Alpha7 nicotinic acetylcholine receptor activation protects against myocardial reperfusion injury through modulation of autophagy.

abstract：:Extensive evidence suggests that reactive oxygen species are critically involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and myocardial ischemia-reperfusion injury. Consistent with this concept, administration of exogenous antioxidants has been shown to be protective against oxidative c...

journal_title：Biochemical and biophysical research communications

authors： Cao Z,Li Y

更新日期：2002-03-22 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) has been shown to negatively regulate adipogenesis. To explore to what extent PGE(2) inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells expo...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto Y,Tsuboi H,Okuno Y,Tamba S,Tsuchiya S,Tsujimoto G,Ichikawa A

更新日期：2004-09-24 00:00:00

abstract：:Previous studies have shown that high-fat diet (HFD)-induced obesity increases the acetoacetyl-CoA synthetase (AACS) gene expression in lipogenic tissue. To investigate the effect of obesity on the AACS gene in other tissues, we examined the alteration of AACS mRNA levels in HFD-fed mice. In situ hybridization reveale...

journal_title：Biochemical and biophysical research communications

authors： Yamasaki M,Hasegawa S,Imai M,Takahashi N,Fukui T

更新日期：2016-04-29 00:00:00

abstract：:CrkII is an intracellular adaptor protein involved in signal transduction by various growth factors. Activation of PDGF alpha-receptor resulted in its association with CrkII in vivo. In contrast, binding of CrkII to the PDGF beta-receptor was negligible, despite its becoming prominently phosphorylated. Bacterially exp...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto T,Yokote K,Take A,Takemoto M,Asaumi S,Hashimoto Y,Matsuda M,Saito Y,Mori S

更新日期：2000-04-02 00:00:00

abstract：:To further understand the molecular mechanism by which 1,25(OH)2-vitamin D3 [1,25(OH2D3] rapidly stimulates intestinal calcium transport (termed "transcaltachia"), the effect of the calcium channel agonist BAY K8644 was studied in vascularly perfused duodenal loops from normal, vitamin D-replete chicks. BAY K8644, 2 m...

journal_title：Biochemical and biophysical research communications

authors： de Boland AR,Nemere I,Norman AW

更新日期：1990-01-15 00:00:00

abstract：:The number of accessible SH-groups was determined in membrane vesicles prepared from Escherichia coli growing in fermentation conditions at slightly alkaline pH on glucose with or without added formate. Addition of ATP or formate to the vesicles caused a approximately 1.4-fold increase in the number of accessible SH-g...

journal_title：Biochemical and biophysical research communications

authors： Mnatsakanyan N,Poladian A,Bagramyan K,Trchounian A

更新日期：2003-08-29 00:00:00

abstract：:The synthesis of toxin protein from Ustilago maydis virus (UmV) strain P4 was studied in vitro and in vivo. The protein synthesized in vitro and in vivo has a molecular weight of approximately 30 kd whereas the native toxin has a molecular weight of about 12 kd. In the presence of protease inhibitors and glycosylation...

journal_title：Biochemical and biophysical research communications

authors： Podila GK,Bozarth RF,Flurkey WH

更新日期：1987-12-16 00:00:00

abstract：:Circular (circ)RNAs have been implicated in cancer development. However, few studies have examined the role of circRNAs in papillary thyroid cancer (PTC). In this study we found that circNUP214 was upregulated in clinical PTC specimens relative to adjacent normal tissue. In vitro analyses showed that circNUP214 knockd...

journal_title：Biochemical and biophysical research communications

authors： Li X,Tian Y,Hu Y,Yang Z,Zhang L,Luo J

更新日期：2018-12-09 00:00:00

abstract：:Parenteral immunization of transgenic mouse models of Alzheimer disease (AD) with synthetic amyloid beta-peptide (Abeta) prevented or reduced Abeta deposits and attenuated their memory and learning deficits. A clinical trial of immunization with synthetic Abeta, however, was halted due to brain inflammation, presumabl...

journal_title：Biochemical and biophysical research communications

authors： Fukuchi K,Accavitti-Loper MA,Kim HD,Tahara K,Cao Y,Lewis TL,Caughey RC,Kim H,Lalonde R

更新日期：2006-05-26 00:00:00

abstract：:The effect of HMG1 on the transcriptional block caused by left-handed Z-form in a highly negatively supercoiled DNA was examined using a supercoiled plasmid containing a (CG)10 sequence downstream of promoters. The transcription by E. coli RNA polymerase was blocked at the boundary of alternating CG sequence in the Z-...

journal_title：Biochemical and biophysical research communications

authors： Waga S,Mizuno S,Yoshida M

更新日期：1988-05-31 00:00:00

abstract：:Tetrahydrobiopterin (BH(4)) synthesis is reported to be stimulated by nerve growth factor (NGF) in PC12 cells, suggesting involvement of BH(4) in the trophic effect of NGF. We have recently reported that erythropoietin (EPO) and BH(4) enhance survival of PC12 cells. In the present study, we investigated involvement of...

journal_title：Biochemical and biophysical research communications

authors： Tanaka J,Koshimura K,Sohmiya M,Murakami Y,Kato Y

更新日期：2001-11-30 00:00:00

abstract：:Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular proc...

journal_title：Biochemical and biophysical research communications

authors： Gawron K,Jensen DA,Steplewski A,Fertala A

更新日期：2010-05-28 00:00:00

abstract：:The Rv2477c protein of Mycobacterium tuberculosis (Mtb) belongs to the ATP-binding cassette (ABC) subfamily F that contains proteins with tandem nucleotide-binding domains but lacking transmembrane domains. ABC-F subfamily proteins have been implicated in diverse cellular processes such as translation, antibiotic resi...

journal_title：Biochemical and biophysical research communications

authors： Daniel J,Abraham L,Martin A,Pablo X,Reyes S

更新日期：2018-01-01 00:00:00

abstract：:Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of drug stimuli. Here, we demonstrated that arsenic trioxide inhibited the proliferation of gallbladder carcinoma in vivo and in vitro as well as the transcription of cell cycle-related protein Cyclin D1. And,...

journal_title：Biochemical and biophysical research communications

authors： Ai Z,Lu W,Ton S,Liu H,Sou T,Shen Z,Qin X

更新日期：2007-08-31 00:00:00

abstract：:It is known that the first step in the de novo synthesis of tetrahydrobiopterin from GTP is the conversion of GTP to dihydroneopterin triphosphate. Recent evidence supports the conclusion that beyond this first step, the pterin intermediates in the pathway are all at the tetrahydro level of reduction. We have now show...

journal_title：Biochemical and biophysical research communications

authors： Milstien S,Kaufman S

更新日期：1985-05-16 00:00:00

abstract：:Measurements of the cytosolic calcium concentration in single cells of the clonal endocrine pancreatic glucagon-secreting cell line INR1 G9 revealed the existence of spontaneous calcium oscillations in 20-70% of these cells. Inhibition of these spontaneous oscillations by thapsigargin as well as the phospholipase C in...

journal_title：Biochemical and biophysical research communications

authors： Bode HP,Yule DI,Fehmann HC,Göke B,Williams JA

更新日期：1994-11-30 00:00:00

abstract：:A prolyl isomerase Pin1 deficient (Pin1-/-) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1-/- mice at reproductive age. Pin1-/- mice had lessαPLZF positive spermatogonia (undifferentiated spermatogonia) than wild type (WT). Nevertheless, the Pin1-...

journal_title：Biochemical and biophysical research communications

authors： Kurita-Suzuki A,Kamo Y,Uchida C,Tanemura K,Hara K,Uchida T

更新日期：2018-02-26 00:00:00

abstract：:Atomic force microscopy (AFM) allows to study the molecular structure of biological macromolecules with nm to A resolutions without crystallization. We show here the applicability of AFM in the quantitative analysis of the molecular mechanisms of DNA/protein interaction: (i) Protein-binding sites can be mapped over a ...

journal_title：Biochemical and biophysical research communications

authors： Nettikadan S,Tokumasu F,Takeyasu K

更新日期：1996-09-24 00:00:00

abstract：:Previous studies have suggested that 1,25(OH)2D3, the active form of vitamin D3, may increase the survival of bone-forming osteoblasts through an inhibition of apoptosis. On the other hand, vitamin D3 has also been shown to trigger apoptosis in human cancer cells, including osteosarcoma-derived cell lines. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Witasp E,Gustafsson AC,Cotgreave I,Lind M,Fadeel B

更新日期：2005-05-13 00:00:00

abstract：:We show that an autocrine system for calcitonin gene-related peptide (CGRP) exists in F9 teratocarcinoma cells. Synthesis of CGRP by F9 cells was demonstrated by measuring the peptide concentration in cells and medium and by determining specific mRNA in cells. During six days of culture, CGRP secretion did not vary si...

journal_title：Biochemical and biophysical research communications

authors： Segond N,Gerbaud P,Cressent M,Lasmoles F,Taboulet J,Jullienne A,Raynaud F,Moukhtar MS,Evain-Brion D

更新日期：1992-08-31 00:00:00

abstract：:Cytotoxic CD8(+) T cells are particularly important to the development of protective immunity against the intracellular protozoan parasite, Trypanosoma cruzi, the etiological agent of Chagas disease. We have developed a new effective strategy of genetic immunization by activating CD8(+) T cells through the ubiquitin-f...

journal_title：Biochemical and biophysical research communications

authors： Chou B,Hiromatsu K,Hisaeda H,Duan X,Imai T,Murata S,Tanaka K,Himeno K

更新日期：2010-02-12 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:An antifungal protein, AtUSP protein (At3g53990), was isolated from Arabidopsis thaliana leaves by ion and size chromatography and sequenced by N-terminal sequencing. The AtUSP gene amplified from an Arabidopsis leaf cDNA library was transformed to Escherichia coli to express the AtUSP protein. The recombinant protein...

journal_title：Biochemical and biophysical research communications

authors： Park SC,Jung YJ,Lee Y,Kim IR,Seol MA,Kim EJ,Jang MK,Lee JR

更新日期：2017-05-13 00:00:00

abstract：:Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non...

journal_title：Biochemical and biophysical research communications

authors： Marrero MT,Estévez S,Negrín G,Quintana J,López M,Pérez FJ,Triana J,León F,Estévez F

更新日期：2012-11-09 00:00:00

abstract：:The origins and developmental regulation of cerebellar oligodendrocytes are largely unknown, although some hypotheses of embryonic origins have been suggested. Neural stem cells exist in the white matter of postnatal cerebellum, but it is unclear whether these neural stem cells generate oligodendrocytes at postnatal s...

journal_title：Biochemical and biophysical research communications

authors： Naruse M,Shibasaki K,Ishizaki Y

更新日期：2015-08-07 00:00:00

abstract：:Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2...

journal_title：Biochemical and biophysical research communications

authors： Sugioka-Sugiyama R,Sugiyama T

更新日期：2011-03-18 00:00:00

abstract：:Growth and differentiation factors (GDF)-5, -6, and -7 are members of the bone morphogenetic protein (BMP) family. Previous studies suggest their importance in bone development and in tendon/ligament morphogenesis. The cells of the dental attachment apparatus, cementum, periodontal ligament, and alveolar bone proper a...

journal_title：Biochemical and biophysical research communications

authors： Morotome Y,Goseki-Sone M,Ishikawa I,Oida S

更新日期：1998-03-06 00:00:00

abstract：:Sheep thyroid cells cultured in serum-free medium were used to study the biologic activity, binding, and production of the insulin-like growth factors (IGFs). IGF-I, IGF-II, and insulin stimulated thyroid cell division. Abundant, specific IGF receptors on sheep thyroid cell membranes were identified by binding displac...

journal_title：Biochemical and biophysical research communications

authors： Bachrach LK,Eggo MC,Hintz RL,Burrow GN

更新日期：1988-08-15 00:00:00

abstract：UNLABELLED:Pervious biochemical and hemodynamic studies have highlighted the important role of εPKC in cardioprotection during ischemic preconditioning. However, little is known about the electrophysiological consequences of εPKC modulation in ischemic hearts. Membrane permeable peptide εPKC selective activator and inh...

journal_title：Biochemical and biophysical research communications

authors： Restivo M,Kozhevnikov DO,Qu YS,Yue Y,Mochly-Rosen D,El-Sherif N,Boutjdir M

更新日期：2012-09-21 00:00:00

abstract：:Type 2 diabetes mellitus is thought to be partially associated with endoplasmic reticulum (ER) stress toxicity on pancreatic beta cells and the result of decreased insulin synthesis and secretion. In this study, we showed that a well-known insulin sensitizer, metformin, directly protects against dysfunction and death ...

journal_title：Biochemical and biophysical research communications

authors： Jung TW,Lee MW,Lee YJ,Kim SM

更新日期：2012-01-06 00:00:00