Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin.

abstract：:Specifier proteins are important components of the glucosinolate-myrosinase system, which mediate plant defense against herbivory and pathogen attacks. Upon tissue disruption, glucosinolates are hydrolyzed to instable aglucones by myrosinases, and then aglucones will rearrange to form defensive isothiocyanates. Specif...

journal_title：Biochemical and biophysical research communications

authors： Zhang W,Wang W,Liu Z,Xie Y,Wang H,Mu Y,Huang Y,Feng Y

更新日期：2016-09-16 00:00:00

abstract：:The exons of the lecithin:cholesterol acyltransferase (LCAT) gene in DNA samples from two of the original Swedish Fish Eye Disease patients have been amplified by polymerase chain reactions and sequenced by the dideoxy method. The two patients apparently were unrelated. In both patients a mutation in codon 10 of the f...

journal_title：Biochemical and biophysical research communications

authors： Skretting G,Prydz H

更新日期：1992-01-31 00:00:00

abstract：:Transcription factor IIA (TFIIA) is a necessary component of many RNA polymerase II transcription complexes. Assembly of the transcription complex begins when TFIIA interacts with the promoter. We have previously purified wheat germ TFIIA to homogeneity and demonstrated that it substitutes for human TFIIA in a human i...

journal_title：Biochemical and biophysical research communications

authors： Yu XB,Burke C,Zhang J,Marchitelli LJ,Davis EA,Ackerman S

更新日期：1990-04-30 00:00:00

abstract：:Defects in neurogenesis and neuronal differentiation in the fetal brain of Down syndrome (DS) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of Alzheimer's disease, those being the most common phenotype in DS. I...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Kadota M,Nishigaki R,Kazuki Y,Shirayoshi Y,Rogers MS,Gojobori T,Ikeo K,Oshimura M

更新日期：2004-02-06 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:Mammary epithelial cells derived from the entire mammary parenchyma or only end buds were isolated by collagenase digestion of mammary glands from virgin mice. Cells were cultured within collagen gels in serum-free medium containing insulin. Keratinocyte growth factor (KGF or FGF-7) and acidic fibroblast growth factor...

journal_title：Biochemical and biophysical research communications

authors： Imagawa W,Cunha GR,Young P,Nandi S

更新日期：1994-11-15 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine which is highly expressed in skeletal muscle, and which stimulates muscle protein accretion in cultured skeletal muscle fibers. Using parental C2 skeletal myoblasts, no significant effects of IL-15 on skeletal muscle differentiation were observed. To test the hypothesis that IL-15 ...

journal_title：Biochemical and biophysical research communications

authors： Quinn LS,Haugk KL,Damon SE

更新日期：1997-10-09 00:00:00

abstract：:We have designed and constructed a plasmid (pE7RZ-1) that contains a gene for a hammerhead ribozyme that specifically cleaves cottontail rabbit papillomavirus (CRPV) E7 RNA sequences in vitro. The in vitro produced transcripts of pE7RZ-1 cleave CRPV E7 target sequences in trans at 37 degrees C. Pretreatment of pE7RZ-1...

journal_title：Biochemical and biophysical research communications

authors： Wisotzkey JD,Krizenoskas A,DiAngelo S,Kreider JW

更新日期：1993-04-30 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:PP2Cgamma is a splicing factor that dephosphorylates specific substrates required for the formation of the spliceosome. In a previous study, we reported that the degradation of p21(Cip1/WAF1)was affected by PP2Cgamma, causing an accumulation of cells in S phase. Here, we demonstrate that the PP2Cgamma-induced degradat...

journal_title：Biochemical and biophysical research communications

authors： Suh EJ,Kim YJ,Kim SH

更新日期：2009-08-28 00:00:00

abstract：:Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is the only known intracellular antioxidant enzyme that can directly reduce lipid hydroperoxide in membrane. Mitochondrial and non-mitochondrial PHGPx and sperm nuclei GPx are transcribed from one gene by alternative transcription using different first exons Ia...

journal_title：Biochemical and biophysical research communications

authors： Imai H,Hirao F,Sakamoto T,Sekine K,Mizukura Y,Saito M,Kitamoto T,Hayasaka M,Hanaoka K,Nakagawa Y

更新日期：2003-05-30 00:00:00

abstract：:GroEL-like particles of Thermus aquaticus are homo-oligomeric complexes of two stacked seven member rings, sedimenting in the gradient at 20S. The apparent molecular mass of the native particles is 820,000 (+/- 30,000). The protein complex is composed with one polypeptide of M(r) 59,000. Immunoblotting results and N-t...

journal_title：Biochemical and biophysical research communications

authors： Mikulík K,Benada O

更新日期：1993-12-15 00:00:00

abstract：:Angiogenesis is a key pathogenic event in hepatic fibrogenesis, which is mediated by activated hepatic stellate cells (HSCs). TNP-470 is a known anti-angiogenic agent in cancer, and in this study, we investigated the regulatory mechanisms of TNP-470 blockage of vascular endothelial growth factor (VEGF) synthesis in ac...

journal_title：Biochemical and biophysical research communications

authors： Wang YQ,Luk JM,Chu AC,Ikeda K,Man K,Kaneda K,Fan ST

更新日期：2006-03-03 00:00:00

abstract：:Oncogenic osteomalacia (OOM), X-linked hypophosphatemia (XLH), and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum calcitriol concentrations, normal serum concentrations of calcium and...

journal_title：Biochemical and biophysical research communications

authors： Bowe AE,Finnegan R,Jan de Beur SM,Cho J,Levine MA,Kumar R,Schiavi SC

更新日期：2001-06-22 00:00:00

abstract：:FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing ...

journal_title：Biochemical and biophysical research communications

authors： Ma C,Peng C,Lu X,Ding X,Zhang S,Zou X,Zhang X

更新日期：2015-03-06 00:00:00

abstract：:Various bacteria and bacterial products induce in pure, lymphocyte-free bone marrow-derived mononuclear phagocytes (BMMø) the generation of tumor necrosis factor, nitric oxide (NO) synthase, NO and nitrite (NO2-), the flow of L-arginine to citrulline, and tumoricidal activity. The flow of L-arginine to citrulline and ...

journal_title：Biochemical and biophysical research communications

authors： Keller R,Bassetti S,Keist R,Mülsch A,Klauser S

更新日期：1992-05-15 00:00:00

abstract：:Exosomes are 50-100-nm-diameter membrane vesicles released from various types of cells. Exosomes retain proteins, mRNAs and miRNAs, which can be transported to surrounding cells. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, and is released from the cell surface to the culture medium in vitro. Recentl...

journal_title：Biochemical and biophysical research communications

authors： Sakakura H,Mii S,Hagiwara S,Kato T,Yamamoto N,Hibi H,Takahashi M,Murakumo Y

更新日期：2016-01-22 00:00:00

abstract：:The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil co...

journal_title：Biochemical and biophysical research communications

authors： Hun CS,Hasegawa K,Kawabata T,Kato M,Shimokawa T,Kagawa Y

更新日期：1999-05-27 00:00:00

abstract：:GH3/B6 pituitary cells release prolactin (PRL) in response to thyrotropin releasing hormone (TRH). Electrophysiological assays of individual GH3 cells with sharp high-resistance microelectrodes have revealed complex effects of TRH on membrane excitability consisting of a transient hyperpolarization (1), which is thoug...

journal_title：Biochemical and biophysical research communications

authors： Dufy B,MacDermott A,Barker JL

更新日期：1986-05-29 00:00:00

abstract：:We hypothesized that the mutational strand asymmetry is more strongly exerted upon the mitochondrial cytochrome b (Cytb) gene, which is distant from the origin of the light-strand replication (Ori(L)), than upon the ATPase subunit 6 (ATP6) gene, which is close to the Ori(L). To test this hypothesis, we determined the ...

journal_title：Biochemical and biophysical research communications

authors： Fuku N,Oshida Y,Takeyasu T,Guo LJ,Kurata M,Yamada Y,Sato Y,Tanaka M

更新日期：2002-02-01 00:00:00

abstract：:Using a culture system that facilitates osteogenic differentiation of bone marrow-derived human mesenchymal stem cells, we analyzed gene-expression profiles during the mineralization process by means of a cDNA microarray system consisting of 23,040 genes. We compared expression profiles of the cells at days 3, 15, and...

journal_title：Biochemical and biophysical research communications

authors： Doi M,Nagano A,Nakamura Y

更新日期：2002-01-11 00:00:00

abstract：:In rice, Hd3a, GF14 and OsFD1 proteins, forming florigen activation complex, are key components in flowering time regulation. GF14 genes in rice response to biotic and abiotic stress has also been well addressed. The role of GF14e in rice defense has been well studied. However, whether Hd3a and OsFD1 play roles in def...

journal_title：Biochemical and biophysical research communications

authors： Ke Y,Wu M,Zhang Q,Li X,Xiao J,Wang S

更新日期：2019-06-11 00:00:00

abstract：:Cells of the sponge Microciona prolifera dissociated in Ca,Mg-free sea water reaggregate upon addition of Ca, an observation classically attributed to the requirement for Ca of a species-specific aggregation factor. We now report that, unexpectedly, extracellular Ca is not required during aggregation; brief Ca pulses ...

journal_title：Biochemical and biophysical research communications

authors： Dunham P,Weissmann G

更新日期：1986-02-13 00:00:00

abstract：:We investigated the role of the 27-kDa heat shock protein (HSP27) in cardiac protection using Langendorff-perfused rat hearts. After preconditioning (a single episode of 5 min global ischemia followed by 5 min of reperfusion), HSP27 redistributed from the cytosol to the sarcomere and recovery of the contractile functi...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto K,Urushidani T,Nagao T

更新日期：2000-03-05 00:00:00

abstract：:The steady state kinetic study and some enzymic characterization of a selenium-containing scFv catalytic antibody (Se-scFv2F3) was carried out. A novel reaction formula of this abzyme-catalyzed reaction was proposed and a rate equation was gotten according to the formula. The constants in the equation were compared wi...

journal_title：Biochemical and biophysical research communications

authors： Su D,You D,Ren X,Luo G,Mu Y,Yan G,Xue Y,Shen J

更新日期：2001-07-20 00:00:00

abstract：:Although mammary epithelial cells are known to synthesize and accumulate triacylglycerol (TAG) in order to produce milk lipid in the cytosol, lipid and energy metabolism is still not fully understood. In this study, we assessed the effects of long-chain fatty acid (LCFA) on the accumulation of cytosolic TAG and uncoup...

journal_title：Biochemical and biophysical research communications

authors： Yonezawa T,Sanosaka M,Haga S,Kobayashi Y,Katoh K,Obara Y

更新日期：2008-10-17 00:00:00

abstract：:Identifying Mycobacterium tuberculosis membrane proteins involved in binding to and invasion of host cells is important in designing subunit-based anti-tuberculosis vaccines. The Rv2969c gene sequence was identified by PCR in M. tuberculosis complex strains, being transcribed in M. tuberculosis H37Rv, M. tuberculosis ...

journal_title：Biochemical and biophysical research communications

authors： Patarroyo MA,Plaza DF,Ocampo M,Curtidor H,Forero M,Rodriguez LE,Patarroyo ME

更新日期：2008-08-08 00:00:00

abstract：:RNA interference is rapidly becoming a powerful tool for gene silencing in mammalian cells. Introduction of siRNA into primary cells, however, remains one of the major difficulties of this novel technique. Using cationic lipid-based transfection reagents satisfactory transfection results are observed in cell lines, bu...

journal_title：Biochemical and biophysical research communications

authors： Lingor P,Michel U,Schöll U,Bähr M,Kügler S

更新日期：2004-03-19 00:00:00

abstract：:Although the regeneration of the adult liver depends on hepatic progenitor cells (HPCs), many uncertainties regarding hepatic regeneration in the injured liver remain. Trefoil factor family 1 (TFF1), a secretory protein predominantly expressed in the gastrointestinal tract, is responsible for mucosal restitution. Here...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Yamaguchi J,Kokuryo T,Ebata T,Yokoyama Y,Nagino M

更新日期：2018-11-17 00:00:00

abstract：:An 18-kDa lectin, with an N-terminal sequence displaying slight similarity to some lectins and fungal immunomodulatory proteins, was isolated from the mushroom Ganoderma capense (Lloyd) Teng. It exhibited more potent mitogenic activity than that of concanavalin A toward mouse splenocytes, and antiproliferative activit...

journal_title：Biochemical and biophysical research communications

authors： Ngai PH,Ng TB

更新日期：2004-02-20 00:00:00