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Genomic organization, chromosomal localization, and expression of the murine RAB3D gene.

Abstract：

:Rab proteins, members of the Ras superfamily of small GTPases, play regulatory roles in intercompartmental vesicular transport. Each step of traffic seems to require the participation of at least one distinct Rab, with the Rab3 subfamily involved in stimulated exocytosis. We report our studies on the murine rab3D gene, one of the four mammalian Rab3 isoforms. We located this gene on chromosome 13, region A(2-3). The rab3D gene consists of 5 exons spanning 10.6 kb, and the structural gene is contained in exons 2 through 5 with one canonical GTP-binding motif in each exon. Organization of the rab3D gene is identical to that of rab3A but different from other rab genes. Alternative poly-A(+) signals in the 3' untranslated region account for the identities of multiple transcripts detected by Northern blot analysis. Rab3D is expressed in all tissues studied, predominantly in heart, lung, and liver, and binding sites for multiple transcription factors are found in the TATA-less promoter region.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Adachi R,Nigam R,Tuvim MJ,DeMayo F,Dickey BF

doi

10.1006/bbrc.2000.3032

subject

Has Abstract

pub_date

2000-07-14 00:00:00

pages

877-83

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93032-8

journal_volume

273

pub_type

杂志文章

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