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Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay.

Abstract：

:The maintenance of telomere length is crucial for survival of cells. Telomerase is an RNA-containing reverse transcriptase, which is responsible for elongation of shortened telomeres. Telomerase reactivation has been suggested to be involved in malignant progressions. To study on the involvement of telomerase activation in in vivo carcinogenesis, we first modified the original TRAP assay by changing the primer designs and the labeling method of PCR products to an end-labeling method. Second, we investigated the activation of telomerase in different organs after treatments of rats with various chemical carcinogens. Very early after the beginning of the treatment, telomerase activity in the liver, kidney, and lung was increased. In most cases, telomerase activation occurred in the primary or favorite target organs. The present results suggest that telomerase activation occurs promptly when animals are exposed to chemical carcinogens, which may contribute to in vivo chemical carcinogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Miura M,Karasaki Y,Abe T,Higashi K,Ikemura K,Gotoh S

doi

10.1006/bbrc.1998.8487

subject

Has Abstract

pub_date

1998-05-08 00:00:00

pages

13-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98487-X

journal_volume

246

pub_type

杂志文章

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