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Identification of renin and renin messenger RNA sequence in rat ovary and uterus.

Abstract：

:An increase in plasma prorenin during pregnancy suggests that prorenin might be synthesized in the ovary and the secretion of renin or prorenin may be stimulated by an ovarian steroid-mediated process. Recently, renin and angiotensinogen have been identified in human ovarian follicular fluid. However, there is considerable controversy over whether renin is synthesized in the ovary or derived from circulation. In the present study, we confirmed the presence of renin and renin mRNA in rat ovary and uterus by Northern blot analysis with rat renin cRNA as a hybridization probe. Our data show that ovarian or uterine renin is synthesized in the same cells. This suggests that the function of renin might be closely linked to the reproductive process.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim S,Shinjo M,Fukamizu A,Miyazaki H,Usuki S,Murakami K

doi

10.1016/0006-291x(87)90466-9

subject

Has Abstract

pub_date

1987-01-15 00:00:00

pages

169-75

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90466-9

journal_volume

142

pub_type

杂志文章

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