Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.

abstract：:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity...

journal_title：Biochemical and biophysical research communications

authors： Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

更新日期：1991-08-15 00:00:00

abstract：:The upstream activating region that controls cellulose-induced expression of the glucose-repressible cellobiohydrolase I gene (UARcb1) of the filamentous fungus Trichoderma reesei is shown to mediate transcription and glucose repression of a reporter gene in Saccharomyces cerevisiae, a unicellular microorganism that l...

journal_title：Biochemical and biophysical research communications

authors： Carraro DM,Ferreira Júnior JR,Schumacher R,Pereira GG,Hollenberg CP,El-Dorry H

更新日期：1998-12-18 00:00:00

abstract：:In T lymphocyte, activation of Kv1.3 channel, the major voltage-dependent K(+) channel, is an essential step for cell proliferation in immune responses. Here, effects of anti-CD3 and anti-CD28 antibodies on Kv1.3 current were examined in three types of human T lymphocyte derived cell lines, Jurkat E6-1, p56lck-kinase ...

journal_title：Biochemical and biophysical research communications

authors： Matsushita Y,Ohya S,Itoda H,Kimura T,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2008-09-12 00:00:00

abstract：:A simple and high yield purification procedure for the isolation of F0F1-ATPase from spinach leaf mitochondria has been developed. This is the first report concerning purification and composition of the plant mitochondrial F0F1-ATPase. The enzyme is selectively extracted from inner membrane vesicles with the zwitterio...

journal_title：Biochemical and biophysical research communications

authors： Hamasur B,Glaser E

更新日期：1990-08-16 00:00:00

abstract：:The development of adipose tissue is a precisely coordinated cellular process, in which both protein-coding and non-coding genes are involved. To characterize the in vivo function of a novel long non-coding RNA (lncRNAs), loss-of-function assays were performed with slincRAD knockdown mice. Down-regulation of slincRAD ...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Bai H,Li J,Liu J,Ma W,Xu B,Xia Q,Wang J,Fan Yi,Du Q

更新日期：2019-06-11 00:00:00

abstract：:When linoleic acid was incubated with the purified potato lipoxygenase under O2 atmosphere, a mixture of 9 and 13-hydroperoxyoctadecadienoic acids was formed. Stereochemical analysis of the respective methyl-hydroxyoctadecadienoic acids revealed that the 9-isomer was in S-configuration whereas 13-hydroxyoctadecadienoi...

journal_title：Biochemical and biophysical research communications

authors： Nikolaev V,Reddanna P,Whelan J,Hildenbrandt G,Reddy CC

更新日期：1990-07-31 00:00:00

abstract：:We previously showed that beta-defensin-1 (BD-1), an anti-microbial peptide, is up-regulated during progressive hyperglycemia in the kidneys of the GK rat [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Biophys. Re...

journal_title：Biochemical and biophysical research communications

authors： Malik AN,Al-Kafaji G

更新日期：2007-02-09 00:00:00

abstract：:Isoprenoids comprise a diverse group of natural products with a broad range of metabolic functions. Isoprenoids are synthesized from prenyl pyrophosphates by prenyltransferases that catalyze the isoprenoid chain-elongation process to different chain lengths. We hereby present the crystal structure of geranylgeranyl py...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kim EJ,Park JB,Kim SW,Kim KJ

更新日期：2019-10-20 00:00:00

abstract：:A neuropeptide was isolated from the corpora cardiaca of the corn earworm moth Heliothis zea, and purified by sequential gradient elution in three reversed phase-high performance liquid chromatographic steps. The primary structure, pGlu-Leu-Thr-Phe-Ser-Ser-Gly-Trp-Gly-Asn-NH2 was determined by automated gas-phase Edma...

journal_title：Biochemical and biophysical research communications

authors： Jaffe H,Raina AK,Riley CT,Fraser BA,Bird TG,Tseng CM,Zhang YS,Hayes DK

更新日期：1988-08-30 00:00:00

abstract：:We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activatio...

journal_title：Biochemical and biophysical research communications

authors： Morishige KI,Inanobe A,Takahashi N,Yoshimoto Y,Kurachi H,Miyake A,Tokunaga Y,Maeda T,Kurachi Y

更新日期：1996-03-18 00:00:00

abstract：:Purified human recombinant interleukin 4 (IL-4) was radio iodinated to high specific radioactivity without loss of biological activity. 125I-IL-4 bound specifically to the Burkitt lymphoma Jijoye cells and other cell lines. Jijoye cells showed a high affinity for 125I-IL-4 (Kd approximately equal to 7 10(-11) M) and d...

journal_title：Biochemical and biophysical research communications

authors： Cabrillat H,Galizzi JP,Djossou O,Arai N,Yokota T,Arai K,Banchereau J

更新日期：1987-12-31 00:00:00

abstract：:To isolate seizure-related genes, we applied differential screening technique to the cDNA library which constructed from primary cultured cerebral cortical cells treated with pentylenetetrazol (PTZ). Northern blotting analysis of mRNA levels in the cerebra after systemic administration of PTZ confirmed the results of ...

journal_title：Biochemical and biophysical research communications

authors： Kajiwara K,Nagawawa H,Shimizu-Nishikawa S,Ookuri T,Kimura M,Sugaya E

更新日期：1996-02-27 00:00:00

abstract：:The mRNA coding for thyroglobulin in cattle homozygous for an autosomal recessive defect of thyroglobulin synthesis was investigated using a recombinant plasmid containing bovine mRNA coding sequence. Total RNA preparations from goiter contained one third of the thyroglobulin mRNA sequences found in normal thyroid tis...

journal_title：Biochemical and biophysical research communications

authors： Ricketts MH,Vandenplas S,van der Walt M,van Jaarsveld PP,Bester AJ,Boyd CD

更新日期：1985-01-16 00:00:00

abstract：:Most formal methods for analyzing the divergent evolution of protein sequences assume a Markov model where position i in a polypeptide chain undergoes amino acid substitution independently from position i + 1. The large number of aligned homologous sequence pairs available from the exhaustive matching of the protein s...

journal_title：Biochemical and biophysical research communications

authors： Gonnet GH,Cohen MA,Benner SA

更新日期：1994-03-15 00:00:00

abstract：:Myostatin belongs to the transforming growth factor beta superfamily and has been shown to function as an inhibitor of skeletal muscle proliferation and differentiation. To gain insight into the molecular mechanisms of myostatin function during myogenesis, differential display reverse transcription PCR was employed to...

journal_title：Biochemical and biophysical research communications

authors： Yang W,Zhang Y,Ma G,Zhao X,Chen Y,Zhu D

更新日期：2005-01-21 00:00:00

abstract：:Autophagy plays a crucial role in a wide array of physiological processes. To uncover the complex regulatory networks and mechanisms underlying basal autophagy, we performed a quantitative proteomics analysis of autophagy-deficient mouse embryonic fibroblast cells (MEFs) using iTRAQ labeling coupled with on-line 2D LC...

journal_title：Biochemical and biophysical research communications

authors： Zhuo C,Ji Y,Chen Z,Kitazato K,Xiang Y,Zhong M,Wang Q,Pei Y,Ju H,Wang Y

更新日期：2013-08-02 00:00:00

abstract：:A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylger...

journal_title：Biochemical and biophysical research communications

authors： Wiemer AJ,Tong H,Swanson KM,Hohl RJ

更新日期：2007-02-23 00:00:00

abstract：:Angiogenesis is a key pathogenic event in hepatic fibrogenesis, which is mediated by activated hepatic stellate cells (HSCs). TNP-470 is a known anti-angiogenic agent in cancer, and in this study, we investigated the regulatory mechanisms of TNP-470 blockage of vascular endothelial growth factor (VEGF) synthesis in ac...

journal_title：Biochemical and biophysical research communications

authors： Wang YQ,Luk JM,Chu AC,Ikeda K,Man K,Kaneda K,Fan ST

更新日期：2006-03-03 00:00:00

abstract：:Phosphofructokinase of rabbit muscle, which is specific for nucleoside triphosphates such as ATP, dissociated and gained the capability to utilize pyrophosphate as phosphoryl donor following incubation with UDP-glucose. The pyrophosphate- and ATP-linked activities of UDP-glucose-treated muscle phosphofructokinase were...

journal_title：Biochemical and biophysical research communications

authors： Wong JH,Balogh A,Buchanan BB

更新日期：1984-06-29 00:00:00

abstract：:Ubiquitylation is an essential posttranslational protein modification that is implicated in a diverse array of cellular functions. Although cells contain eight structurally distinct types of polyubiquitin chains, detailed function of several chain types including K29-linked chains has remained largely unclear. Current...

journal_title：Biochemical and biophysical research communications

authors： Tsuchiya H,Tanaka K,Saeki Y

更新日期：2013-06-28 00:00:00

abstract：:Neuroblastoma (NB) expresses the tyrosine kinase receptors c-Kit, PDGFR-alpha and -beta-targets for STI-571. We investigated a possible combination therapy of STI-571 with retinoic acid (RA) and gamma-irradiation on NB cell viability in vitro. Expression of tyrosine kinase receptors and their ligands was examined in 6...

journal_title：Biochemical and biophysical research communications

authors： Rössler J,Zambrzycka I,Lagodny J,Kontny U,Niemeyer CM

更新日期：2006-04-21 00:00:00

abstract：:Microsomal vesicles prepared from rat adipocytes were immuno-adsorbed to formaldehyde-fixed Staphylococcus aureus cells (Pansorbin) coated with anti-human-erythrocyte-glucose-transporter IgG. More than 75% of the glucose transporter detected was precipitated. The glucose transporter was about 10-fold enriched by the a...

journal_title：Biochemical and biophysical research communications

authors： Ezaki O,Bono N,Itakura H,Kasahara M

更新日期：1989-03-31 00:00:00

abstract：:We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally...

journal_title：Biochemical and biophysical research communications

authors： Yanase Y,Hiragun T,Uchida K,Ishii K,Oomizu S,Suzuki H,Mihara S,Iwamoto K,Matsuo H,Onishi N,Kameyoshi Y,Hide M

更新日期：2009-09-25 00:00:00

abstract：:Phosphate transporters (PHTs) are well-known for their roles in phosphate uptake in plants. However, their actions in imparting plant growth in plants are still not so clear. In our previous study, we observed that maize PHT1 gene ZmPt9 plays a significant role in phosphate uptake. In this study, we further characteri...

journal_title：Biochemical and biophysical research communications

authors： Xu Y,Bao H,Fei H,Zhou W,Li X,Liu F

更新日期：2020-09-19 00:00:00

abstract：:Adenosine, a metabolite of ATP, ubiquitously exists in a wide range of organs and tissues. We previously reported that adenosine was implicated in apoptosis in many cancer cells by extrinsic and/or intrinsic pathways. Here, we found that adenosine suppresses the cell growth by induction of apoptosis of human colonic c...

journal_title：Biochemical and biophysical research communications

authors： Yu S,Hou D,Chen P,Zhang Q,Lv B,Ma Y,Liu F,Liu H,Song EJ,Yang D,Liu J

更新日期：2015-05-08 00:00:00

abstract：:Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Unfortunately, the mechani...

journal_title：Biochemical and biophysical research communications

authors： Hong X,Li S,Li W,Xie M,Wei Z,Guo H,Wei W,Zhang S

更新日期：2019-01-15 00:00:00

abstract：:In the present study, we examined the effects and action mechanisms of cGMP-elevating agents on platelet adhesion to collagen fiber. YC-1, a nitric oxide (NO)-independent activator of soluble guanylate cyclase, inhibited both initial and long-term platelet adhesion to collagen, and the inhibitory effect was potentiate...

journal_title：Biochemical and biophysical research communications

authors： Wu CC,Ko FN,Teng CM

更新日期：1997-02-13 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and potent antibody-dependent cell-mediated cytotoxicity (ADCC) are recommended. Previously, a panel of functional epitopes that can elicit ADCC ef...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Liu M,Ding N,Li Y,Shao J,Zhu M,Xie Z,Sun K

更新日期：2018-09-10 00:00:00

abstract：:The environmental toxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wasting syndrome marked by hypophagia, loss of body fat, changes in intermediary metabolism and death. Use of conventional laboratory animals has not resolved whether or not TCDD affects intermediary metabolism independently of hypophagia. We...

journal_title：Biochemical and biophysical research communications

authors： Lentnek M,Griffith OW,Rifkind AB

更新日期：1991-02-14 00:00:00

abstract：:The refolding kinetics of cobrotoxin (CBTX), a small-molecular-weight ( approximately 7 kDa) all beta-sheet protein, has been monitored using a variety of biophysical techniques. The secondary structure formation and hydrophobic collapse occur as distinct events during the refolding of the protein. Complete secondary ...

journal_title：Biochemical and biophysical research communications

authors： Sivaraman T,Kumar TK,Tu YT,Wang W,Lin WY,Chen HM,Yu C

更新日期：1999-06-24 00:00:00