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Light-activated release of nitric oxide from vascular smooth muscle of normotensive and hypertensive rats.

Abstract：

:A porphyrinic sensor was used to monitor nitric oxide release from vascular smooth muscle in response to exposure to ultraviolet light. Aortic rings exposed to UV light relaxed with a time course that parallels this observed NO release. With repeated UV light treatments, the magnitude of the relaxations diminished, suggesting that a store of NO was being exhausted. Photorelaxation in response to UV light was studied in aortic ring from two types of hypertensive rats, genetic (SHRSP) and nitroarginine-induced. These aortic rings showed greater photorelaxation and evidenced less tolerance than did aortic rings from control normotensive rats. Since NO synthase activity is depressed in both types of hypertension, it appears, paradoxically, that the UV light-releasable store of NO is augmented when NO synthase activity is depressed.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kubaszewski E,Peters A,McClain S,Bohr D,Malinski T

doi

10.1006/bbrc.1994.1436

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

213-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71436-7

journal_volume

200

pub_type

杂志文章

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