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The involvement of molybdenum in life.

Abstract：

:Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element. It also functions in a few extremely important oxygen-atom transfer reactions at low redox potential. This review poses the question "Why does life depend upon molybdenum?" The answer has to be based upon the availability of the element and on chemical superiority in carrying out the essential tasks. We illustrate here the peculiarities of molybdenum chemistry and how they have become part of certain enzymes. The uptake and incorporation of molybdenum are dependent on its availability, selective pumps, and carriers (chaperones), but 4.5 x 10(9) years ago molybdenum was not available when both tungsten and vanadium or even iron were possibly used in its place. While these possibilities are explored, they leave many unanswered questions concerning the selection today of molybdenum.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Williams RJ,Fraústo da Silva JJ

doi

10.1006/bbrc.2002.6518

subject

Has Abstract

pub_date

2002-03-29 00:00:00

pages

293-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X02965186

journal_volume

292

pub_type

杂志文章,评审

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