Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2.

Abstract:

:Breast cancer amplified sequence 2 (BCAS2) was initially identified as a gene that was overexpressed and amplified in some breast cancer cell lines. It was later found to be a component of the spliceosome. Here, we identified BCAS2 as an estrogen receptor (ER) alpha interacting protein by yeast two-hybrid screening. In addition to ER alpha, BCAS2 also interacted with ER beta, TR beta, PR, and PPAR gamma in a ligand-independent way. Transient transfection assays revealed that overexpression of BCAS2 enhanced while inhibition of BCAS2 expression attenuated the estrogen receptor-mediated transcription. BCAS2 potentiated the activation function-2 (AF-2) activity of ER alpha but had no effect on the AF-1 activity. This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function.

authors

Qi C,Zhu YT,Chang J,Yeldandi AV,Rao MS,Zhu YJ

doi

10.1016/j.bbrc.2004.12.187

subject

Has Abstract

pub_date

2005-03-11 00:00:00

pages

393-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02959-6

journal_volume

328

pub_type

杂志文章
  • Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis.

    abstract::Although leukotriene B4 (LTB4) has been reported to stimulate monocytes and neutrophils, its role on dendritic cell (DC) activity has not been examined. Here, we investigated the expression of LTB4 receptor and the effect of LTB4 on human DC chemotaxis. We analyzed LTB4 receptors, BLT1 and BLT2, by using RT-PCR. DCs e...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.07.084

    authors: Shin EH,Lee HY,Bae YS

    更新日期:2006-09-22 00:00:00

  • Stimulatory effect of endogenous tissue inhibitor of metalloproteinases-1 (TIMP-1) overexpression on type IV collagen and laminin gene expression in rat mammary carcinoma cells.

    abstract::We recently reported enhanced tumor growth and stimulation of vascular endothelial growth factor (VEGF) expression in rat mammary carcinoma cells transfected with a human tissue inhibitor of metalloproteinases-1 (hTIMP-1) cDNA (1). In the present study, we examined if the composition of the stroma was altered in the t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.8805

    authors: Yoshiji H,Buck TB,Harris SR,Ritter LM,Lindsay CK,Thorgeirsson UP

    更新日期:1998-06-29 00:00:00

  • Vascular apoptosis associated with meglumine antimoniate: In vivo investigation of a chick embryo model.

    abstract::The vasculo-toxic effect of meglumine antimoniate (MA) was confirmed in our previous investigation. The current study investigates the association of this effect with altered VEGF-A and VEGF-R2 expression. Additional mechanisms by which MA causes vascular toxicity are not clearly understood. We hypothesized that MA ma...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.09.152

    authors: Khosravi A,Sharifi I,Tavakkoli H,Keyhani AR,Afgar A,Salari Z,Mosallanejad SS,Bamorovat M,Sharifi F,Hassanzadeh S,Sadeghi B,Dabiri S,Mortazaeizdeh A,Sheikhshoaie Z,Salarkia E

    更新日期:2018-11-02 00:00:00

  • Monoclonal antibodies to low density lipoprotein used for the study of low- and very-low-density lipoproteins, in "ELISA" and immunoprecipitation technics.

    abstract::Seven monoclonal antibodies to low-density lipoprotein were studied by the ELISA for their reactivity with LDL or VLDL. Cotitration experiments showed that five of them are addressed to different antigenic epitopes. Two of the monoclonal antibodies were temperature independent whereas the others had a decreased bindin...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)90596-5

    authors: Salmon S,Goldstein S,Pastier D,Theron L,Berthelier M,Ayrault-Jarrier M,Dubarry M,Rebourcet R,Pau B

    更新日期:1984-12-14 00:00:00

  • Identification of Gliotoxin isolated from marine fungus as a new pyruvate kinase M2 inhibitor.

    abstract::Pyruvate kinase M2 (PKM2) functions as an important rate-limiting enzyme of aerobic glycolysis that is involved in tumor initiation and progression. However, there are few studies on effective PKM2 inhibitors. Gliotoxin is a marine-derived fungal secondary metabolite with multiple biological activities, including immu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.05.139

    authors: Tang W,Liu ZL,Mai XY,Qi X,Li DH,Gu QQ,Li J

    更新日期:2020-07-30 00:00:00

  • Calcium-dependent activation of human neutrophils by a synthetic ionophore.

    abstract::Synthetic block copolymers composed of polyoxyethylene and poly-oxypropylene have been demonstrated to possess ionophore activity selective for monovalent cations and to cause histamine release from mouse mast cells and human basophils. We now report calcium-dependent release of granule contents from human neutrophils...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(89)92122-0

    authors: Atkinson P,Berkow RL

    更新日期:1989-08-30 00:00:00

  • Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes.

    abstract::Imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to beta-lactam antibiotic group and to chemically unrelated ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(03)00074-3

    authors: Bornet C,Chollet R,Malléa M,Chevalier J,Davin-Regli A,Pagès JM,Bollet C

    更新日期:2003-02-21 00:00:00

  • Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP.

    abstract::HTLV-I is implicated with adult T-cell leukemia and certain other clinical disorders. The viral Tax protein is regarded as a key element in HTLV-I pathogenicity due to its ability to activate a wide variety of cellular regulatory factors. As such, Tax may likely activate also latent infection of certain other pathogen...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.04.137

    authors: Tabakin-Fix Y,Huleihel M,Aboud M

    更新日期:2004-06-11 00:00:00

  • Formation of monohydroxyeicosatetraenoic acids from arachidonic acid by cultured rabbit aortic smooth muscle cells.

    abstract::In addition to the well established cyclooxygenase pathway, cultured aortic smooth muscle cells convert arachidonic acid to several polar metabolites identified by high performance liquid chromatography and gaz chromatography-mass spectrometry. 15-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid and 5-Hyd...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)91822-3

    authors: Larrue J,Rigaud M,Razaka G,Daret D,Demond-Henri J,Bricaud H

    更新日期:1983-04-15 00:00:00

  • Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.

    abstract::Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally exp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.04.147

    authors: Huang SJ,Yang WS,Lin YW,Wang HC,Chen CC

    更新日期:2008-07-11 00:00:00

  • Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.

    abstract::Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi's sarcoma-associated herpesvirus (KSHV). This study provides evidence that proteasomal activity is required for both survival of PEL cells stably harboring the KSHV genome and viral replication of KSHV. We evaluated the cytotoxic effects of pro...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.10.107

    authors: Saji C,Higashi C,Niinaka Y,Yamada K,Noguchi K,Fujimuro M

    更新日期:2011-12-02 00:00:00

  • Single particle detection of Abeta aggregates associated with Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining of Abeta plaques and neurofibrillary tangles in brain tissue sections. We have developed an ultra-sensitive assay potential...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2007.10.085

    authors: Funke SA,Birkmann E,Henke F,Görtz P,Lange-Asschenfeldt C,Riesner D,Willbold D

    更新日期:2007-12-28 00:00:00

  • Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression.

    abstract::The stability of mRNA influences the dynamics of gene expression. The CCR4-NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and contributes to the destabilization of mRNAs. The CCR4-NOT complex plays pivotal roles in various physiological functions, including cell proliferation, ap...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.02.007

    authors: Takahashi A,Kikuguchi C,Morita M,Shimodaira T,Tokai-Nishizumi N,Yokoyama K,Ohsugi M,Suzuki T,Yamamoto T

    更新日期:2012-03-09 00:00:00

  • The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease.

    abstract::Adipose tissue is an endocrine organ that produces and secretes adipokines. The aim of this study was to identify genes predominantly expressed in human subcutaneous adipocytes. For this purpose, an algorithm was developed and DNA microarray expression profiles from 33 human tissues and cell types were used to select ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.04.030

    authors: Sjöholm K,Palming J,Lystig TC,Jennische E,Woodruff TK,Carlsson B,Carlsson LM

    更新日期:2006-06-16 00:00:00

  • Inhibition of insulin and epidermal growth factor (EGF) receptor autophosphorylation by a human polyclonal IgG.

    abstract::The immunoglobulin G of a polyclonal antiserum (pIgG) from a patient with insulin resistance and hypoglycemia was tested for its ability to inhibit insulin binding and to affect the autophosphorylation of partially-purified insulin receptors extracted from rat liver membranes. pIgG, when added 4 hr prior to insulin, i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(85)91905-9

    authors: Cordera R,Gherzi R,De Pirro R,Rossetti L,Freidenberg GR,Andraghetti G,Lauro R,Adezati L

    更新日期:1985-11-15 00:00:00

  • Intracellular localization of SNAP-23 to endosomal compartments.

    abstract::We have reexamined the intracellular localization of the ubiquitously expressed target membrane SNAP receptor (t-SNARE), SNAP-23. While SNAP-23 appears on the plasma membrane, in the cell types examined there is a significant pool associated with endosomal compartments. Immuno-staining and expression of green fluoresc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1999.0173

    authors: Chen D,Whiteheart SW

    更新日期:1999-02-16 00:00:00

  • Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter.

    abstract::The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet the needs of the body. Whole pancreas or islet transplants in patients with severe diabetes effectively restore insulin production. A lack ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/S0006-291X(02)00275-9

    authors: Lechner A,Leech CA,Abraham EJ,Nolan AL,Habener JF

    更新日期:2002-05-03 00:00:00

  • Calcium mobilization by muscarinic receptors in human astrocytoma cells: measurements with quin 2.

    abstract::Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence. Acetylcholine and methacholine were full and potent agonists, while carbachol and muscarine, were fully efficacious but 6- and 10-fold less potent than acetylcholine. The carb...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(87)80104-3

    authors: Noronha-Blob L,Richard C,U'Prichard DC

    更新日期:1987-08-31 00:00:00

  • The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.

    abstract::The 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2',3'-didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2'-deoxyadenosine (dAdo), bu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(87)91317-9

    authors: Balzarini J,Robins MJ,Zou RM,Herdewijn P,De Clercq E

    更新日期:1987-05-29 00:00:00

  • Inactivation of tyrosinase photoinduced by pterin.

    abstract::Tyrosinase catalyzes in mammals the first and rate-limiting step in the biosynthesis of the melanin, the main pigment of the skin. Pterins, heterocyclic compounds able to photoinduce oxidation of DNA and its components, accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder in wh...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.06.155

    authors: Laura Dántola M,Gojanovich AD,Thomas AH

    更新日期:2012-08-03 00:00:00

  • The effect of copper chelating drugs on liver iron mobilization in the adult rat.

    abstract::To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days. By day 6 of treatment and for the remainder of the experiment the drug-fed rats ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)90441-2

    authors: Cohen NL,Keen CL,Lönnerdal B,Hurley LS

    更新日期:1983-05-31 00:00:00

  • Hydrodynamic delivery of IL-28B (IFN-λ3) gene ameliorates lung inflammation induced by cigarette smoke exposure in mice.

    abstract::Cigarette smoke (CS) is the principal cause of pulmonary inflammatory response. IL-28 (IFN-λ) is a novel group of class II cytokines targeting the epithelial cells and IL-28 responses prominent in lungs can exert important immunomodulatory effects. We tested the hypothesis that IL-28B may modulate the lung inflammatio...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2014.04.010

    authors: Qiu C,Li Y,Zhou M,Liu J,Li M,Wu Y,Xu D,Li M

    更新日期:2014-05-09 00:00:00

  • In boar sperm capacitation L-lactate and succinate, but not pyruvate and citrate, contribute to the mitochondrial membrane potential increase as monitored via safranine O fluorescence.

    abstract::Having ascertained using JC-1 as a probe that, in distinction with the controls, during capacitation boar sperm maintains high mitochondrial membrane potential (ΔΨ), to gain some insight into the role of mitochondria in capacitation, we monitored ΔΨ generation due to externally added metabolites either in hypotonicall...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2015.04.128

    authors: Paventi G,Lessard C,Bailey JL,Passarella S

    更新日期:2015-07-03 00:00:00

  • Human receptor for activated protein kinase C1 associates with polyglutamine aggregates and modulates polyglutamine toxicity.

    abstract::Formation of SDS-insoluble protein aggregates in affected neurons is a cellular pathological feature of polyglutamine (polyQ) disease. We identified a multi-WD-domain protein, receptor for activated protein kinase C1 (RACK1), as a novel polyQ aggregate component from a Drosophila transgenic polyQ disease model. We sho...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.10.057

    authors: Lam W,Chan WM,Lo TW,Wong AKY,Wu CC,Chan HYE

    更新日期:2008-12-12 00:00:00

  • Rab7 delays intervertebral disc degeneration through the inhibition of the p38MAPK pathway.

    abstract::The objective of this study is to determine whether Rab7 could delay intervertebral disc degeneration and study the mechanism. We chose old mice to established intervertebral disc degeneration model and study the effect of Rab7 on intervertebral disc by western blotting, quantitative real-time PCR, immunohistochemistr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.04.184

    authors: Chen X,Zhang P,Ma X

    更新日期:2019-06-30 00:00:00

  • Characterization of gamma S-crystallin isoforms from lip shark (Chiloscyllium colax): evolutionary comparison between gamma S and beta/gamma crystallins.

    abstract::gamma S-Crystallin from shark eye lenses, formerly termed beta s crystallin in mammalian lenses, is structurally characterized in this study by cDNA cloning and sequencing. To facilitate sequence characterization of gamma S-crystallin possessing intermediate structural properties between beta- and gamma-crystallins, c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1997.7600

    authors: Pan FM,Chuang MH,Chiou SH

    更新日期:1997-11-07 00:00:00

  • Gamma-interferon counteracts interleukin-1 alpha stimulated expression of urokinase-type plasminogen activator in human endothelial cells in vitro.

    abstract::The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(92)92407-o

    authors: Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

    更新日期:1992-10-15 00:00:00

  • Maternal circulating syncytiotrophoblast-derived extracellular vesicles contain biologically active 5'-tRNA halves.

    abstract::The placenta releases syncytiotrophoblast-derived extracellular vesicles (STB-EV) into the maternal circulation throughout gestation. STB-EV dependent signalling is believed to contribute to the widespread maternal adaptive physiological changes seen in pregnancy. Transfer RNA (tRNA) halves have been identified in ves...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.08.015

    authors: Cooke WR,Cribbs A,Zhang W,Kandzija N,Motta-Mejia C,Dombi E,Ri R,Cerdeira AS,Redman C,Vatish M

    更新日期:2019-10-08 00:00:00

  • Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans.

    abstract::Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.08.104

    authors: Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

    更新日期:2016-09-23 00:00:00

  • Inhibition of MAP kinase promotes the recruitment of corepressor SMRT by tamoxifen-bound estrogen receptor alpha and potentiates tamoxifen action in MCF-7 cells.

    abstract::Estrogen receptor alpha (ERalpha), a ligand controlled transcription factor, plays an important role in breast cancer growth and endocrine therapy. Tamoxifen (TAM) antagonizes ERalpha activity and has been applied in breast cancer treatment. TAM-bound ERalpha associates with nuclear receptor-corepressors. Mitogen-acti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2010.04.085

    authors: Hong W,Chen L,Li J,Yao Z

    更新日期:2010-05-28 00:00:00