimoto M,Noguchi T,Hotta N,Harada H,Takenouchi T,Kitani H,Kojima S

更新日期：2012-03-09 00:00:00

abstract：:Small GTP-binding proteins of the Ras and Rho family participate in various important signalling pathways. Large clostridial cytotoxins inactivate GTPases by UDP-glucosylation. Using Clostridium difficile toxin B-10463 (TcdB) for inactivation of Rho proteins (RhoA/Rac/Cdc42) and Clostridium sordellii lethal toxin-1522...

journal_title：Biochemical and biophysical research communications

authors： Hippenstiel S,Kratz T,Krüll M,Seybold J,von Eichel-Streiber C,Suttorp N

更新日期：1998-04-28 00:00:00

abstract：:Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family. We previously identified 446-533 amino acids of DISC1 as the kendrin-binding region by means of a ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu S,Matsuzaki S,Hattori T,Kumamoto N,Miyoshi K,Katayama T,Tohyama M

更新日期：2008-12-26 00:00:00

abstract：:We studied the subcellular distribution and the properties of [3H] mepyramine binding in the porcine vascular smooth muscle. A close correlation was observed between the specific binding activity of [3H] mepyramine and the extent of the enrichment of sarcolemmal marker enzyme in 4 subfractions obtained by sucrose dens...

journal_title：Biochemical and biophysical research communications

authors： Nishimura J,Kanaide H,Miwa N,Nakamura M

更新日期：1985-01-16 00:00:00

abstract：:Depending on culture in either "low Ca++" (0.25 mM) or "normal Ca++" (1.8 mM) medium, human colon adenocarcinoma-derived CaCo-2 cells exhibit differential sensitivity to the antiproliferative action of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and of two side-chain modified analogs, 1,25S,26-trihydroxy-delta 22-vitamin D...

journal_title：Biochemical and biophysical research communications

authors： Cross HS,Huber C,Peterlik M

更新日期：1991-08-30 00:00:00

abstract：:We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a h...

journal_title：Biochemical and biophysical research communications

authors： Gantz I,Shimoto Y,Konda Y,Miwa H,Dickinson CJ,Yamada T

更新日期：1994-05-16 00:00:00

abstract：:The Vpr protein of human immunodeficiency virus type 1 (HIV-1) is incorporated into the virion by the Gag polyprotein precursor Pr55gag. The importance of the p6gag sequence at the C-terminal end of Pr55gag has a crucial role in Vpr incorporation. To identify the Gag sequences directly involved in Vpr binding, we comp...

journal_title：Biochemical and biophysical research communications

authors： Li MS,Garcia-Asua G,Bhattacharyya U,Mascagni P,Austen BM,Roberts MM

更新日期：1996-01-05 00:00:00

abstract：:2'-Deoxycoformycin (dCF), a specific and potent inhibitor of adenosine deaminase, has demonstrated significant antitumor effect on lymphoid malignancies. The drug induced functional and morphologic differentiation of myeloid leukemia cells in combination with 2'-deoxyadenosine (dAd), but not dCF alone. NB4, a cell lin...

journal_title：Biochemical and biophysical research communications

authors： Niitsu N,Umeda M,Honma Y

更新日期：1997-09-08 00:00:00

abstract：:Histone tail domains play important roles in cellular processes, such as replication, transcription, and chromosome condensation. Histone H2A has one central and two tail domains, and their functions have mainly been studied from a biochemical perspective. In addition, analyses based on visualization have been employe...

journal_title：Biochemical and biophysical research communications

authors： Higashi T,Matsunaga S,Isobe K,Morimoto A,Shimada T,Kataoka S,Watanabe W,Uchiyama S,Itoh K,Fukui K

更新日期：2007-06-08 00:00:00