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Potentiation by chronic ethanol treatment of the mitochondrial permeability transition.

Abstract：

:Mitochondria isolated from rats chronically fed ethanol were more sensitive to induction of the mitochondrial permeability transition (MPT) by a variety of agents than mitochondria isolated from isocalorically matched controls. The agents utilized have been implicated in both necrotic (Ca(2+)) and apoptotic (ceramide, GD3 ganglioside, and Bax) forms of cell killing and help promote pore opening by differing mechanisms. In each case it was found that concentrations of the inducing agents which promoted little or no pore opening in mitochondria isolated from pair matched controls produced massive MTP opening in mitochondria from chronically ethanol fed rats as evidenced by swelling. In all cases induction of the MPT was prevented by the presence of cyclosporin A.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pastorino JG,Marcineviciute A,Cahill A,Hoek JB

doi

10.1006/bbrc.1999.1696

subject

Has Abstract

pub_date

1999-11-19 00:00:00

pages

405-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)91696-0

journal_volume

265

pub_type

杂志文章

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