Expression and characterization of the tau subunit of phosphorylase kinase.

abstract：:Quercetin is one of the most prominent dietary antioxidants. During its antioxidant activity, quercetin becomes oxidized into its o-quinone/quinone methide QQ. QQ is toxic since it instantaneously reacts with thiols of, e.g., proteins. In cells, QQ will initially form an adduct with glutathione (GSH), giving GSQ. We h...

journal_title：Biochemical and biophysical research communications

authors： Boots AW,Balk JM,Bast A,Haenen GR

更新日期：2005-12-16 00:00:00

abstract：:The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin. The material was reduced and alkylated and the A- and the B-chain were separated by reversed phase chromatography and subjected to Edman degradation and amino acid analysis. It was shown that the A-chain c...

journal_title：Biochemical and biophysical research communications

authors： Hellman U,Wernstedt C,Westermark P,O'Brien TD,Rathbun WB,Johnson KH

更新日期：1990-06-15 00:00:00

abstract：:Transglutaminase 2 (TGase 2) is a bifunctional enzyme that catalyzes calcium-dependent transamidation and GTP binding/hydrolysis. The transamidation activity is proposed to be associated with several neurodegenerative disorders such as Alzheimer's and Hungtinton's disease. However, the regulation mechanism by which TG...

journal_title：Biochemical and biophysical research communications

authors： Jeon JH,Cho SY,Kim CW,Shin DM,Kweon JC,Choi KH,Park SC,Kim IG

更新日期：2002-06-21 00:00:00

abstract：:Recurrent osteosarcoma is a chemotherapy-resistant disease. Individualized precision therapy is needed for this disease. Toward this goal, we have developed the patient-derived othotopic xenograft (PDOX) mouse model of all major cancer types including osteosarcoma. Synergistic efficacy of trabectedin (TRAB) and irinot...

journal_title：Biochemical and biophysical research communications

authors： Higuchi T,Miyake K,Oshiro H,Sugisawa N,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Chawla SP,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2019-05-28 00:00:00

abstract：:p73 is a member of the p53 family of transcription factors which plays an essential role in tumor suppression. p73 is associated with the sensitivity of cancer cells to chemotherapy and the prognosis of many cancers. In this study, we showed the ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiqu...

journal_title：Biochemical and biophysical research communications

authors： Min B,Ryu J,Chi SW,Yi GS

更新日期：2015-11-13 00:00:00

abstract：:Protein phosphorylation, governed by kinases and phosphatases, plays a pivotal role in enormous cellular signaling pathways. Although PPP family of serine/threonine phosphatases have been involved in multiplication and growth of trypanosomatid parasites, but comprehensive knowledge is still very limited. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Qureshi R,Jakkula P,Sagurthi SR,Qureshi IA

更新日期：2019-08-27 00:00:00

abstract：:Tumor-induced lymphangiogenesis, a major conduit for cancer cell dissemination from the primary tumor site to lymph nodes and beyond, eventually leads to metastasis in cancer patients. Given the recent evidence revealing that the suppression of ELK3 inhibits the metastasis of triple-negative breast cancer cells, we ai...

journal_title：Biochemical and biophysical research communications

authors： Oh N,Park JI,Park JH,Kim KS,Lee DR,Park KS

更新日期：2017-03-18 00:00:00

abstract：:Previous studies have shown that DNA strand breaks are an early consequence of nitric oxide toxicity in pancreatic islet cells. We show here that exposure of islet cells to chemical NO donors causes the formation of ADP-ribose polymers in cell nuclei, with concomitant depletion of intracellular NAD+. Islet cell lysis ...

journal_title：Biochemical and biophysical research communications

authors： Radons J,Heller B,Bürkle A,Hartmann B,Rodriguez ML,Kröncke KD,Burkart V,Kolb H

更新日期：1994-03-30 00:00:00

abstract：:Ac-D-Trp1,3, D-Cpa2, D-Lys6, D-Ala10-GnRH has been prepared by solid phase synthesis. The peptide was found to completely inhibit ovulation when administered on proestrus day in a dose of 1.5 microgram/rat, s.c. The peptide completely inhibited ovulation for a period corresponding to three to four cycles when administ...

journal_title：Biochemical and biophysical research communications

authors： Kovacs M,Mezo I,Flerko B,Teplan I,Nikolics K

更新日期：1984-01-13 00:00:00

abstract：:The effect of 1-bromlalkanes on intracellular glutathione (GSH) was studied in freshly isolated rat hepatocytes. Treatment of cells with bromoalkanes depleted cellular GSH levels without causing cytotoxicity. The extent of GSH depletion was directly proportional to the concentration and increasing chain length of 1-br...

journal_title：Biochemical and biophysical research communications

authors： Khan S,O'Brien PJ

更新日期：1991-08-30 00:00:00

abstract：:Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Th...

journal_title：Biochemical and biophysical research communications

authors： Lim W,Bae H,Sohn JY,Jeong W,Kim SH,Song G

更新日期：2015-01-02 00:00:00

abstract：:A polyclonal antiserum raised against purified alpha-agglutinin was made specific for alpha-agglutinin after adsorption with a cells. The adsorbed antiserum identified alpha-agglutinin peptides on Western blots and bound to cell surface alpha-agglutinin, inhibiting the binding of alpha cells to a cells. Using the anti...

journal_title：Biochemical and biophysical research communications

authors： Wojciechowicz D,Lipke PN

更新日期：1989-05-30 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) belongs to a nuclear receptor super family that functions as a master regulator of adipocyte differentiation. PPAR gamma binds its DNA response element together with a partner, retinoid X receptor (RXR), in fat cells. Five RXR ligands (HX600, HX630, DA022, ...

journal_title：Biochemical and biophysical research communications

authors： Sato M,Yajima Y,Kawashima S,Tanaka K,Kagechika H

更新日期：2001-01-26 00:00:00

abstract：:Poly(ADP-ribose) polymerase (ADPRP) is a nuclear enzyme that transfers ADP-ribose from NAD+ to diverse nuclear proteins. Previously, the function of ADPRP was considered to relate exclusively to its catalytic activity. However, recent experiments have shown that ADPRP is actually an abundant DNA-binding protein, and t...

journal_title：Biochemical and biophysical research communications

authors： Nobori T,Yamanaka H,Carson DA

更新日期：1989-09-15 00:00:00

abstract：:Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of transformed myeloid cells. It attacks artificially expressing activated c-Kit myeloid progenitor FD...

journal_title：Biochemical and biophysical research communications

authors： Ilinskaya ON,Zelenikhin PV,Petrushanko IY,Mitkevich VA,Prassolov VS,Makarov AA

更新日期：2007-10-05 00:00:00

abstract：:The effect of transforming growth factor-beta (TGF-beta) on the endogenous protein phosphorylation caused by phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), was examined in primary cultured mouse epidermal cells. PMA markedly stimulates phosphorylation of endogenous proteins, i.e. ...

journal_title：Biochemical and biophysical research communications

authors： Nishikawa K,Yamamoto S,Nagumo H,Otsuka C,Kato R

更新日期：1993-05-28 00:00:00

abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

journal_title：Biochemical and biophysical research communications

authors： Omkumar RV,Gaikwad AS,Ramasarma T

更新日期：1992-05-15 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:The growth of DU-145 human prostate carcinoma cells is reduced to 50% of control by 1 X 10(-6) M to 2 X 10(-6) M selenium and to 2% of control at 10(-4)M selenium. These cells show greater sensitivity to inhibition of growth or DNA synthesis by selenium than human W1-38 and HeLa cells and mouse mammary tumor cells. It...

journal_title：Biochemical and biophysical research communications

authors： Webber MM,Perez-Ripoll EA,James GT

更新日期：1985-07-31 00:00:00

abstract：:TRIM62, also named DEAR1, is a member of the TRIM/RBCC family, which includes proteins with conserved RING finger, B-box and coiled-coil domains. Several reports have identified a role for this family in cancer, retroviral infection and innate immunity. In this study, the E3 ubiquitin ligase activity and subcellular l...

journal_title：Biochemical and biophysical research communications

authors： Huang F,Xiao H,Sun BL,Yang RG

更新日期：2013-03-08 00:00:00

abstract：:It is well recognized that phorbol 12,13-dibutyrate (PDBu)-activated PKC directly phosphorylates myristoylated alanine-rich C kinase substrate (MARCKS), whose phosphorylation is used as a marker of PKC activation. However, in SH-SY5Y neuroblastoma cells, Western blotting analyses revealed that Rho-associated coiled-co...

journal_title：Biochemical and biophysical research communications

authors： Tanabe A,Kamisuki Y,Hidaka H,Suzuki M,Negishi M,Takuwa Y

更新日期：2006-06-23 00:00:00

abstract：:FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing ...

journal_title：Biochemical and biophysical research communications

authors： Ma C,Peng C,Lu X,Ding X,Zhang S,Zou X,Zhang X

更新日期：2015-03-06 00:00:00

abstract：:Two multidrug-resistant human leukemic CCRF-CEM sublines (CEM/VCR R and CEM/VLB100) were significantly more resistant to tetracycline, a hydrophilic antibiotic, than parental cells (P < 0.001). Verapamil and cyclosporin A completely reversed tetracycline resistance in CEM/VCR R cells, which also accumulated and retain...

journal_title：Biochemical and biophysical research communications

authors： Kavallaris M,Madafiglio J,Norris MD,Haber M

更新日期：1993-01-15 00:00:00

abstract：:Increased protein tyrosyl phosphorylation in response to growth factors has been assumed to be solely due to activation of protein tyrosine kinases (PTKs). We report that total cellular protein tyrosine phosphatase (PTPase) activity declined in MDA-MB 468 breast carcinoma cells exposed to epidermal growth factor (EGF)...

journal_title：Biochemical and biophysical research communications

authors： Mishra S,Hamburger AW

更新日期：1993-03-31 00:00:00

abstract：:The functional importance of mitochondrial protein translation has been recently documented in the context of various cancers but not renal cell carcinoma (RCC). In lines with these efforts, our work demonstrates that mitochondrial translation inhibition by tigecycline or depletion of EF-Tu mitochondrial translation f...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Ao J,Yu D,Rao T,Ruan Y,Yao X

更新日期：2017-08-26 00:00:00

abstract：:Several rat liver cytochromes P-450 have been substantially purified in a one-step immunoadsorption procedure using Sepharose-bound monoclonal antibodies (MAbs) to the major forms of rat liver cytochrome P-450 induced by 3-methylcholanthrene and phenobarbital (MC-P-450 and PB-P-450, respectively). When mixed with solu...

journal_title：Biochemical and biophysical research communications

authors： Friedman FK,Robinson RC,Park SS,Gelboin HV

更新日期：1983-11-15 00:00:00

abstract：:alpha-Crystallin, a major protein of the lens, is known to have chaperone activity to protect other proteins against thermal aggregation. Heat-induced structural change of alpha-crystallin was previously shown to increase its chaperone activity. In this report, we studied the thermal reversibility of alpha-crystallin ...

journal_title：Biochemical and biophysical research communications

authors： Lee JS,Satoh T,Shinoda H,Samejima T,Wu SH,Chiou SH

更新日期：1997-08-18 00:00:00

abstract：:Germline stem cells (GSCs) are attractive biological models because of their strict control on pluripotency gene expression, and their potential for huge epigenetic changes in a short period of time. Few data exists on the cooperative impact of GSC-specific genes on differentiated cells. In this study, we over-express...

journal_title：Biochemical and biophysical research communications

authors： Farshchian M,Matin MM,Bahrami M,Geerts D,Dastpak M,Shahriyari M,Tajeran M,Mirahmadi M,Bahrami AR

更新日期：2016-11-25 00:00:00

abstract：:In this study, we established an in vitro hypoxic system driven by a self-regulated chemical reaction that proved effective for cell culture. The hypoxic device was modified from a 1.5 L polypropylene preservation box normally employed for food storage. Pyrogallic acid, sodium hydroxide, and sodium carbonate were diss...

journal_title：Biochemical and biophysical research communications

authors： Han N,Wang Z,Wang G,Yu J,Chen C,Huang H,Xu R

更新日期：2018-06-07 00:00:00

abstract：:Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. Understanding the molecular mechanisms underlying placentation facilitates the development of better intervention of this disease. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we found...

journal_title：Biochemical and biophysical research communications

authors： Li Q,Pan Z,Wang X,Gao Z,Ren C,Yang W

更新日期：2014-10-10 00:00:00