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Deuterium distribution in lactate as tracer of metabolic pathways.

Abstract：

:2H-NMR spectroscopy has been used to study the distribution of 2H atoms in brain lactate, after intraperitoneal injection of 2H2O. Information on brain metabolism was obtained from the ratio [(3-2H) lactate]/[(2-2H)-lactate] which was found very sensitive to the PO2 in the breathing air. The dependence of this ratio on the rates of metabolic pathways is an example of the possibility to use the distribution of 2H atoms in a molecule to probe metabolic flow through different pathways.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Vianello F,Scarpa M,Viglino P,Rigo A

doi

10.1006/bbrc.1997.7208

subject

Has Abstract

pub_date

1997-08-28 00:00:00

pages

650-2

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97208-9

journal_volume

237

pub_type

杂志文章

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