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Molecular cloning of the rat Tpx-1 responsible for the interaction between spermatogenic and Sertoli cells.

Abstract：

:We previously showed in a primary culture of rat testicular cells that spermatogenic cells specifically bind to somatic Sertoli cells and that this interaction is needed for spermatogenic cells to differentiate in vitro. Adopting an expression cloning procedure, we here isolated a cDNA coding for a spermatogenic cell protein whose expression gave a cultured cell line the ability to bind to Sertoli cells. The protein, 243 amino acids with a putative N-terminal signal peptide and a C-terminal Cys-rich region, turned out to be the rat homologue of a testicular protein called Tpx-1 whose function had yet to be determined. A polyclonal antibody raised against bacterially expressed Tpx-1 significantly inhibited the binding of spermatogenic cells to Sertoli cells. The above results indicated that Tpx-1 is a testicular cell adhesion molecule responsible for the specific interaction between spermatogenic and Sertoli cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Maeda T,Sakashita M,Ohba Y,Nakanishi Y

doi

10.1006/bbrc.1998.8918

subject

Has Abstract

pub_date

1998-07-09 00:00:00

pages

140-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98918-5

journal_volume

248

pub_type

杂志文章

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