Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines.

abstract：:Using affinity chromatography on immobilized transcortin of 125I-labeled, cholate-solubilized plasma membranes of human syncytiotrophoblast, a transcortin-binding protein with a minimal Mr of about 20 kDa has been isolated. It was found to be a sialoglycoprotein with an isoelectric point at pH 4.4 (about 5.0 after the...

journal_title：Biochemical and biophysical research communications

authors： Krupenko SA,Avvakumov GV,Strel'chyonok OA

更新日期：1991-06-14 00:00:00

abstract：:The relative inability of hemopoietic stem cells (HSCs) to reproduce themselves (self-renew) ex vivo imposes substantial limitations on the current use of HSC transplantation. Recently, the transcription factor Zfx has been demonstrated that played an important in controlling the self-renewal of hematopoietic stem cel...

journal_title：Biochemical and biophysical research communications

authors： Xu C,Zhang Y,Jiang H

更新日期：2009-02-13 00:00:00

abstract：:We studied the uptake of Ca2+ in different intracellular Ca2+ pools by use of steady-state measurement of 45Ca2+ in a preparation of digitonin-permeabilized pancreatic acinar cells. The Ca2+ content of all intracellular pools was assessed at different free Ca2+ concentrations between 0.1 and 1 microM. At low Ca2+ conc...

journal_title：Biochemical and biophysical research communications

authors： Toescu EC,Gardner JM,Petersen OH

更新日期：1993-04-30 00:00:00

abstract：:CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the antibacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, th...

journal_title：Biochemical and biophysical research communications

authors： Shin SY,Kang SW,Lee DG,Eom SH,Song WK,Kim JI

更新日期：2000-09-07 00:00:00

abstract：:A170 is an oxidative stress-inducible protein having a Zinc finger domain, two PEST sequences, and many potential phosphorylation sites for serine/threonine kinases. These structural features suggest that the phosphorylation of A170 affects its function and degradation. We have found that A170 is phosphorylated in cul...

journal_title：Biochemical and biophysical research communications

authors： Yanagawa T,Yuki K,Yoshida H,Bannai S,Ishii T

更新日期：1997-12-08 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:The results presented in this paper demonstrate that the potentiation of phagocytosis of erythrocyte (E) IgG by TNF-alpha or PMA is not due to an oxygen-dependent mechanism. In fact, the potentiation of phagocytosis occurs normally in human neutrophils 1) when the respiratory burst is inhibited by diphenyleneiodonium,...

journal_title：Biochemical and biophysical research communications

authors： Della Bianca V,Grzeskowiak M,Renzi E,Rossi F

更新日期：1993-06-30 00:00:00

abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

journal_title：Biochemical and biophysical research communications

authors： Lee PL,Halloran C,Cross AR,Beutler E

更新日期：2000-05-19 00:00:00

abstract：:Bovine cytochrome c oxidase in 0.1% dodecylmaltoside, 50 mM KCl and 10 mM Tris-HCl, pH 7.4 is monodisperse with an apparent Mr 360,000 (dimer) as estimated by filtration on Ultrogel AcA 34. In the absence of added KCl the apparent Mr is 160,000 (monomer). The dimeric enzyme has a high and a low affinity site for cytoc...

journal_title：Biochemical and biophysical research communications

authors： Nałecz KA,Bolli R,Azzi A

更新日期：1983-07-29 00:00:00

abstract：:The green color of the hemolymph of last instar larvae of the corn earworm, Heliothis zea (Boddie), is caused by the appearance of a blue chromoprotein. This protein (Mr approximately 560,000) is composed of 4 subunits (Mr approximately 150,000). It contains 8.4% lipid and has an equilibrium density of 1.26 g/ml. This...

journal_title：Biochemical and biophysical research communications

authors： Haunerland NH,Bowers WS

更新日期：1986-01-29 00:00:00

abstract：:Many calmodulin-dependent biological phenomena are regulated by calmodulin-dependent phosphorylation and dephosphorylation. In Dictyostelium discoideum, cell and pronuclear fusion during fertilization are both calmodulin-dependent biomembrane fusion events. Calmodulin-dependent phosphorylation and dephosphorylation ac...

journal_title：Biochemical and biophysical research communications

authors： Lydan MA,O'Day DH

更新日期：1993-05-14 00:00:00

abstract：:The present study has focused on the role of the 42- and 44-kDa mitogen-activated protein kinases (p42/44 MAPKs) and the 38-kDa mitogen-activated protein kinase (p38 MAPK) in the proliferation of the pancreatic beta-cell line MIN6. MIN6 beta-cell proliferation was assessed by measuring 5-bromo-2'-deoxyuridine (BrdU) i...

journal_title：Biochemical and biophysical research communications

authors： Burns CJ,Squires PE,Persaud SJ

更新日期：2000-02-16 00:00:00

abstract：:Epitopic peptides representing the C-terminal (HA1) region of cleaved hemagglutinin of influenza virus from different serotypes were synthesized. Circular dichroism and Fourier-transform infrared spectroscopic data showed that peptides HS2 and HS3 have a predominantly alpha-helical conformation in trifluoroethanol. Re...

journal_title：Biochemical and biophysical research communications

authors： Holly S,Majer Z,Tóth GK,Váradi G,Rajnavölgyi E,Laczkó I,Hollósi M

更新日期：1993-06-30 00:00:00

abstract：:The relation of expression of the LF-B1 gene with the L-type pyruvate kinase (L-PK) mRNA level in rat liver and hepatoma cells was investigated. The L-PK mRNA level in rat liver changed after partial hepatectomy, during development and on intake of a high carbohydrate diet, while the level of LF-B1 mRNA remained uncha...

journal_title：Biochemical and biophysical research communications

authors： Imai E,Noguchi T,Takenaka M,Yamada K,Matsuda T,Monaci P,Nicosia A,Tanaka T

更新日期：1991-05-15 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA) is conventionally used as a first line drug for inflammatory bowel disease (IBD). Because 5-ASA is well absorbed in the small intestine, very high dose of 5-ASA is required to deliver it to the large intestine which is a target site. Interestingly, 5-ASA is reported to be transported into...

journal_title：Biochemical and biophysical research communications

authors： Yuri T,Kono Y,Fujita T

更新日期：2020-04-09 00:00:00

abstract：:The Impact is an evolutionarily conserved gene subjected to genomic imprinting in mouse but not in human. A characteristic tandem repeat similar to those found in many other imprinted genes and an elevated expression level, both observed only for the mouse gene, are implicated in the evolution of imprinting, to which ...

journal_title：Biochemical and biophysical research communications

authors： Okamura K,Sakaki Y,Ito T

更新日期：2005-04-15 00:00:00

abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

journal_title：Biochemical and biophysical research communications

authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

更新日期：2006-06-30 00:00:00

abstract：:Malondialdehyde measurements have been the major tool for studying relationships between lipid peroxidation and tissue pathology. Recently, we presented a novel gas chromatography-mass spectrometry method for direct detection of phospholipid peroxides with picogram sensitivity based on transesterification of phospholi...

journal_title：Biochemical and biophysical research communications

authors： van Kuijk FJ,Thomas DW,Stephens RJ,Dratz EA

更新日期：1986-08-29 00:00:00

abstract：:The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid cells as well as in cell lines derived from cancer cells. We have analyzed three distinct cDNA clones isolated from an...

journal_title：Biochemical and biophysical research communications

authors： Fernández MT,Castronovo V,Rao CN,Sobel ME

更新日期：1991-02-28 00:00:00

abstract：:Little is known about the gene structure and mRNA expression of cholecystokinin type-A(CCKA) receptor in animals or in human. By screening an EMBL phage library containing partially digested Long-Evans rat DNA, we isolated 7 genomic clones covering a continuous 27 kb region over which a rat CCKA receptor gene spanned....

journal_title：Biochemical and biophysical research communications

authors： Takata Y,Takiguchi S,Funakoshi A,Kono A

更新日期：1995-08-24 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) has been widely used for determining the amounts of ornithine decarboxylase (ODC) in cells. However, we have now found that DFMO does not react with ODC-antizyme complex, indicating that the amounts of radioactive DFMO bound to the protein may not reflect the amounts of ODC in crud...

journal_title：Biochemical and biophysical research communications

authors： Kitani T,Fujisawa H

更新日期：1986-06-30 00:00:00

abstract：:Transglutaminase 2 (TGase 2) is a bifunctional enzyme that catalyzes calcium-dependent transamidation and GTP binding/hydrolysis. The transamidation activity is proposed to be associated with several neurodegenerative disorders such as Alzheimer's and Hungtinton's disease. However, the regulation mechanism by which TG...

journal_title：Biochemical and biophysical research communications

authors： Jeon JH,Cho SY,Kim CW,Shin DM,Kweon JC,Choi KH,Park SC,Kim IG

更新日期：2002-06-21 00:00:00

abstract：:Tyrosinemia type 1 (HT1) is an autosomal recessive disorder of the tyrosine metabolism in which the fumarylacetoacetate hydrolase enzyme is defective. This disease is clinically heterogeneous and a chronic and acute form is discerned. Characteristic of the chronic form is the development of cellular hepatocarcinoma. A...

journal_title：Biochemical and biophysical research communications

authors： van Dyk E,Pretorius PJ

更新日期：2005-12-16 00:00:00

abstract：:The fusion of myoblasts to myotubes requires an endogenous soluble metalloendoprotease. To determine whether this protease is released by fusing myoblasts, or stays within the cell, we examined the effects of membrane-impermeant and a membrane-permeant metalloendoprotease inhibitors. Membrane-permeant 1,10-phenanthrol...

journal_title：Biochemical and biophysical research communications

authors： Farach HA Jr,Strittmatter WJ

更新日期：1987-08-31 00:00:00

abstract：:Rubredoxin and desulforedoxin both contain an Fe(S-Cys)4 center. However, the spectroscopic properties of the center in desulforedoxin differ from rubredoxin. These differences arise from a distortion of the metal site hypothesized to result from adjacent cysteine residues in the primary sequence of desulforedoxin. Tw...

journal_title：Biochemical and biophysical research communications

authors： Yu L,Kennedy M,Czaja C,Tavares P,Moura JJ,Moura I,Rusnak F

更新日期：1997-02-24 00:00:00

abstract：:A novel 6-substituted acyclouridine derivative, 1-[(2-hydroxy-ethoxy) methyl]-6-phenylthiothymine (HEPT), has proved to be a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. HEPT inhibits HIV-1 replication in various T4 cell cultures as well as peripheral blood lymphocytes and ma...

journal_title：Biochemical and biophysical research communications

authors： Baba M,Tanaka H,De Clercq E,Pauwels R,Balzarini J,Schols D,Nakashima H,Perno CF,Walker RT,Miyasaka T

更新日期：1989-12-29 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with pleiotropic effects in normal physiology or vascular development, xenobiotic metabolism, and cancer. A previous study has reported that BRG1, a component of the SWI/SNF complex, is a coactivator for AHR and is recruited to the promoter...

journal_title：Biochemical and biophysical research communications

authors： Jin HL,Jeong KW

更新日期：2016-04-01 00:00:00

abstract：:Glioblastomas are highly invasive and aggressive primary brain tumors. Type I interferons have significant, pleiotropic anticancer activity. However, through various pathways many cancers become interferon-resistant, limiting interferon's clinical utility. In this study, we demonstrated that the proteasomal inhibitor ...

journal_title：Biochemical and biophysical research communications

authors： Wang R,Davidoff AM,Pfeffer LM

更新日期：2016-09-09 00:00:00

abstract：:Intracellular symbiotic relationships are prevalent between cnidarians, such as corals and sea anemones, and the photosynthetic dinoflagellate symbionts. However, there is little understanding about how the genes express when the symbiotic relationship is set up. To characterize genes involved in this association, the...

journal_title：Biochemical and biophysical research communications

authors： Kuo J,Chen MC,Lin CH,Fang LS

更新日期：2004-05-21 00:00:00

abstract：:TESK1 (testis-specific protein kinase 1) is a serine/threonine kinase, with a unique structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain. Northern blot analysis revealed that TESK1 mRNA is predominantly expressed in testicular germ cells. We present here evidence that express...

journal_title：Biochemical and biophysical research communications

authors： Toshima J,Koji T,Mizuno K

更新日期：1998-08-10 00:00:00