Abstract:
:The modification of chromatin structure is increasingly recognized to be an important facet of transcriptional regulation. Here, we report that Brahma-related gene 1 (BRG1), a chromatin remodeling enzyme, plays a crucial role in IFN-γ-induced TRIM22 expression. Our results showed that IFN-γ failed to induce TRIM22 expression in BRG1-deficient SW-13 cells, and reconstitution of BRG1 in this cell line could restore IFN-γ induction of TRIM22. Furthermore, it was revealed that BRG1 absence, per se, did not impair IFN-γ-induced IRF-1 expression, but blocked its access to TRIM22 promoter, and BRG1-dependent induction of TRIM22 perfectly correlated with BRG1-dependent recruitment of IRF-1 to TRIM22 promoter. We also found that the DNA-dependent ATPase domain of BRG1 was required for TRIM22 expression and IRF-1 recruitment in response to IFN-γ stimulation, suggesting that BRG1-mediated chromatin remodeling is critical for the IFN-γ-inducibility of TRIM22 gene.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Wang Y,Gao B,Xu W,Xiong Sdoi
10.1016/j.bbrc.2011.06.022subject
Has Abstractpub_date
2011-07-08 00:00:00pages
549-54issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(11)00980-6journal_volume
410pub_type
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