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Increased gene expression and production of murine endothelin receptors after birth.

Abstract：

:We developed the real-time PCR quantification of endothelin-A (ET-A) and endothelin-B (ET-B) receptor genes and present their relative expression levels in various adult tissues and during development in mouse using the 2(-Delta Delta C(T)) method. ET-A and ET-B receptors were detected in all tissues examined. Gene expression of ET-A and ET-B receptors increases during the later stages of embryonic development in lung, heart, liver, kidney, and skin and reaches a maximum on the first one or two days after birth. The results, in agreement with our data on endothelin (ET) ligands, suggest that the ET system may be involved in the emergence and maintenance of functions vital after birth in these organs. These findings were corroborated through observation of the correlation between the gene expression and (poly)peptide production of the ET system in normal skin before and after parturition.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Adur J,Takizawa S,Quan J,Uchide T,Saida K

doi

10.1016/s0006-291x(03)00769-1

subject

Has Abstract

pub_date

2003-06-06 00:00:00

pages

700-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03007691

journal_volume

305

pub_type

杂志文章

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