PPARgamma activation abolishes LDL-induced proliferation of human aortic smooth muscle cells via SOD-mediated down-regulation of superoxide.

abstract：:The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence. To address the outstanding question of the p...

journal_title：Biochemical and biophysical research communications

authors： Chen WK,Yeap YY,Bogoyevitch MA

更新日期：2014-10-24 00:00:00

abstract：:To study polygenetically inherited human diseases like hypertension, inbred rat strains are usually the preferred models. Because many inbred generations under optimized environmental conditions may have led to the survival of "silent" disease genes, we used a cross between one wild rat and genetically hypertensive SH...

journal_title：Biochemical and biophysical research communications

authors： Klöting I,Kovács P,van den Brandt J

更新日期：2001-06-29 00:00:00

abstract：:betaC-S Lyase catalyzes the alpha,beta-elimination of L-cysteine to hydrogen sulfide, which is one of the main causes of oral malodor and is highly toxic to mammalian cells. We evaluated the capacity of six species of oral streptococci to produce hydrogen sulfide. The crude enzyme extract from Streptococcus anginosus ...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Negishi M,Amano A,Oho T,Nakano Y

更新日期：2003-01-03 00:00:00

abstract：:Enhancer of Zeste 2 (EZH2) is the key enzymatic factor in Polycomb Repressive Complex 2 (PRC2), a transcriptional repressor which contributes to oncogenesis. Recent research has revealed the key role of aberrant EZH2 hyper-activity in human gliomas. Here, we examined the role of the lesser-known PRC2-associated PHD Fi...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Ji H,Tang H,Xu Z

更新日期：2018-09-10 00:00:00

abstract：:Flo8 is a transcriptional activator essential for the inducible expression of a set of target genes such as STA1, FLO11, and FLO1 encoding an extracellular glucoamylase and two cell surface proteins, respectively. However, the molecular mechanism of Flo8-mediated transcriptional activation remains largely elusive. By ...

journal_title：Biochemical and biophysical research communications

authors： Kim HY,Lee SB,Kang HS,Oh GT,Kim T

更新日期：2014-06-27 00:00:00

abstract：:Incubation of isolated mitochondria in the presence of malonyl-CoA prevented proteolysis of the outer carnitine palmitoyltransferase by Nagarse and trypsin. Malonyl-CoA had no direct action on trypsin when present in a chromogenic assay system for proteolysis or when preincubated with the proteases in the absence of m...

journal_title：Biochemical and biophysical research communications

authors： Kashfi K,Cook GA

更新日期：1991-07-31 00:00:00

abstract：:Genotoxic agents of environmental or dietary origin may play a role in breast cancer initiation. The ability of extracts of human milk to cause mutations in S. typhimurium TA1538 and YG1019 and to induce micronuclei and DNA strand breaks in MCL-5 cells was investigated. Twenty samples from different donors were analys...

journal_title：Biochemical and biophysical research communications

authors： Martin FL,Cole KJ,Weaver G,Grover PL,Phillips DH

更新日期：1999-04-13 00:00:00

abstract：:Hyperimmunized rabbit anti-rat apolipoprotein antibodies showed reactivity to proteins in Saccharomyces cerevisiae. Antiapolipoproteins A1, B and E reacted with proteins in both a crude extract and a lipid enriched fraction. Protein reactivity was dependent on antisera dilution. Furthermore, the different antiapolipop...

journal_title：Biochemical and biophysical research communications

authors： Keesler GA,Moore S,Usher DC,Parks LW

更新日期：1991-01-31 00:00:00

abstract：:A suitable antibody for immunoaffinity chromatography is considered to efficiently bind the antigen in the adsorption step and to dissociate the bound antigen with mild changes in the environmental conditions. To develop an effective method for preparing such antibodies, murine antisera elicited by the primary and sec...

journal_title：Biochemical and biophysical research communications

authors： Enomoto A,Kamata N,Nakamura K

更新日期：1994-06-15 00:00:00

abstract：:cGMP-Phosphodiesterase 6 (PDE6) is the central effector enzyme in the phototransduction system of vertebrate photoreceptors. We have recently found that PDE6 accumulates in a detergent-resistant membrane (DRM) fraction in response to excitation of bovine rod phototransduction system. Here, we studied the molecular mec...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Seno K,Hayashi F

更新日期：2003-03-28 00:00:00

abstract：:Engineered adipose tissue could be used for the reconstruction or augmentation of soft tissues lost due to mastectomy or lumpectomy in plastic and reconstructive surgery. Preadipocytes are a feasible cell source for adipose tissue regeneration. However, the enhancement of the in vivo adipogenic conversion of preadipoc...

journal_title：Biochemical and biophysical research communications

authors： Cho SW,Kim I,Kim SH,Rhie JW,Choi CY,Kim BS

更新日期：2006-06-30 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiolog...

journal_title：Biochemical and biophysical research communications

authors： Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

更新日期：2000-02-16 00:00:00

abstract：:As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely found in many edible plants, animals and natural microorganisms, and recent studies have suggested that trehalose is an antioxidant, although its underlying molecular mech...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Zhao Q,Xiao Y,Liu X,Li Y,Zhang J,Pan J,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:We have previously described the patterns of stress kinase activation in rat kidney and heart in response to ischemia/reperfusion (Yin et al., 1997, J. Biol. Chem. 272, 19943-19950). During the course of these studies, we observed the activation of a novel kinase capable of phosphorylating c-Jun on serines 63 and 73. ...

journal_title：Biochemical and biophysical research communications

authors： De Silva H,Cioffi C,Yin T,Sandhu G,Webb RL,Whelan J

更新日期：1998-09-29 00:00:00

abstract：:The asymmetric transbilayer distribution of phospholipids in the plasma membrane and the regulation of phosphatidylserine (PS) exposure at the cell surface of animal cells are of high physiological significance. It has been shown previously that annexin V is one of the most sensitive tools with which the presence of s...

journal_title：Biochemical and biophysical research communications

authors： Geldwerth D,Helley D,de Jong K,Sabolovic' D,Sestier C,Roger J,Pons JN,Freyssinet JM,Devaux PF,Kuypers FA

更新日期：1999-04-29 00:00:00

abstract：:Streptavidin, which is one of the most widely used proteins in biotechnological application field and is active only in tetrameric form, was surface expressed on the surface of Bacillus subtilis spore. Spore coat protein of B. subtilis, CotG, was used as an anchoring motif to display streptavidin. FACS using anti-stre...

journal_title：Biochemical and biophysical research communications

authors： Kim JH,Lee CS,Kim BG

更新日期：2005-05-27 00:00:00

abstract：:The phthalate ester insensitive blue-green algae (Synechococcus lividus) were used as a food source to extend the survival of synchronously hatched brine shrimp (Artemia salina) larvae allowing measurement of a reduced toxic response to phthalate esters at late post-hatching stages of development. The maximum acute to...

journal_title：Biochemical and biophysical research communications

authors： Acey RA,Bailey S,Healy P,Jo C,Unger TF,Hudson RA

更新日期：2002-12-13 00:00:00

abstract：:Differences in insulin-like growth factor binding proteins (IGFBPs) expressed within estrogen receptor positive (ER+, MCF-7/6) and negative (ER-, MDA-MB-231) human breast cancer cells cultured in chemically defined medium were observed. In the absence of insulin, 17 beta-estradiol affects this expression in ER+ cells ...

journal_title：Biochemical and biophysical research communications

authors： Dubois V,Couissi D,Schonne E,Schneider YJ,Remacle C,Trouet A

更新日期：1993-04-15 00:00:00

abstract：:SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangol...

journal_title：Biochemical and biophysical research communications

authors： Luan J,Lu Y,Jin X,Zhang L

更新日期：2020-05-21 00:00:00

abstract：:Visual analysis of biomolecules is an integral avenue of basic and applied biological research. It has been widely carried out by tagging of nucleotides and proteins with traditional fluorophores that are limited in their application by features such as photobleaching, spectral overlaps, and operational difficulties. ...

journal_title：Biochemical and biophysical research communications

authors： Arya H,Kaul Z,Wadhwa R,Taira K,Hirano T,Kaul SC

更新日期：2005-04-22 00:00:00

abstract：:To investigate the biological function of CKII, we have identified proteins that interact with the subunits of CKII using the yeast two-hybrid system. Here we report that SAG, an antioxidant protein containing Ring-H2 finger motif, is a cellular partner associating with the beta subunit of CKII. SAG does not interact ...

journal_title：Biochemical and biophysical research communications

authors： Son MY,Park JW,Kim YS,Kang SW,Marshak DR,Park W,Bae YS

更新日期：1999-10-05 00:00:00

abstract：:The coding sequence of type II phospholipase A2 from human placenta was cloned in a bovine papilloma virus-derived eukaryotic expression vector under the control of the metallothionein promoter. Stably transfected C127 mouse fibroblast lines were obtained with this vector. These transfected cells overexpressed a funct...

journal_title：Biochemical and biophysical research communications

authors： Pernas P,Masliah J,Olivier JL,Salvat C,Rybkine T,Bereziat G

更新日期：1991-08-15 00:00:00

abstract：:The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

journal_title：Biochemical and biophysical research communications

authors： Yang H,Pu X,Wang L,Liu L,Theg SM

更新日期：2017-04-22 00:00:00

abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Chang KJ,Tamura Y,Yoshida S

更新日期：1991-02-28 00:00:00

abstract：:The effect of extracellular ATP on intracellular free Ca2+ was characterized in quin2-loaded parotid acinar cells. ATP specifically increased the intracellular Ca2+ concentration six-fold above a basal level of 180 nM. Of other purine nucleotides tested, only adenylylthiodiphosphate (ATP gamma S) had significant activ...

journal_title：Biochemical and biophysical research communications

authors： McMillian MK,Soltoff SP,Cantley LC,Talamo BR

更新日期：1987-12-16 00:00:00

abstract：:When treated with T3, P19 cells differentiate into ultrastructurally proven cardiac myocytes and express the cardiac ventricular specific marker ventricular myosin light chain 2V. This differentiation is irreversibly induced in culture during the first 48 hrs of exposure to T3. We studied the binding of P19-indigenous...

journal_title：Biochemical and biophysical research communications

authors： Rodriguez ER,Tan CD,Onwuta US,Parrillo JE

更新日期：1994-12-30 00:00:00

abstract：:Concanavalin A (ConA), a Ca(2+)/Mn(2+)-dependent and mannose/glucose-binding legume lectin, has drawn a rising attention for its remarkable anti-proliferative and anti-tumor activities to a variety of cancer cells. ConA induces programmed cell death via mitochondria-mediated, P73-Foxo1a-Bim apoptosis and BNIP3-mediate...

journal_title：Biochemical and biophysical research communications

authors： Li WW,Yu JY,Xu HL,Bao JK

更新日期：2011-10-22 00:00:00

abstract：:Sma- and MAD-related protein 3 (Smad3) plays crucial roles in the transforming growth factor-beta (TGF-beta)-mediated signaling pathway, which produce a variety of cellular responses, including cell proliferation and differentiation. In our previous study, we demonstrated that protein inhibitor of activated STATy (PIA...

journal_title：Biochemical and biophysical research communications

authors： Imoto S,Ohbayashi N,Ikeda O,Kamitani S,Muromoto R,Sekine Y,Matsuda T

更新日期：2008-05-30 00:00:00

abstract：:p21(Waf1/Cip1) is one of the key regulatory proteins in cell cycle, terminal differentiation, and apoptosis. Its promoter was shown to be transactivated by the wild-type p53 protein as well as in a p53-independent manner. In this report, we demonstrate that E1AF, an ets-related transcription factor, activates the huma...

journal_title：Biochemical and biophysical research communications

authors： Funaoka K,Shindoh M,Yoshida K,Hanzawa M,Hida K,Nishikata S,Totsuka Y,Fujinaga K

更新日期：1997-07-09 00:00:00

abstract：:The main objective of this study was to investigate the biological function of beta amyloid precursor protein (APP), in particular its nerve growth factor-like activity. We hypothesize that the extracellular domain containing the sequence RERMS, amino acids 328-332 of APP(695), represents the active site for this func...

journal_title：Biochemical and biophysical research communications

authors： Pawlik M,Otero DA,Park M,Fischer WH,Levy E,Saitoh T

更新日期：2007-04-20 00:00:00