Quinone reduction by Rhodothermus marinus succinate:menaquinone oxidoreductase is not stimulated by the membrane potential.

abstract：:The activation of protein kinase C in human platelets by phorbol-12, 13- dibutyrate (PDBu) results in the phosphorylation of a 40,000 dalton protein. This phosphorylation is time- and concentration-dependent. Maximal phosphorylation is rapid and is not affected by indomethacin or prostacyclin. PDBu does not promote ac...

journal_title：Biochemical and biophysical research communications

authors： Lapetina EG

更新日期：1984-04-16 00:00:00

abstract：:Acetylation of lysine residues is conserved in all three kingdoms; however, its role in prokaryotes is unknown. Here we demonstrate that acetylation enables the reference bacterium Escherichia coli to withstand environmental stress. Specifically, the bacterium reaches higher cell densities and becomes more resistant t...

journal_title：Biochemical and biophysical research communications

authors： Ma Q,Wood TK

更新日期：2011-07-15 00:00:00

abstract：:Chronic subcutaneous infusion of small doses (0.1 microgram/h) of ovine corticotropin-releasing factor (oCRF) into rats for 8 days resulted in differential alteration of proopiomelanocortin (POMC) mRNA levels in the individual pituitary lobes: In the anterior lobe POMC mRNA levels, quantitated by hybridisation using a...

journal_title：Biochemical and biophysical research communications

authors： Höllt V,Haarmann I

更新日期：1984-10-30 00:00:00

abstract：:It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT(3)) receptor to cause nausea and vomiting. In general, antagonist for 5-HT(3) receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinoteca...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ishida Y,Yamada T,Shimada S

更新日期：2011-11-18 00:00:00

abstract：:Receptor activator of NF-κB (RANK) and RANK ligand (RANKL) are known to play an important role in the development and progression of breast cancer. However, the mechanisms by which stimuli regulate the expression of RANK and RANKL in breast cancer cells are largely unknown. In this study, we show that hypoxia, a commo...

journal_title：Biochemical and biophysical research communications

authors： Tang ZN,Zhang F,Tang P,Qi XW,Jiang J

更新日期：2011-05-13 00:00:00

abstract：:Human bladder carcinoma cell line EJ-1 secreted a protein of 30 kDa as a major component. This protein was purified from the serum-free conditioned medium of EJ-1. Its N-terminal amino acid sequence was identical to that of fibroblast-derived endothelial cell growth factor (f-ECGF), but there were differences in their...

journal_title：Biochemical and biophysical research communications

authors： Akaogi K,Okabe Y,Funahashi K,Yoshitake Y,Nishikawa K,Yasumitsu H,Umeda M,Miyazaki K

更新日期：1994-02-15 00:00:00

abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

journal_title：Biochemical and biophysical research communications

authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

更新日期：2011-08-26 00:00:00

abstract：:Multidrug resistance (MDR) is a unique phenomenon in cancer patients and is commonly associated with an overexpression of the human MDR gene mdr1, which encodes an energy-dependent Mr 180 kDa membrane bound protein, known as P-glycoprotein. P-glycoprotein serves as a membrane efflux to pump the drugs out of the cancer...

journal_title：Biochemical and biophysical research communications

authors： Chu TM,Lin TH,Kawinski E

更新日期：1994-08-30 00:00:00

abstract：:Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal fun...

journal_title：Biochemical and biophysical research communications

authors： Kniazeva M,Orman R,Terranova VP

更新日期：1997-05-08 00:00:00

abstract：:In fresh water planarian Dugesia japonica, two genes encoding POU-domain proteins, DjPOU1 and DjPOU2, have been identified by polymerase chain reaction (PCR). Their POU-domains are strikingly similar to class III POU-domains in mammals, frog, insects and nematode. The full-length cDNA of DjPOU1 has been cloned and seq...

journal_title：Biochemical and biophysical research communications

authors： Orii H,Agata K,Watanabe K

更新日期：1993-05-14 00:00:00

abstract：:The classified sediment with ethanol from sera of nude mice and humans showed a disturbing effect on L1210 cells in vitro and a lifesaving effect on L1210 cell-bearing mice in vivo. This factor was purified more than 2300-fold to a specific activity of approximately 1 X 10(5) U/mg by ethanol classified precipitation, ...

journal_title：Biochemical and biophysical research communications

authors： Sakagami Y,Manabe H

更新日期：1984-04-30 00:00:00

abstract：:We studied the effect of eotaxin, a novel eosinophil-active CC chemokine with high target cell specificity, on human basophils. Eotaxin induced higher levels of chemotactic response with a lower ED50 compared with RANTES in basophils; half-maximal migration occurred at a concentration of approximately 3 nM. On the oth...

journal_title：Biochemical and biophysical research communications

authors： Yamada H,Hirai K,Miyamasu M,Iikura M,Misaki Y,Shoji S,Takaishi T,Kasahara T,Morita Y,Ito K

更新日期：1997-02-13 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a widely used tumor marker, is attached by a glycosylphosphatidylinositol (GPI) anchor motif to the cell membrane. Recent study suggested that membrane-bound CEA might be cleaved by glycosylphosphatidylinositol-phospholipase D (GPI-PLD). We studied the effect of GPI-PLD on the cleavage ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto Y,Hirakawa E,Mori S,Hamada Y,Kawaguchi N,Matsuura N

更新日期：2005-07-22 00:00:00

abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

journal_title：Biochemical and biophysical research communications

authors： Upadhye S,Ananthanarayanan VS

更新日期：1995-10-13 00:00:00

abstract：:The CitA citrate transporter in Salmonella typhimurium is encoded by the citA gene and consists of 434 amino acid residues that probably include 12 membrane-spanning segments [Shimamoto. T., et al. (1991) J. Biochem. 110, 22-28]. CitA mutants with altered substrate specificities were isolated by in vitro mutagenesis u...

journal_title：Biochemical and biophysical research communications

authors： Shimamoto T,Negishi K,Tsuda M,Tsuchiya T

更新日期：1996-09-13 00:00:00

abstract：:The role of the hepatitis B virus X protein (HBx) in hepatocarcinogenesis remains controversial. To investigate the biological impact of hepatitis B virus x gene (HBx) mutation on hepatoma cells, plasmids expressing the full-length HBx or HBx deletion mutants were constructed. The biological activities in these transf...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Zhang S,Lin J,Zhang S,Feitelson MA,Gao H,Zhu M

更新日期：2008-09-05 00:00:00

abstract：:The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy used for various cellular functions and they are elevated in dens...

journal_title：Biochemical and biophysical research communications

authors： Penrose H,Heller S,Cable C,Makboul R,Chadalawada G,Chen Y,Crawford SE,Savkovic SD

更新日期：2016-01-15 00:00:00

abstract：:Research on stem-cell transplantation has indicated that the success of transplantation largely depends on synchronizing donor cells into the G0/G1 phase. In this study, we investigated the profile of embryonic stem (ES) cell synchronization and its effect on the formation of embryonic bodies (EBs) using cell culture ...

journal_title：Biochemical and biophysical research communications

authors： Zhang E,Li X,Zhang S,Chen L,Zheng X

更新日期：2005-08-12 00:00:00

abstract：:Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of...

journal_title：Biochemical and biophysical research communications

authors： Vidal O,Lindberg M,Sävendahl L,Lubahn DB,Ritzen EM,Gustafsson JA,Ohlsson C

更新日期：1999-11-19 00:00:00

abstract：:Rapid emergence of multi-drug resistance in Mycobacterium tuberculosis has necessitated the development of newer candidate drugs which can selectively inhibit the growth of the organism. Among the best targets available today, transcription machinery is, by far, the most important one and the antibiotic rifampicin bin...

journal_title：Biochemical and biophysical research communications

authors： Mukherjee R,Chatterji D

更新日期：2008-05-09 00:00:00

abstract：:The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling...

journal_title：Biochemical and biophysical research communications

authors： Kuo HP,Lee DF,Xia W,Wei Y,Hung MC

更新日期：2009-11-27 00:00:00

abstract：:The protease, cancer procoagulant, was isolated from three murine metastatic tumors and was purified to apparent homogeneity (SDS-PAGE) from Lewis lung cells by the sequence of (NH4)2SO4 precipitation, DE-53 anion-exchange chromatography, and Sephacryl 200 chromatography. The murine tumor enzyme has a molecular weight...

journal_title：Biochemical and biophysical research communications

authors： Moore WR

更新日期：1992-04-30 00:00:00

abstract：:Brush border membrane vesicles (BBMVs) prepared from midguts of Choristoneura fumiferana larvae were pretreated separately with the three CryIA delta-endotoxins from Bacillus thuringiensis subsp. kurstaki HD-1. Crossed affinity immunoelectrophoresis of the solubilized toxin-BBMV complexes, using antibodies raised agai...

journal_title：Biochemical and biophysical research communications

authors： Pang AS

更新日期：1994-03-30 00:00:00

abstract：:We have used RT-PCR with degenerate transmembrane primers to clone members of the G-coupled protein receptor family from rat hypothalamic suprachiasmatic nuclei. We report here a novel clone, UHR-1, which encodes a candidate receptor that is most similar to the neuropeptide receptor family, including the tachykinins, ...

journal_title：Biochemical and biophysical research communications

authors： Welch SK,O'Hara BF,Kilduff TS,Heller HC

更新日期：1995-04-17 00:00:00

abstract：:To obtain antiparallel and parallel dimers of alpha-human atrial natriuretic peptide (alpha-hANP), two fully protected peptides I and II having the same amino acid sequence as alpha-hANP with different protective groups at the cysteinyl residues were synthesized, the former having Acm and Npys and the latter MeBzl and...

journal_title：Biochemical and biophysical research communications

authors： Chino N,Yoshizawa-Kumagaye K,Noda Y,Watanabe TX,Kimura T,Sakakibara S

更新日期：1986-12-15 00:00:00

abstract：:Proteolipid protein, the major protein component of central nervous system (CNS) myelin, is known to contain approximately 2% by weight of covalently bound fatty acids. Recently, this protein was also found, though at a lower concentration, in the peripheral nervous system (PNS). The present study was undertaken to de...

journal_title：Biochemical and biophysical research communications

authors： Tetzloff SU,Bizzozero OA

更新日期：1993-06-30 00:00:00

abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

journal_title：Biochemical and biophysical research communications

authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

更新日期：2008-10-31 00:00:00

abstract：:The binding of leptin to hypothalamic neurons elicits inhibition of orexigenic NPY/AgRP neurons and stimulation of anorexigenic POMC/CART neurons. Projections of serotonergic neurons onto POMC neurons suggest that leptin and serotonin converge onto POMC neurons to regulate body weight. We probed the interaction of the...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Chehab FF

更新日期：2006-12-15 00:00:00

abstract：:The human kallikrein family is a group of 15 serine protease genes clustered on chromosome 19q13.4 and shares a high degree of homology. These proteolytic enzymes have diverse physiological functions in many different tissues. Growing evidence suggests that many kallikreins are differentially expressed in cancer and m...

journal_title：Biochemical and biophysical research communications

authors： Kapadia C,Ghosh MC,Grass L,Diamandis EP

更新日期：2004-10-22 00:00:00

abstract：:A monoclonal antibody (MaB) against mouse sarcoma DNA polymerase alpha was isolated from the culture medium of an IgG-secreting hybridoma. The MaB demonstrated reactivity against two murine DNA polymerase alpha preparations and a calf thymus DNA polymerase alpha. Murine sarcoma polymerase was activated in vitro by pho...

journal_title：Biochemical and biophysical research communications

authors： Sylvia VL,Norman JO,Curtin GM,Busbee DL

更新日期：1986-11-26 00:00:00