Abstract:
:It has been emphasized that epithelial injury is closely correlated with airway hyperresponsiveness, which is one of the important pathophysiological characteristics of bronchial asthma. Growth of epithelial cells is important in the mucosal repair processes and is believed to be regulated by growth factors produced by inflammatory and immune effector cells as well as epithelial cells themselves. We studied the role of T cell-derived lymphokines IFN gamma and IL-4 on the proliferation of human bronchial epithelial cell line BEAS-2B. IFN gamma, but not IL-4, showed a dose-dependent growth inhibitory activity in vitro. Its activity was via its specific receptors on the cells, was augmented by TNF alpha, and was independent of the activity of endogenous TGF beta and nitric oxide. These results suggested that Th-1 T cells-derived lymphokine IFN gamma might be involved in the repair processes after mucosal injury found in bronchial asthma.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kobayashi M,Niitsuma T,Hayashi T,Tanaka M,Takizawa Hdoi
10.1006/bbrc.1998.8223subject
Has Abstractpub_date
1998-03-06 00:00:00pages
126-30issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(98)98223-7journal_volume
244pub_type
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