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Era, an essential Escherichia coli small G-protein, binds to the 30S ribosomal subunit.

Abstract：

:Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein). It binds to GTP/GDP and contains a low intrinsic GTPase activity. Its function remains elusive, although it has been suggested that Era is associated with the cytoplasmic membrane, cell division, energy metabolism, and cell-cycle check point. Recently, a cold-sensitive phenotype was found to be suppressed by the overexpression of 16S rRNA methyltransferase, suggesting Era association with the ribosome. Here we demonstrate that Era specifically binds to 16S rRNA and the 30S ribosomal subunit. Both GTP and GDP, but not GMP, inhibit Era binding to ribosomal component. Involvement of Era in protein synthesis is suggested by the fact that Era depletion results in the translation defect both in vitro and in vivo.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sayed A,Matsuyama Si,Inouye M

doi

10.1006/bbrc.1999.1471

subject

Has Abstract

pub_date

1999-10-14 00:00:00

pages

51-4

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X99914717

journal_volume

264

pub_type

杂志文章

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