Differential inhibition of telomerase activity during induction of differentiation in hematopoietic, melanoma, and glioma cells in culture.

abstract：:Aegyptin is a mosquito salivary gland protein and potent inhibitor of platelet aggregation. Aegyptin binds to the von Willebrand factor-binding site on collagen and prevents its interaction with platelets. Because collagen also induces plasma clotting by activation of factor XII, we evaluated the effects of aegyptin o...

journal_title：Biochemical and biophysical research communications

authors： Mizurini DM,Francischetti IM,Monteiro RQ

更新日期：2013-06-28 00:00:00

abstract：:The functional importance of mitochondrial protein translation has been recently documented in the context of various cancers but not renal cell carcinoma (RCC). In lines with these efforts, our work demonstrates that mitochondrial translation inhibition by tigecycline or depletion of EF-Tu mitochondrial translation f...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Ao J,Yu D,Rao T,Ruan Y,Yao X

更新日期：2017-08-26 00:00:00

abstract：:Mammalian blastocysts are composed of two distinct cell lineages, namely the inner cell mass (ICM) and trophectoderm (TE). TE cells that give rise to the embryonic placenta are marked by an exclusive expression of the key determinant transcription factor, CDX2. Although Hippo signaling pathway is known to be responsib...

journal_title：Biochemical and biophysical research communications

authors： Kohri N,Akizawa H,Iisaka S,Bai H,Takahashi M,Kawahara M

更新日期：2020-08-06 00:00:00

abstract：:Phosphorylation of a 25 Kdalton nuclear stress protein from rat muscle was examined by two-dimensional gel electrophoresis and one-dimensional peptide mapping. These studies show that three 25 Kdalton stress proteins found in stressed rat myoblasts are actually the same protein with charge variation brought about by m...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Shuman J,Sette M,Przybyla A

更新日期：1983-12-28 00:00:00

abstract：:To develop a non-invasive and sensitive diagnostic test for cancer using peripheral blood, we evaluated gene expression profiling of blood obtained from patients with cancer of the digestive system and normal subjects. The expression profiles of blood-derived total RNA obtained from 39 cancer patients (11 colon cancer...

journal_title：Biochemical and biophysical research communications

authors： Honda M,Sakai Y,Yamashita T,Yamashita T,Sakai A,Mizukoshi E,Nakamoto Y,Tatsumi I,Miyazaki Y,Tanno H,Kaneko S,Hokuriku Liver Study Group.

更新日期：2010-09-10 00:00:00

abstract：:Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stim...

journal_title：Biochemical and biophysical research communications

authors： Kouchi H,Nakamura K,Fushimi K,Sakaguchi M,Miyazaki M,Ohe T,Namba M

更新日期：1999-11-02 00:00:00

abstract：:Renin is produced from an inactive precursor, prorenin, through endoproteolytic cleavage at paired basic amino-acid residues. Using (35S)methionine-labeled prorenin, that was synthesized with Xenopus oocyte expression system, as a substrate, we have determined the tissue distribution and the nature of prorenin-convert...

journal_title：Biochemical and biophysical research communications

authors： Nakayama K,Kim WS,Hatsuzawa K,Hashiba K,Murakami K

更新日期：1989-01-31 00:00:00

abstract：:AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, which induces cytotoxic effect to several cancer cells. Its potential activity in prostate cancer cells and the underlying signaling mechanisms have not been extensively studied. Here, we showed that AICAR p...

journal_title：Biochemical and biophysical research communications

authors： Guo F,Liu SQ,Gao XH,Zhang LY

更新日期：2016-05-27 00:00:00

abstract：:Previously, we reported the identification and characterization of a novel cancer/testis antigen gene, CAGE(4), that was expressed in various histological types of tumors, but not in normal tissues, with the exception of the testis. To date, molecular mechanisms for the expression of CAGE have never been studied. In o...

journal_title：Biochemical and biophysical research communications

authors： Cho B,Lee H,Jeong S,Bang YJ,Lee HJ,Hwang KS,Kim HY,Lee YS,Kang GH,Jeoung DI

更新日期：2003-07-18 00:00:00

abstract：:We found that both RNA and cDNA preparations derived from melanocytes contain a RT-PCR inhibitor that copurified with nucleic acids. Investigation of the candidate inhibitor melanin revealed that it potently blocks PCR at concentrations below 200 ng/ml, whereas 100 microg/ml melanin was required to inhibit reverse tra...

journal_title：Biochemical and biophysical research communications

authors： Eckhart L,Bach J,Ban J,Tschachler E

更新日期：2000-05-19 00:00:00

abstract：:The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the mini...

journal_title：Biochemical and biophysical research communications

authors： Morton AM,Cunningham AL,Diefenbach RJ

更新日期：2010-01-01 00:00:00

abstract：:The bacterioferritin-associated ferredoxin (Bfd) of Escherichia coli is a 64-residue polypeptide encoded by the bfd gene located upstream of the gene (bfr) encoding the iron-storage haemoprotein, bacterioferritin. The Bfd sequence resembles those of the approximately 60-residue domains found in NifU proteins (required...

journal_title：Biochemical and biophysical research communications

authors： Quail MA,Jordan P,Grogan JM,Butt JN,Lutz M,Thomson AJ,Andrews SC,Guest JR

更新日期：1996-12-13 00:00:00

abstract：:We have isolated the genomic clone, which contained 5'-flanking region for human terminal deoxynucleotidyltransferase (TdT) gene, by screening Charon 4A library and determined its nucleotide sequence. Two transcription initiation sites (cap sites) were localized at 81 and 106 bp upstream from the third ATG codon which...

journal_title：Biochemical and biophysical research communications

authors： Koiwai O,Morita A

更新日期：1988-07-15 00:00:00

abstract：:The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic manner. Blebbing cells transformed cell morphology...

journal_title：Biochemical and biophysical research communications

authors： Bang J,Jang M,Huh JH,Na JW,Shim M,Carlson BA,Tobe R,Tsuji PA,Gladyshev VN,Hatfield DL,Lee BJ

更新日期：2015-01-24 00:00:00

abstract：:Recently, we reported that Lumbricusin, an antimicrobial peptide isolated from earthworm Lumbricus terrestris, enhanced neuronal proliferation and ameliorated motor dysfunction and dopaminergic neurodegeneration. Accumulating evidence suggests that neurodegeneration is the primary pathological feature of acute or chro...

journal_title：Biochemical and biophysical research communications

authors： Seo M,Lee JH,Baek M,Kim MA,Ahn MY,Kim SH,Yun EY,Hwang JS

更新日期：2017-08-26 00:00:00

abstract：:Long noncoding RNA (lncRNA) LINC00319 has been reported to promote carcinogenesis of lung cancer and cutaneous squamous cell carcinoma. However, the role and mechanism of LINC00319 in ovarian cancer progression is unclear. In this study, LINC00319 expression was found to be upregulated in ovarian cancer tissues and ce...

journal_title：Biochemical and biophysical research communications

authors： Du W,Feng Z,Sun Q

更新日期：2018-12-09 00:00:00

abstract：:The chemical industry has come under increasing pressure to make chemical production more eco-friendly and independent to fossil resources. The development of industrial processes based on micro-organisms can especially help to eliminate the use or the generation of hazardous substances and can support the transition ...

journal_title：Biochemical and biophysical research communications

authors： Saibi W,Abdeljalil S,Masmoudi K,Gargouri A

更新日期：2012-09-28 00:00:00

abstract：:Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis...

journal_title：Biochemical and biophysical research communications

authors： Burton PB,Hogben CE,Joannou CL,Clark AG,Hsuan JJ,Totty NF,Sorensen C,Evans RW,Tynan MJ

更新日期：1994-12-30 00:00:00

abstract：:Insulin gene was induced into differentiated hepatic cell line. These cells released immunoreactive insulin (IRI) of which molecular weight was greater than mature insulin. The secretion of IRI was responsive to glucose concentration and inhibited by glucose metabolism antagonist, 2-deoxy glucose (2-DOG). The mRNA of ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi M,Taguchi M,Fujita T

更新日期：1997-04-17 00:00:00

abstract：:An in organello footprinting approach has been used to probe a protein-DNA interaction of a nuclear coded 25 kDa protein, previously isolated in our laboratory, that binds "in vitro" a region within the ND2 gene, located upstream of the Ori-L. Footprinting studies with the purine-modifying reagent dimethyl sulfate and...

journal_title：Biochemical and biophysical research communications

authors： Cingolani G,Capaccio L,D'Elia D,Gadaleta G

更新日期：1997-02-24 00:00:00

abstract：:With the emergence of electrospray ionization mass spectrometry (ESI-MS), mass spectrometry is no longer restricted to the study of small, stable molecules, but has become a viable technique to study large biomolecules as well as noncovalent biomolecular complexes. ESI-MS has been used to study noncovalent interaction...

journal_title：Biochemical and biophysical research communications

authors： Veenstra TD

更新日期：1999-04-02 00:00:00

abstract：:This report describes a relatively simple and reliable method for isolating adrenocortical mitochondria from rats in good, reasonably pure yield. These organelles, which heretofore have been unobtainable in isolated form from small laboratory animals, are now readily accessible. A high degree of mitochondrial purity i...

journal_title：Biochemical and biophysical research communications

authors： Solinas P,Fujioka H,Tandler B,Hoppel CL

更新日期：2012-10-12 00:00:00

abstract：:The 160 kDa alpha-mannosidase (E.C. 3.2.1.24) isolated from culture filtrate of Trichoderma reesei has wide aglycon specificity but cleaves the alpha1 --> 2 and alpha1 --> 3 mannosidic bonds with higher rate than alpha1 --> 6 bond and slowly hydrolyses yeast mannan and 1,6-alpha-mannan. The specific activity of the en...

journal_title：Biochemical and biophysical research communications

authors： Eneyskaya EV,Kulminskaya AA,Savel'ev AN,Shabalin KA,Golubev AM,Neustroev KN

更新日期：1998-04-07 00:00:00

abstract：:The change of transferrin receptors in regenerating rat liver cells after partial hepatectomy was demonstrated. The binding of 125I-labeled transferrin to the cells began to increase after 24 h of partial hepatectomy and reached about double that of the non-operated normal rat liver cells. A Scatchard analysis of bind...

journal_title：Biochemical and biophysical research communications

authors： Tei I,Makino Y,Kadofuku T,Kanamaru I,Konno K

更新日期：1984-06-15 00:00:00

abstract：:Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that ...

journal_title：Biochemical and biophysical research communications

authors： Fu J,Xu X,Kang L,Zhou L,Wang S,Lu J,Cheng L,Fan Z,Yuan B,Tian P,Zheng X,Yu C,Ye Q,Lv Z

更新日期：2014-03-07 00:00:00

abstract：:Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and en...

journal_title：Biochemical and biophysical research communications

authors： Lu S,Xu D

更新日期：2013-12-06 00:00:00

abstract：:Proliferating bovine aortic endothelial cells in culture do not express the insulin-like growth factor 1 binding protein 3 gene, in contrast to the genes encoding binding proteins 2, 4, 5, and 6. The binding protein 3 gene is activated only at cell confluency with continual transcription thereafter, for at least an ei...

journal_title：Biochemical and biophysical research communications

authors： Delafontaine P,Ku L,Anwar A,Hayzer DJ

更新日期：1996-05-15 00:00:00

abstract：:Liposomes prepared from lecithin:cholesterol:p-aminophenyl-alpha-mannoside (7:2:1, v/v/v) were efficiently incorporated into the mouse brain across the blood brain barrier. Furthermore, liposomes injected intraperitoneally were exclusively distributed into lysosome rich fraction and also taken up by glial cells. These...

journal_title：Biochemical and biophysical research communications

authors： Umezawa F,Eto Y

更新日期：1988-06-30 00:00:00

abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

journal_title：Biochemical and biophysical research communications

authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

更新日期：1992-10-15 00:00:00

abstract：:cDNAs were molecularly cloned for proteins specifically expressed in embryo as well as in a chemically induced rat pancreatic B cell tumor in which virally related oncogenes such as v-myc, v-src, v-yes, v-mos and v-kis were previously demonstrated not to be expressed. A plasmid cDNA library consisting of 48,000 indepe...

journal_title：Biochemical and biophysical research communications

authors： Soma G,Kitahara N,Andoh T

更新日期：1984-10-15 00:00:00