MicroRNA let-7i induced autophagy to protect T cell from apoptosis by targeting IGF1R.

abstract：:Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrulline residues Ca(2+)-dependently. PAD V was recently found in granulocyte-differentiated HL-60 cells. To find a target of PAD V, we incubated HL-60 granulocytes with the calcium ionophore A23187 and studied deiminated proteins by immun...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara T,Nakashima K,Hirano H,Senshu T,Yamada M

更新日期：2002-01-25 00:00:00

abstract：:We have extracted and purified proteins from calcium containing urinary stones with 4 M guanidine chloride and sequenced the amino acids of the proteins. The protein of approximately 49kDa was defined as human alpha-one antitrypsin (AT, from 23rd to 42nd amino acids of NH2-terminal) by amino acid sequence analysis. Th...

journal_title：Biochemical and biophysical research communications

authors： Umekawa T,Kohri K,Amasaki N,Yamate T,Yoshida K,Yamamoto K,Suzuki Y,Sinohara H,Kurita T

更新日期：1993-06-30 00:00:00

abstract：:Hypoxia and the androgen receptor (AR) play important roles in the development and progression of prostate cancer. In this study, the combined effects of dihydrotestosterone (DHT) and hypoxia on AR-mediated transactivation were investigated. Hypoxia alone did not induce a detectable ARE-mediated response in the absenc...

journal_title：Biochemical and biophysical research communications

authors： Park C,Kim Y,Shim M,Lee Y

更新日期：2012-02-10 00:00:00

abstract：:ATP-driven, rotenone-sensitive, reverse electron transfer from succinate to acetoacetate was measured in rat liver mitochondria in the presence of cyanide. In the approach to equilibrium, the absolute ratio of the free energy change of electron transfer to that of ATP hydrolysis exceeded 1, tending towards about 1 1/4...

journal_title：Biochemical and biophysical research communications

authors： Freedman JA,Lemasters JJ

更新日期：1984-11-30 00:00:00

abstract：:Despite accumulating evidence, the role of leptin in chemokine expression is poorly understood. In this study, we evaluated the effects of leptin on CC-chemokine ligands (CCLs), CCL3, CCL4, and CCL5 gene expression in cultured murine macrophage, J774A.1 cells. Expression of all these CCLs mRNA was gradually increased ...

journal_title：Biochemical and biophysical research communications

authors： Kiguchi N,Maeda T,Kobayashi Y,Fukazawa Y,Kishioka S

更新日期：2009-07-03 00:00:00

abstract：:It is commonly assumed that plants do not possess consciousness. Since the criterion for this assumption is usually human consciousness this assumption represents a top down attitude. It is obvious that plants are not animals and using animal criteria of consciousness will lead to its rejection in plants. However usin...

journal_title：Biochemical and biophysical research communications

authors： Calvo P,Baluška F,Trewavas A

更新日期：2020-10-17 00:00:00

abstract：:Disordered circadian rhythms are associated with various psychiatric conditions and metabolic diseases. We recently established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by reduced amplitude of circadian wheel-running activity and sleep-wake cycles, sleep fragment...

journal_title：Biochemical and biophysical research communications

authors： Oishi K,Yamamoto S,Itoh N,Miyazaki K,Nemoto T,Nakakita Y,Kaneda H

更新日期：2014-07-18 00:00:00

abstract：:PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA. Up-regulation of PES1 has been documented in some human cancers, indicating that PES1 may play some crucial roles in tumorigenesis. In our previous study, it was found that silencing of PES1 resulted in decreased prolife...

journal_title：Biochemical and biophysical research communications

authors： Xie W,Qu L,Meng L,Liu C,Wu J,Shou C

更新日期：2013-02-15 00:00:00

abstract：:Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. We have found that elevations in cyclic AMP (cAMP) have long-term effects on both the beta-adrenergic receptor and adenylyl cyclase in cultured chick ventricular myocytes. Pretreatmen...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Green RD

更新日期：2003-07-18 00:00:00

abstract：:IL-17, which exerts strong pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. However, the characteristics of IL-17-producing cells, the relevance of IL-17 to clinical parameters and its function in the development and progression of colorectal carcinoma still remain to b...

journal_title：Biochemical and biophysical research communications

authors： Liu J,Duan Y,Cheng X,Chen X,Xie W,Long H,Lin Z,Zhu B

更新日期：2011-04-08 00:00:00

abstract：:Exposure of pancreatic islet B-cells to D-glucose and many other insulinotropic agents results in an increase of cytoplasmic calcium concentration, which triggers the exocytosis of secretroy granules. Previous studies have demonstrated that calcium itself, at concentrations ranging from 2 to 18 mM, is able to induce a...

journal_title：Biochemical and biophysical research communications

authors： Rasschaert J,Malaisse WJ

更新日期：1999-11-02 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:Interactions between viral and cellular proteins could explain the molecular mechanisms behind the viral life cycle of HIV-1. The envelope protein gp41 of HIV-1 specifically interacted with alpha-catenin, not with beta-catenin. This interaction was shown by in vitro protein assay and in vivo transfected cell systems. ...

journal_title：Biochemical and biophysical research communications

authors： Kim JT,Kim EM,Lee KH,Choi JE,Jhun BH,Kim JW

更新日期：2002-03-15 00:00:00

abstract：:The DiFi and HT-29 human colorectal cancer cell lines were characterized and compared with respect to binding properties of alpha adrenoceptors present on the cell surface. Both cell lines possessed alpha-1 and alpha-2 adrenoceptors of high affinity; however, DiFi cells were rich in alpha-1 adrenoceptors, whereas HT-2...

journal_title：Biochemical and biophysical research communications

authors： Agrawal DK,Wildrick DM,Boman BM

更新日期：1992-05-29 00:00:00

abstract：:In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains ATP concentrations of 3-7 mM. Very recently, ATP was prop...

journal_title：Biochemical and biophysical research communications

authors： He Y,Kang J,Song J

更新日期：2020-06-11 00:00:00

abstract：:Secreted by tumor and stromal cells, S100 proteins exert their biological functions via the interaction with surface receptors. The most described receptor is the receptor for advanced glycation end-products (RAGE), thereby participating in the S100-dependent cell migration, invasion, tumor growth, angiogenesis and me...

journal_title：Biochemical and biophysical research communications

authors： Padilla L,Dakhel S,Hernández JL

更新日期：2014-03-28 00:00:00

abstract：:Human serum albumin (HSA) serves as a natural depot of amyloid β peptide (Aβ). Improvement of Aβ binding to HSA should impede Alzheimer's disease (AD). We developed a method for quantitation of the interaction between monomeric Aβ40/42 and HSA using surface plasmon resonance spectroscopy. The dissociation constant of ...

journal_title：Biochemical and biophysical research communications

authors： Litus EA,Kazakov AS,Sokolov AS,Nemashkalova EL,Galushko EI,Dzhus UF,Marchenkov VV,Galzitskaya OV,Permyakov EA,Permyakov SE

更新日期：2019-03-05 00:00:00

abstract：:The EC(50) values for concentration-dependent stimulation of cAMP accumulation by CRF (1.3nM) and urocortin (1.0nM) were equivalent in human retinoblastoma Y79 cells. The time course and magnitude of CRF- and urocortin-induced CRF(1) receptor desensitization were similar. A significant 3-fold increase in GRK3, but not...

journal_title：Biochemical and biophysical research communications

authors： Dautzenberg FM,Wille S,Braun S,Hauger RL

更新日期：2002-11-01 00:00:00

abstract：:There is a close linear correlation between the log partition coefficient (Pa) of a series of 2'-deoxyriboside (dR), 2',3'-didehydro-3'-dideoxyriboside (ddeR), 2',3'-dideoxyriboside (ddR), 3'-fluoro-2',3'-dideoxyriboside (FddR) and 3'-azido-2',3'-dideoxyriboside (AzddR) derivatives of uracil, cytosine, thymine, guanin...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Cools M,De Clercq E

更新日期：1989-01-31 00:00:00

abstract：:Regulation of phospholipase D (PLD) activation by protein kinase C (PKC) was studied in membranes isolated from human promyelocytic leukemia HL60 cells. The activation of membrane-bound PLD by PKC partially purified from rat brain was most effectively induced with phorbol 12-myristate 13-acetate (PMA) and Ca2+ (1 micr...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Banno Y,Nakashima S,Nozawa Y

更新日期：1995-06-06 00:00:00

abstract：:Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute s...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chen M

更新日期：2018-10-20 00:00:00

abstract：:12-O-tetradecanoyl phorbol 13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol (diC8) activate protein kinase C (PKC) in transformed fetal bovine aortic endothelial GM 7373 cells. Both molecules cause a similar increase in membrane-associated PKC activity and in the phosphorylation of a PKC-specific endogenous 87-kDa subs...

journal_title：Biochemical and biophysical research communications

authors： Maier JA,Presta M,Ragnotti G

更新日期：1989-04-28 00:00:00

abstract：:Two species of scarab beetles, the Osaka beetle (Anomala osakana) and the Japanese beetle (Popillia japonica), utilize the opposite enantiomers of japonilure, (Z)-5-(1-decenyl)oxacyclopentan-2-one, as their sex pheromones. Each species produces only one of the enantiomers that functions as its own sex pheromone and as...

journal_title：Biochemical and biophysical research communications

authors： Wojtasek H,Hansson BS,Leal WS

更新日期：1998-09-18 00:00:00

abstract：:The ubiquitously expressed Calpains 1 and 2 belong to a family of calcium-dependent intracellular cysteine proteases. Both calpains are heterodimers consisting of a large subunit and a small regulatory subunit encoded by the gene Capns1. To investigate a role for the calpain small subunit in cells of the osteoblast li...

journal_title：Biochemical and biophysical research communications

authors： Kashiwagi A,Fein MJ,Shimada M

更新日期：2011-06-03 00:00:00

abstract：:The regulation of the expression of three Escherichia coli met genes, metB, which codes for cystathionine gamma-synthetase (EC 4.2.99.9), metL, which codes for aspartokinase II-homoserine dehydrogenase II (EC 2.7.2.4-EC 1.1.1.3) and metJ, which codes for the methionine regulon aporepressor, has been studied using high...

journal_title：Biochemical and biophysical research communications

authors： Shoeman R,Coleman T,Redfield B,Greene RC,Smith AA,Saint-Girons I,Brot N,Weissbach H

更新日期：1985-12-17 00:00:00

abstract：:Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a site near the amino-terminus, and quantitatively releases the larg...

journal_title：Biochemical and biophysical research communications

authors： Eide B,Gierschik P,Milligan G,Mullaney I,Unson C,Goldsmith P,Spiegel A

更新日期：1987-11-13 00:00:00

abstract：:The gene III protein (pIII) from phi Lf, a filamentous phage of Xanthomonas campestris pv.campestris, was purified by gel filtration with FPLC. The gIII coding region was amplified by PCR, which was then cloned into pUC18 and expressed in Escherichia coli. The size of both pIII, purified from phage particle and expres...

journal_title：Biochemical and biophysical research communications

authors： Liu TJ,You BY,Lin NT,Yang MT,Tseng YH

更新日期：1998-01-06 00:00:00

abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

journal_title：Biochemical and biophysical research communications

authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

更新日期：2011-08-26 00:00:00

abstract：:The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil co...

journal_title：Biochemical and biophysical research communications

authors： Hun CS,Hasegawa K,Kawabata T,Kato M,Shimokawa T,Kagawa Y

更新日期：1999-05-27 00:00:00

abstract：:The sphingolipids, sphingosine (SPH), sphingosylphosphorylcholine (SPC) and psycosine induce a rapid and transient rise in nuclear free Ca2+ concentration in a dose dependent manner. To determine whether these sphingolipids act by a IP3-dependent pathway, we tested the increase of Ca2+ in the presence of heparin, an a...

journal_title：Biochemical and biophysical research communications

authors： Catalán RE,Miguel BG,Calcerrada MC,Ruiz S,Martínez AM

更新日期：1997-09-18 00:00:00