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Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.

Abstract：

:The molecular forms of endothelin (ET) related peptides were investigated in porcine brain by using high performance liquid chromatography coupled with three specific radioimmunoassays. ET-1 and its oxidized form were isolated and sequenced as in the case of porcine spinal cord. A very small amount of big ET-1 (1-39) and its C-terminal fragment (big ET-1 (22-39] were also detected. Furthermore, immunoreactive (ir)-ET-3 was isolated and sequenced; its partial primary structure was identical to that of human (rat) ET-3. The concentrations of ir-ET-1 and ir-ET-3 in porcine brain were 140 fmol/g tissue and 5 fmol/g tissue, respectively. These results indicate that besides ET-1, ET-3 is a novel neuropeptide in the central nervous system.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shinmi O,Kimura S,Sawamura T,Sugita Y,Yoshizawa T,Uchiyama Y,Yanagisawa M,Goto K,Masaki T,Kanazawa I

doi

10.1016/0006-291x(89)91760-9

subject

Has Abstract

pub_date

1989-10-16 00:00:00

pages

587-93

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91760-9

journal_volume

164

pub_type

杂志文章

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