Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses.

Abstract:

:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necrosis factor receptor associated factor-2 and -3 mediated all those responses. However, activation pattern of mitogen activated protein kinases was different. Immunoglobulin M-mediated apoptosis was inhibited by CD40-mediated signal that activated c-Jun aminoterminal kinase synergistically. While, CD40 stimulus through the 10 amino acid segment alone that induced cell aggregation and proliferation resulted in activation of extracellular signal-regulated protein kinase 2.

authors

Hara T,Murakami M,Maeda H,Hibi M,Uede T

doi

10.1006/bbrc.1997.6343

subject

Has Abstract

pub_date

1997-04-07 00:00:00

pages

187-92

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96343-9

journal_volume

233

pub_type

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