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(+)cis-dioxolane stimulation of cytosolic calcium oscillations and phasic contractions of myometrial smooth muscle.

Abstract：

:These studies sought to determine the intracellular mechanisms underlying muscarinic receptor stimulated phasic contractions of myometrial smooth muscle. Utilizing cytosolic calcium imaging studies with Fura-2 loaded muscle strips, along with in vitro isometric contraction studies, we have demonstrated that phasic myometrial contractions stimulated in response to (+)cis-dioxolane, a muscarinic selective acetylcholine agonist, are mediated by activation of the M3 receptor subtype resulting in stimulation of the phosphatidylinositol signaling pathway and the generation of cytosolic calcium oscillations.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Phillippe M,Basa A

doi

10.1006/bbrc.1997.6163

subject

Has Abstract

pub_date

1997-02-24 00:00:00

pages

722-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96163-5

journal_volume

231

pub_type

杂志文章

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