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NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion.

Abstract：

:A new gene (GenBank Accession No. AF114264) was cloned from umbilical vein wall tissue by using RT-PCR. The gene shares high similarity to the gene encoding F-actin binding protein nexilin, so named as NELIN. A clone of 2737bp contains open reading frame of 1344bp extending from 412 to 1755. NELIN was expressed primarily in the heart and skeletal muscle among eight tested normal tissues. Immunofluorescence and immunoprecipitation demonstrated that NELIN product was associated with F-actin. Stable transfection of NELIN into HeLa cells increased the cell migration by 2.17-fold and the adhesion by 1.67-fold, respectively, compared to cells with the empty vector (P<0.05). The results support that NELIN product is an F-actin associated protein and mediates cell motility.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang W,Zhang W,Han Y,Chen J,Wang Y,Zhang Z,Hui R

doi

10.1016/j.bbrc.2005.03.082

subject

Has Abstract

pub_date

2005-05-20 00:00:00

pages

1127-31

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00565-6

journal_volume

330

pub_type

杂志文章

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