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Identification of gene expression modifications in myostatin-stimulated myoblasts.

Abstract：

:Myostatin belongs to the transforming growth factor beta superfamily and has been shown to function as an inhibitor of skeletal muscle proliferation and differentiation. To gain insight into the molecular mechanisms of myostatin function during myogenesis, differential display reverse transcription PCR was employed to identify altered gene expressions associated with myostatin inhibitory function in chicken fetal myoblasts (CFMs). In this work, we have identified seven up-regulated and 12 down-regulated genes in myostatin stimulated CFMs. Those genes are involved in myogenic differentiation, cell architecture, energy metabolism, signal transduction, and apoptosis. The down-regulation of muscle creatine kinase B, troponin C, and myosin regulatory light chain is in agreement with the myostatin negative role in myocyte differentiation. In addition, the expression alteration of skeletal muscle-specific cardiac ankyrin repeat protein and the bcl-2 related anti-apoptotic protein Nr-13 suggests possible unique roles for myostatin in regulating myogenesis by controlling cofactors participated transcriptional regulation and apoptosis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yang W,Zhang Y,Ma G,Zhao X,Chen Y,Zhu D

doi

10.1016/j.bbrc.2004.11.096

subject

Has Abstract

pub_date

2005-01-21 00:00:00

pages

660-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02671-3

journal_volume

326

pub_type

杂志文章

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