Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70.

abstract：:Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor in the bombesin receptor family that still awaits identification of its natural ligand. BRS-3 deficient mice develop a mild late-onset obesity with metabolic defects, implicating BRS-3 plays a role in feeding and metabolism. We describe here t...

journal_title：Biochemical and biophysical research communications

authors： Zhang L,Nothacker HP,Wang Z,Bohn LM,Civelli O

更新日期：2009-09-18 00:00:00

abstract：:In resting mesangial cells, angiotensin II and the calcium ionophore A23187 stimulated prostaglandin E2 (PGE2) formation. After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified res...

journal_title：Biochemical and biophysical research communications

authors： Pfeilschifter J,Mühl H

更新日期：1990-06-15 00:00:00

abstract：:Glutathione S-transferase Y-2 mRNA synthesis was induced in yeast Issatchenkia orientalis approximately 37-fold by cultivation with o-dinitrobenzene. A cDNA library complementary to poly (A)+RNA of I. orientalis grown with o-dinitrobenzene was screened by colony hybridization. Twenty positive clones were obtained from...

journal_title：Biochemical and biophysical research communications

authors： Tamaki H,Kumagai H,Tochikura T

更新日期：1990-10-30 00:00:00

abstract：:Sodium dodecyl sulfate (SDS), a representative anionic surfactant, is a commonly used reagent in studies of the cell membrane and cell wall. However, the mechanisms through which SDS affects cellular functions have not yet been fully examined. Thus, to gain further insights into the cellular functions and responses to...

journal_title：Biochemical and biophysical research communications

authors： Zhao F,Yang J,Li J,Li Z,Lin Y,Zheng S,Liang S,Han S

更新日期：2020-06-18 00:00:00

abstract：:X-linked juvenile retinoschisis (RS) is a bilateral vitreoretinal disorder with no known cure. The gene responsible for the disease was recently isolated by positional cloning methods and a spectrum of mutations has been described in families with RS pathology. In this report, we screened six sporadic cases of RS for ...

journal_title：Biochemical and biophysical research communications

authors： Hiraoka M,Trese MT,Shastry BS

更新日期：2000-02-16 00:00:00

abstract：:Parathymosin has been purified from calf liver and its primary sequence established, except for a segment containing approximately 11 amino acid residues in the central part of the polypeptide chain. Bovine parathymosin contains approximately 101 amino acid residues and shows 90% identity with rat parathymosin, with s...

journal_title：Biochemical and biophysical research communications

authors： Panneerselvam C,Clinton M,Wellner D,Horecker BL

更新日期：1988-09-15 00:00:00

abstract：:Skinned muscle fibers prepared from fetal rabbit heart (28 days of gestation) showed a marked resistance to acidic pH in the Ca(2+) regulation of force generation, compared to the fibers prepared from adult heart. SDS-PAGE and immunoblot analysis showed that the slow skeletal troponin I was predominantly expressed in ...

journal_title：Biochemical and biophysical research communications

authors： Morimoto S,Goto T

更新日期：2000-01-27 00:00:00

abstract：:Purified Human Immunodeficiency Virus (HIV) was solubilized in octylglucopyranoside. After centrifugation, the supernatant was added to lipid-detergent mixed micelles. Formation of virosomes occurred during overnight dialysis. Centrifugation on a continuous glycerol gradient showed that envelope glycoproteins (gp120 a...

journal_title：Biochemical and biophysical research communications

authors： Cornet B,Vandenbranden M,Cogniaux J,Giurgea L,Dekegel D,Ruysschaert JM

更新日期：1990-02-28 00:00:00

abstract：:Subpeptin JM4-A and subpeptin JM4-B are two novel antimicrobial peptides produced by Bacillus subtilis JM4. To identify putative genes involved in their production, degenerate PCR primers targeted to conserved motifs of nonribosomal peptide synthetases (NRPSs) were used. A resulting 1.2 kb PCR product had high sequenc...

journal_title：Biochemical and biophysical research communications

authors： Wu S,Zhong J,Huan L

更新日期：2006-06-16 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:A chemically synthesized 2,2,7-trimethylguanosine cap (TMG-cap) analogue was added to an in vitro pre-mRNA splicing system. A slight inhibition of the splicing was observed, but it was much less remarkable than that by a 7-methylguanosine cap analogue. This result does not favor a direct role of the TMG-cap structure ...

journal_title：Biochemical and biophysical research communications

authors： Tokumoto Y,Iwase R,Sekine M,Hata T,Ohshima Y

更新日期：1989-08-15 00:00:00

abstract：:Maximal stimulation of inositol 1,4,5 trisphosphate (IP3) production by epinephrine and carbachol in rat parotid cell aggregates is additive when the two agents are employed simultaneously. The additive response proceeds through both the alpha 1-adrenergic and muscarinic-cholinergic signal transduction pathways. It is...

journal_title：Biochemical and biophysical research communications

authors： Kowatch MA,Roth GS

更新日期：1991-05-15 00:00:00

abstract：:The in vitro effects of various steroid and thyroid hormones on synthesis of rat atrial natriuretic peptide (rANP) were studied using new-born rat atrial myocytes in culture. Dexamethasone, testosterone and triiodothyronine markedly stimulated both synthesis and secretion of immunoreactive (IR)-rANP with the same peak...

journal_title：Biochemical and biophysical research communications

authors： Matsubara H,Hirata Y,Yoshimi H,Takata S,Takagi Y,Iida T,Yamane Y,Umeda Y,Nishikawa M,Inada M

更新日期：1987-05-29 00:00:00

abstract：INTRODUCTION:Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. WEE1 is a cell cycle related gene that regulates the G2/M checkpoint and promotes cell cycle suspension for consequent DNA repair. To date, there are clinical studies for the evaluation of WEE1 inhibitors...

journal_title：Biochemical and biophysical research communications

authors： Barbosa RSS,Dantonio PM,Guimarães T,de Oliveira MB,Fook Alves VL,Sandes AF,Fernando RC,Colleoni GWB

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Plasma levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease and are influenced by both heredity and dietary habits. The Niemann-Pick C1 like 1 (NPC1L1) protein mediates efficient dietary cholesterol absorption and contributes to variations in human LDL-C le...

journal_title：Biochemical and biophysical research communications

authors： Yuan Q,Fu Z,Wei J,Li PS,Miao HH,Qu YX,Xu J,Qin J,Li BL,Song BL,Ma Y

更新日期：2016-10-28 00:00:00

abstract：:Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (ω-3FFA) with tamoxifen leads to improved treatment in breast cancer. In t...

journal_title：Biochemical and biophysical research communications

authors： Wu S,Guo Y,Wu Y,Zhu S,He Z,Chen YQ

更新日期：2015-04-03 00:00:00

abstract：:The risk of terrorist attacks utilizing either nuclear or radiological weapons has raised concerns about the current lack of effective radioprotectants. Here it is demonstrated that the BH4 peptide domain of the anti-apoptotic protein Bcl-xL can be delivered to cells by covalent attachment to the TAT peptide transduct...

journal_title：Biochemical and biophysical research communications

authors： McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

更新日期：2007-04-06 00:00:00

abstract：:The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family, designated Bcl-2/adenovirus E1B 19kDa interacting pro...

journal_title：Biochemical and biophysical research communications

authors： Qin W,Hu J,Guo M,Xu J,Li J,Yao G,Zhou X,Jiang H,Zhang P,Shen L,Wan D,Gu J

更新日期：2003-08-22 00:00:00

abstract：:The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking. Therefore, we investigated CYP19 mRNA expr...

journal_title：Biochemical and biophysical research communications

authors： Stoffel-Wagner B,Watzka M,Steckelbroeck S,Schwaab R,Schramm J,Bidlingmaier F,Klingmüller D

更新日期：1998-03-27 00:00:00

abstract：:Cyclosporine A (CSA) is a widely used immunosuppressant drug known to commonly cause cardio and nephrotoxicity. A study looking at the sex specificity of the cardiotoxicity of CSA revealed that sexual dimorphism existed when looking at the electrocardiographs and left ventricles of CSA-treated rats. We hypothesized th...

journal_title：Biochemical and biophysical research communications

authors： El-Bassossy HM,Eid BG

更新日期：2018-01-01 00:00:00

abstract：:The expression of mRNA for three isozymes of cytochrome P450, CYP1A1, 1A2 and 3A3, was examined in biopsied samples of colon and rectum from five healthy subjects. Using RT-PCR, it was possible to detect the three CYP mRNA species at both sites in all samples examined. The expression of each CYP mRNA was site-specific...

journal_title：Biochemical and biophysical research communications

authors： Mercurio MG,Shiff SJ,Galbraith RA,Sassa S

更新日期：1995-05-16 00:00:00

abstract：:MicroRNA-125a exhibits an antiproliferative activity and is downregulated in several types of tumors, including hepatocellular carcinoma where it targets sirtuin-7, matrix metalloproteinase-11, and c-Raf. Another target of miR-125a is Lin28, a pluripotency factor that is generally undetectable in differentiated cells ...

journal_title：Biochemical and biophysical research communications

authors： Panella M,Mosca N,Di Palo A,Potenza N,Russo A

更新日期：2018-06-07 00:00:00

abstract：:Chondrocyte- or chondrosarcoma cell line (HCS)-specific DNA fragments were obtained using differential display-PCR. Nucleotide sequences of 32 species derived from HCS cells were determined. One of the sequence tags (tag no. 24) corresponded to the nucleotide sequence of connective tissue growth factor (CTGF). Norther...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi T,Kimura Y,Tamura T,Ichikawa H,Yamaai Y,Sugimoto T,Takigawa M

更新日期：1997-05-08 00:00:00

abstract：:We previously demonstrated that the translocation of phospholipids between the mitochondrion and the endoplasmic reticulum occurs via highly specialized membrane microdomains of both organelles that are in situ closely associated. As understanding of the interactions between both organelles requires characterization o...

journal_title：Biochemical and biophysical research communications

authors： Gasnier F,Ardail D,Febvay G,Simonot C,Lerme F,Guillaud J,Louisot P,Gateau-Roesch O

更新日期：1993-09-30 00:00:00

abstract：:The conformational dependence of the interresidue interproton distances in peptides, C alpha H ... Ni + 1 H and NiH ... Ni + 1 H, have been used to identify zones of sterically allowed phi, psi space, where both distances are less than 3A and expected to yield nuclear Overhauser effects (NOEs). L-residues in left-hand...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan C,Sukumar M,Balaram P

更新日期：1987-12-31 00:00:00

abstract：:The binding site(s) in rabbit liver fructose-1,6-bisphosphatase for the active site binding ligand, fructose 6-phosphate, and the inhibitor, fructose 2,6-bisphosphate, have been investigated by using nuclear magnetic resonance spectroscopy. The distance from a nitroxide spin label to the bound ligands and the distance...

journal_title：Biochemical and biophysical research communications

authors： Liu F,Roy M,Fromm HJ

更新日期：1989-06-15 00:00:00

abstract：:Membrane-bound angiotensin-converting enzyme (ACE) expressed in Chinese hamster ovary (CHO) cells is proteolytically released in soluble form into the medium. We find that this release is stimulated up to 50-fold by phorbol-12,13-dibutyrate and also by the addition of fresh, serum-containing media. Concomitant with th...

journal_title：Biochemical and biophysical research communications

authors： Ehlers MR,Scholle RR,Riordan JF

更新日期：1995-01-17 00:00:00

abstract：:The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid cells as well as in cell lines derived from cancer cells. We have analyzed three distinct cDNA clones isolated from an...

journal_title：Biochemical and biophysical research communications

authors： Fernández MT,Castronovo V,Rao CN,Sobel ME

更新日期：1991-02-28 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) have a preventive effect against colorectal cancer. Although inhibition of cyclooxygenase-2 plays a crucial role in the suppression of tumors, precise mechanisms of their action remain to be disclosed. To identify genes involved in the growth-suppressive effect of NSAIDs, ...

journal_title：Biochemical and biophysical research communications

authors： Iizaka M,Furukawa Y,Tsunoda T,Akashi H,Ogawa M,Nakamura Y

更新日期：2002-03-29 00:00:00

abstract：:A Clostridium thermocellum gene (licB) encoding a thermoactive 1,3-1,4-beta-glucanase (lichenase) with a molecular weight of about 35,000 was localized on a 1.5-kb DNA fragment by cloning and expression in E. coli. The enzyme acts on beta-glucans with alternating beta-1,3- and beta-1,4-linkages such as barley beta-glu...

journal_title：Biochemical and biophysical research communications

authors： Schimming S,Schwarz WH,Staudenbauer WL

更新日期：1991-05-31 00:00:00