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Structural analysis of the flagellar capping protein FliD from Helicobacter pylori.

Abstract：

:Helicobacter pylori is a pathogenic flagellated bacterium that infects the gastroduodenal mucosa and causes peptic ulcers in humans. FliD caps the distal end of the flagellar filament and is essential in filament growth. Moreover, FliD has been studied to diagnose and prevent H. pylori infection. Here, we report structure-based molecular studies of H. pylori FliD (hpFliD). A crystal structure of hpFliD at 2.6 Å resolution presents a four-domain (D2-D5) structure, where the D3 domain forms a central platform surrounded by the other three domains (D2, D4, and D5). hpFliD domains D2 and D3 structurally resemble those of FliD orthologs, whereas the D4 and D5 domains are exclusive to hpFliD. Moreover, our ELISA analysis using anti-H. pylori antibodies demonstrated that the hpFliD-specific D4 and D5 domains are highly antigenic compared to the D2 and D3 domains. Collectively, our structural and serological analyses underscore the structural role of hpFliD domains and provide a molecular basis for vaccine and diagnosis development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cho SY,Song WS,Oh HB,Kim HU,Jung HS,Yoon SI

doi

10.1016/j.bbrc.2019.04.065

subject

Has Abstract

pub_date

2019-06-18 00:00:00

pages

98-104

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30693-X

journal_volume

514

pub_type

杂志文章

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