当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes.

TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes.

Abstract：

:TAZ (transcriptional co-activator with PDZ binding motif) is a transcriptional modulator of mesenchymal stem cell differentiation. We have found that TAZ was expressed in postconfluent 3T3-L1 preadipocytes and downregulated during differentiation. Downregulation of TAZ was specifically mediated by dexamethasone (DEX), one component of induction cocktails routinely used in adipocyte differentiation. DEX repressed the transcription of TAZ by direct binding of the glucocorticoid receptor (GR) to the GR binding element in its promoter. More importantly, overexpression of TAZ inhibited adipogenesis and promoted the trans-differentiation of preadipocytes into osteocytes. This establishes a new functional interaction between DEX and TAZ that contributes to the mechanism of adipogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

He Q,Huang HY,Zhang YY,Li X,Qian SW,Tang QQ

doi

10.1016/j.bbrc.2012.02.074

subject

Has Abstract

pub_date

2012-03-16 00:00:00

pages

573-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00307-5

journal_volume

419

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Tropylium tetrafluoroborate, a novel substrate for aldehyde oxidase.

    abstract：:The stabilized carbonium ion salt, tropylium tetrafluoroborate, was oxidized to tropone (cycloheptatrienone) by rabbit liver aldehyde oxidase but not by the closely related molybdenum hydroxylase, xanthine oxidase. The tropylium cation is an aromatic hydrocarbon which lacks the aldehyde, imine, or iminium functional g...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90775-8

    authors： Banks RB,Barnett SD

    更新日期：1986-10-30 00:00:00

  • Rhodamine 123 inhibits import of rat liver mitochondrial transhydrogenase.

    abstract：:Rhodamine 123, a laser dye, has been demonstrated to inhibit import of the precursor to pyridine dinucleotide transhydrogenase into mitochondria in rat liver cells. When rat hepatocytes were labeled with 35[S] methionine in the presence of 0.4 mM rhodamine 123, the precursor to transhydrogenase was found to have a hal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80534-x

    authors： Lubin IM,Wu LN,Wuthier RE,Fisher RR

    更新日期：1987-04-14 00:00:00

  • Structural and biochemical insights into inhibition of human primase by citrate.

    abstract：:The eukaryotic primase/polymerase complex synthesizes approximately 107 primers, one per Okazaki fragment, during the replication of mammalian chromosomes, which contain 109 base pairs. Primase catalyzes the synthesis of a short RNA segment to a single-stranded DNA template. Primase is important in DNA replication bec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.11.047

    authors： Lee JG,Park KR,An JY,Kang JY,Shen H,Wang J,Eom SH

    更新日期：2018-12-09 00:00:00

  • Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway.

    abstract：:Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-linked fucose to the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.03.062

    authors： Ma L,Dong P,Liu L,Gao Q,Duan M,Zhang S,Chen S,Xue R,Wang X

    更新日期：2016-04-29 00:00:00

  • Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain.

    abstract：:We report the half-lives for two proteins involved in the regulation of intracellular calcium in the brain: the plasma membrane Ca-ATPase and its regulatory protein, calmodulin. [14C]-labeled leucine was injected into seven month old adult Fischer 344 rats and the time-dependent appearance and loss of radioactivity wa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7105

    authors： Ferrington DA,Chen X,Krainev AG,Michaelis EK,Bigelow DJ

    更新日期：1997-08-08 00:00:00

  • Expression and localization of regenerating gene I in a rat liver regeneration model.

    abstract：:Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells. We examined Reg I expression in the regenerating liver of a rat model that had been administered 2-acetylaminofluorene and treated with 70% partial hepatectomy (2-AAF/PH model), where hepatocyte and cholang...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.126

    authors： Wang J,Koyota S,Zhou X,Ueno Y,Ma L,Kawagoe M,Koizumi Y,Okamoto H,Sugiyama T

    更新日期：2009-03-13 00:00:00

  • Single bout of running exercise changes LC3-II expression in rat cardiac muscle.

    abstract：:Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.09.152

    authors： Ogura Y,Iemitsu M,Naito H,Kakigi R,Kakehashi C,Maeda S,Akema T

    更新日期：2011-11-04 00:00:00

  • Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7 interaction via PI3K/Akt pathway and is involved in CCL19-driven BMSCs migration.

    abstract：:C-C chemokine receptor 7 (CCR7) and its ligands CCL19 contributes to the directional migration of certain cancer cell lines, but its role in the migration of BMSCs remains vague. The aim of this study was to determine the possible interaction between CCL19-induced conditions and matrix metalloproteinases-9 (MMP9) expr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.07.112

    authors： Zhang W,Tu G,Lv C,Long J,Cong L,Han Y

    更新日期：2014-08-22 00:00:00

  • Protein synthesis inhibition induces proteasome assembly and function.

    abstract：:Protein synthesis and degradation balance have a crucial role in maintenance of cellular homeostasis and function. The ubiquitin-proteasome system is one of the major cellular proteolytic machineries responsible for the removal of normal, abnormal, denatured or in general damaged proteins. Proteasome is a multisubunit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.04.114

    authors： Sakellari M,Chondrogianni N,Gonos ES

    更新日期：2019-06-18 00:00:00

  • Neuronal expression of a Caenorhabditis elegans elav-like gene and the effect of its ectopic expression.

    abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0957

    authors： Fujita M,Kawano T,Ohta A,Sakamoto H

    更新日期：1999-07-14 00:00:00

  • miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4.

    abstract：:microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.056

    authors： Chen L,Tang Y,Wang J,Yan Z,Xu R

    更新日期：2013-06-14 00:00:00

  • Characterisation of progestins used in hormonal contraception and progesterone via the progesterone receptor.

    abstract：:Different progestogens are widely used in hormonal therapy and mediate their therapeutic actions via the progesterone receptor (PR). Little published data exist on their relative efficacies and potencies via the PR, while those available may be confounded by off-target receptors, different methodologies and model syst...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.09.058

    authors： Enfield K,Cartwright M,Toit RL,Avenant C,Africander D,Hapgood JP

    更新日期：2020-12-17 00:00:00

  • Sequencing and characterization of the human thiazide-sensitive Na-Cl cotransporter (SLC12A3) gene promoter.

    abstract：:The thiazide-sensitive Na-Cl cotransporter SLC12A3 displays expression restricted to distal convoluted tubule cells where it catalyzes the uptake of sodium and chloride through the apical membrane. We sequenced 1959 bp of the 5' flanking region of human SLC12A3, located the area of transcription initiation, and used d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4673

    authors： MacKenzie S,Vaitkevicius H,Lockette W

    更新日期：2001-04-13 00:00:00

  • Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay.

    abstract：:Considering the number of cytosolic proteins associated with many diseases, development of cytosol-penetrating molecules from outside of living cells is highly in demand. To gain access to the cytosol after cellular uptake, cell-penetrating molecules should be released from intermediate endosomes prior to the lysosoma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.066

    authors： Kim JS,Choi DK,Park SW,Shin SM,Bae J,Kim DM,Yoo TH,Kim YS

    更新日期：2015-11-27 00:00:00

  • Multi-strand binding of nuclear factors to a repressor of mouse mammary tumor virus transcription can be distinguished kinetically.

    abstract：:NRE1 is a DNA sequence element in the long terminal repeat of mouse mammary tumor virus that represses viral transcription in mature T cells. In addition to double-stranded binding activity, factors in Jurkat T cell nuclear extracts bind specifically to each of the two single-strands of NRE1. Here we show that binding...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1514

    authors： Rodda DJ,Giffin W,Haché RJ

    更新日期：1995-04-06 00:00:00

  • Regulation of brain endothelial cells migration and angiogenesis by P-glycoprotein/caveolin-1 interaction.

    abstract：:We have investigated the involvement of P-glycoprotein (P-gp)/caveolin-1 interaction in the regulation of brain endothelial cells (EC) migration and tubulogenesis. P-gp overexpression in MDCK-MDR cells was correlated with enhanced cell migration whereas treatment with P-gp inhibitors CsA or PSC833 reduced it. Transfec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.012

    authors： Barakat S,Turcotte S,Demeule M,Lachambre MP,Régina A,Baggetto LG,Béliveau R

    更新日期：2008-08-01 00:00:00

  • Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.

    abstract：:Staurosporine (STAR), a potent protein kinase C (PKC) antagonist, was found to modulate the chemoattractant-induced respiratory burst of human polymorphonuclear leukocytes (PMNs) according to drug concentration. Low STAR concentrations from 10 to 200 nM potentiated the N-formyl-methionyl-leucyl-phenylalanine (fMLP) an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91675-i

    authors： Combadière C,Hakim J,Giroud JP,Périanin A

    更新日期：1990-04-16 00:00:00

  • Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model.

    abstract：:Recurrent osteosarcoma is a chemotherapy-resistant disease. Individualized precision therapy is needed for this disease. Toward this goal, we have developed the patient-derived othotopic xenograft (PDOX) mouse model of all major cancer types including osteosarcoma. Synergistic efficacy of trabectedin (TRAB) and irinot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.191

    authors： Higuchi T,Miyake K,Oshiro H,Sugisawa N,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Chawla SP,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

    更新日期：2019-05-28 00:00:00

  • Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping.

    abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.092

    authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

    更新日期：2007-11-03 00:00:00

  • NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma.

    abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.037

    authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

    更新日期：2017-06-17 00:00:00

  • Specific desensitization of actin polymerization of bovine platelets.

    abstract：:Polymerization of actin induced by activation of platelets was investigated using deoxyribonuclease I inhibition assay. When platelets were activated with ADP or 5-hydroxytryptamine, actin was polymerized quickly followed by rapid depolymerization to the initial level. Reactivation with the same agonist, however, did ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80184-9

    authors： Imada T,Kikuchi T,Shimada H,Inada Y,Saito Y

    更新日期：1984-05-16 00:00:00

  • Analysis by in vitro mutagenesis of PP2A alpha okadaic acid responsive sequences.

    abstract：:It has been shown that the protein serine/threonine phosphatase type 2A alpha catalytic subunit (PP2A alpha) has a mutation consisting of a glycine substitution for cysteine at 269 in the okadaic acid resistant variant of CHO cells, and that the mutant protein is resistant to okadaic acid (Shima, H. et al. Proc. Natl....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2317

    authors： Kaneko S,Shima H,Amagasa T,Takagi M,Sugimura T,Nagao M

    更新日期：1995-09-14 00:00:00

  • Identification of gene expression modifications in myostatin-stimulated myoblasts.

    abstract：:Myostatin belongs to the transforming growth factor beta superfamily and has been shown to function as an inhibitor of skeletal muscle proliferation and differentiation. To gain insight into the molecular mechanisms of myostatin function during myogenesis, differential display reverse transcription PCR was employed to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.11.096

    authors： Yang W,Zhang Y,Ma G,Zhao X,Chen Y,Zhu D

    更新日期：2005-01-21 00:00:00

  • DNA damage, lysosomal degradation and Bcl-xL deamidation in doxycycline- and minocycline-induced cell death in the K562 leukemic cell line.

    abstract：:We investigated mechanisms of cytotoxicity induced by doxycycline (doxy) and minocycline (mino) in the chronic myeloid leukemia K562 cell line. Doxy and mino induced cell death in exposure-dependent manner. While annexin V/propidium iodide staining was consistent with apoptosis, the morphological changes in Giemsa sta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.05.043

    authors： Fares M,Abedi-Valugerdi M,Hassan M,Potácová Z

    更新日期：2015-07-31 00:00:00

  • Towards stem cell replacement therapies for Parkinson's disease.

    abstract：:Current therapeutic approaches for Parkinson's disease (PD) provide symptomatic relief but none of them change the course of disease. There is therefore a clear need for regenerative and cell replacement therapies (CRT). However, CRT faces several important challenges. First, the main symptoms of PD result from the lo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2010.04.037

    authors： Arenas E

    更新日期：2010-05-21 00:00:00

  • Norepinephrine induces rapid and long-lasting phosphorylation and redistribution of connexin 43 in cortical astrocytes.

    abstract：:Norepinephrine (NE) modulates brain functions depending on both the internal and external environment. While the neuromodulatory actions of NE have been well characterized, the response and involvement of cortical astrocytes to physiological noradrenergic systems remain largely unknown, especially at the molecular lev...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.09.021

    authors： Nuriya M,Morita A,Shinotsuka T,Yamada T,Yasui M

    更新日期：2018-10-12 00:00:00

  • Requirement for Crk and CrkL during postnatal lens development.

    abstract：:The Crk and CrkL adaptor proteins have SH2 and SH3 domains and play essential overlapping, as well as distinct, roles in many biological processes, ranging from cell structure and motility to proliferation. Conditional ablation of both Crk and CrkL in neuronal progenitor cells, using a Nestin-Cre transgene, resulted i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.06.108

    authors： Park T,Curran T

    更新日期：2020-08-27 00:00:00

  • Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components.

    abstract：:Exosomes, the natural vehicles of various biological molecules, have been examined in several research fields including drug delivery. Although understanding of the biological functions of exosomes has increased, how exosomes are transported between cells remains unclear. We hypothesized that cell tropism is important...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.12.015

    authors： Toda Y,Takata K,Nakagawa Y,Kawakami H,Fujioka S,Kobayashi K,Hattori Y,Kitamura Y,Akaji K,Ashihara E

    更新日期：2015-01-16 00:00:00

  • Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.

    abstract：:The molecular forms of endothelin (ET) related peptides were investigated in porcine brain by using high performance liquid chromatography coupled with three specific radioimmunoassays. ET-1 and its oxidized form were isolated and sequenced as in the case of porcine spinal cord. A very small amount of big ET-1 (1-39) ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91760-9

    authors： Shinmi O,Kimura S,Sawamura T,Sugita Y,Yoshizawa T,Uchiyama Y,Yanagisawa M,Goto K,Masaki T,Kanazawa I

    更新日期：1989-10-16 00:00:00

  • Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay.

    abstract：:The protein misfolding cyclic amplification (PMCA) assay allows for detection of prion protein misfolding activity in tissues and fluids from sheep with scrapie where it was previously undetected by conventional western blot and immunohistochemistry assays. Studies of goats with scrapie have yet to take advantage of P...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.034

    authors： Madsen-Bouterse SA,Zhuang D,O'Rourke KI,Schneider DA

    更新日期：2012-07-13 00:00:00