Decreased expression of glutaredoxin 1 is required for transforming growth factor-beta1-mediated epithelial-mesenchymal transition of EpRas mammary epithelial cells.

abstract：:It has been emphasized that epithelial injury is closely correlated with airway hyperresponsiveness, which is one of the important pathophysiological characteristics of bronchial asthma. Growth of epithelial cells is important in the mucosal repair processes and is believed to be regulated by growth factors produced b...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi M,Niitsuma T,Hayashi T,Tanaka M,Takizawa H

更新日期：1998-03-06 00:00:00

abstract：:Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study ...

journal_title：Biochemical and biophysical research communications

authors： Efrat M,Aviram M

更新日期：2008-11-07 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：:To develop antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine (T3) binding protein (M.W. 55,000), rabbits were immunized with formalin-fixed GH3 cells or highly purified plasma membranes from these cells. Antibodies were screened by immunoprecipitation using detergent solubilized N-bromoacetyl-[125I]T3-...

journal_title：Biochemical and biophysical research communications

authors： Hasumura S,Rossi B,Alderson R,Pastan I,Cheng S

更新日期：1984-11-14 00:00:00

abstract：:VEGF-induced vascular barrier disruptions, formation of fenestrae and vesiculo-vacuolar organelles (VVOs), are involved in enhancing vascular permeability in metastatic and edematous diseases. Here, we analyzed vascular permeability enhanced by VEGFs with different receptor selectivity using biological and ultrastruct...

journal_title：Biochemical and biophysical research communications

authors： Matsunaga Y,Yamazaki Y,Suzuki H,Morita T

更新日期：2009-02-20 00:00:00

abstract：:Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote multiple tumorigenic processes, as well as to correlate with worse prognosis in many different tumor types. However, studies of Axl expression and function in osteosarcoma have rarely been reported. In this study, we report...

journal_title：Biochemical and biophysical research communications

authors： Han J,Tian R,Yong B,Luo C,Tan P,Shen J,Peng T

更新日期：2013-06-07 00:00:00

abstract：:In this study, we established an in vitro hypoxic system driven by a self-regulated chemical reaction that proved effective for cell culture. The hypoxic device was modified from a 1.5 L polypropylene preservation box normally employed for food storage. Pyrogallic acid, sodium hydroxide, and sodium carbonate were diss...

journal_title：Biochemical and biophysical research communications

authors： Han N,Wang Z,Wang G,Yu J,Chen C,Huang H,Xu R

更新日期：2018-06-07 00:00:00

abstract：:Jasmonates are plant lipid-derived oxylipins that act as key signaling compounds in plant immunity, germination, and development. Although some physiological activities of natural jasmonates in mammalian cells have been investigated, their anti-inflammatory actions in mammalian cells remain unclear. Here, we investiga...

journal_title：Biochemical and biophysical research communications

authors： Taki-Nakano N,Kotera J,Ohta H

更新日期：2016-05-13 00:00:00

abstract：:CAP is a multifunctional protein; the N-terminal region binds adenylyl cyclase and controls its response to Ras while the C-terminal region is involved in cytoskeletal regulation. In between the two regions, CAP possesses two proline-rich segments, P1 and P2, resembling a consensus sequence for binding SH3 domains. We...

journal_title：Biochemical and biophysical research communications

authors： Yanagihara C,Shinkai M,Kariya K,Yamawaki-Kataoka Y,Hu CD,Masuda T,Kataoka T

更新日期：1997-03-17 00:00:00

abstract：:The presence of at least two distinct Mg2+- or Mn2+-dependent, Ca2+-independent endonuclease activities was shown in the myeloid leukemia cell line P39. One of them was recovered from nuclear extracts and the other from a cytoplasmic fraction. The molecular size of the former was 30 kDa in both gel filtration and acti...

journal_title：Biochemical and biophysical research communications

authors： Kawabata H,Anzai N,Masutani H,Hirama T,Hishita T,Dodo M,Masuda T,Yoshida Y,Okuma M

更新日期：1997-04-07 00:00:00

abstract：:Hairpin antisense oligodeoxyribonucleotides containing 2'-methoxynucleosides were more active in the micromolar concentration range than linear and DNA hairpin phosphorothioate oligonucleotides with the same sequence. Furthermore, the abilities of hairpin antisense and random hairpin phosphorothioate oligonucleotides ...

journal_title：Biochemical and biophysical research communications

authors： Kuwasaki T,Hosono K,Takai K,Ushijima K,Nakashima H,Saito T,Yamamoto N,Takaku H

更新日期：1996-11-12 00:00:00

abstract：:The soil fungus Mucor genevensis was shown to convert exogenous arachidonic acid to the oxylipin 3-hydroxy-5Z,8Z-tetradecadienoic acid (3-HTDE) as determined by gas chromatography/mass spectrometry. This metabolite was only found in the aqueous supernatant together with free linoleic acid, but not in the final fungal ...

journal_title：Biochemical and biophysical research communications

authors： Pohl CH,Botha A,Kock JL,Coetzee DJ,Botes PJ,Schewe T,Nigam S

更新日期：1998-12-30 00:00:00

abstract：:Heat shock proteins are detectable in human atherosclerotic plaques, especially in endothelial cells. In this report we show by immunofluorescence that incubation "in vitro" with OxLDL is a stress capable of inducing the expression of heat shock protein 70 in both the EAhy-926 cell line and human umbilical vein endoth...

journal_title：Biochemical and biophysical research communications

authors： Zhu W,Roma P,Pellegatta F,Catapano AL

更新日期：1994-04-15 00:00:00

abstract：:FIP-3 (NEMO/IKKgamma) is an essential modulator of the activity of NF-kappaB by mechanisms that include alterations in the phosphorylation, ubiquination, and degradation of IkappaBalpha. The multiple protein-protein interactions of FIP-3 (NEMO/IKKgamma) in a high molecular weight IKK complex indicated that this protei...

journal_title：Biochemical and biophysical research communications

authors： Tarassishin L,Horwitz MS

更新日期：2001-07-13 00:00:00

abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

journal_title：Biochemical and biophysical research communications

authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

更新日期：1986-10-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors have been demonstrated to regulate myeloid cell differentiation. In the present study the effects of the HDAC inhibitor trichostatin A (TSA) on the tetraspanin cell surface antigen CD9 were determined in primary murine macrophages. TSA inhibited CD9 protein and message expression ...

journal_title：Biochemical and biophysical research communications

authors： Wang XQ,Alfaro ML,Evans GF,Zuckerman SH

更新日期：2002-06-14 00:00:00

abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

journal_title：Biochemical and biophysical research communications

authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

更新日期：1990-11-15 00:00:00

abstract：:A novel DNA sequence belonging to a new genotype of TT virus (TTV) was detected by long-distance PCR in the serum of a chronically HCV-infected patient. The isolate was designated KAV according to the patient's initials. Extending the sequence to full length revealed a 3705-nt viral genome, which is about 100 nucleoti...

journal_title：Biochemical and biophysical research communications

authors： Heller F,Zachoval R,Koelzer A,Nitschko H,Froesner GG

更新日期：2001-12-21 00:00:00

abstract：:Adenovirus DNA synthesis carried out in vitro was inhibited by the aphidicolin. However, 30% of the DNA synthesis was resistant to aphidicolin even at a concentration of 200 micrograms/ml. When the distribution patterns of the radioactivity of the products synthesized in the presence of 50 micrograms/ml of the drug wa...

journal_title：Biochemical and biophysical research communications

authors： Ariga H

更新日期：1983-05-31 00:00:00

abstract：:WAF1 inhibits cyclin-cyclin dependent kinase complexes, causing arrest in the cell cycle. We report that interleukin-1 (IL-1) regulates the levels of WAF1 protein and mRNA in human fibroblasts. Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory t...

journal_title：Biochemical and biophysical research communications

authors： Osawa Y,Hachiya M,Koeffler HP,Suzuki G,Akashi M

更新日期：1995-11-13 00:00:00

abstract：:We investigated the role of tyrosine phosphorylation of FAK in the stretch-induced MAPKs (extracellular signal-regulated kinase (ERK), p38MAPK) activation in mutant FAK-transfected fibroblasts. In response to uniaxial cyclic stretch (1 Hz, 120% in length), the levels of tyrosine phosphorylation of the Tyr-397 and Tyr-...

journal_title：Biochemical and biophysical research communications

authors： Wang JG,Miyazu M,Matsushita E,Sokabe M,Naruse K

更新日期：2001-10-26 00:00:00

abstract：:Dinoflagellates are protists with permanently condensed chromosomes that lack histones and whose nuclear membrane remains intact during mitosis. These unusual nuclear characters have suggested that the typical cell cycle regulators might be slightly different than those in more typical eukaryotes. To test this, a cycl...

journal_title：Biochemical and biophysical research communications

authors： Bertomeu T,Morse D

更新日期：2004-10-29 00:00:00

abstract：:Comprehensive knowledge on the murine CT26 colon carcinoma line is a classic model used in the pharmacodynamic experiments involving IDO-1 inhibitors, immune-related checkpoint antibodies and immune related mechanisms. In this study, we determined the impact of different subcutaneous inoculation locations on tumor gro...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Yang Y,Xie J,Pan X,Yang X,Du Z,Hao E

更新日期：2019-04-30 00:00:00

abstract：:Lateral diffusion coefficients (D) of two surface differentiation antigens (sIgM and Bp35) were determined on interferon-sensitive (-IFs) or resistant (-IFr) Daudi cells by fluorescence photobleaching, using monospecific FITC-anti-IgM or PE-anti-Leu 16 probes. For untreated Daudi -IFs, mean (D) were 5.8 and 5.3 (x10(-...

journal_title：Biochemical and biophysical research communications

authors： Balint E,Aszalos A,Grimley PM

更新日期：1988-12-15 00:00:00

abstract：:The effect of opioids on NO production by LPS-stimulated murine macrophages J774 has been investigated. Morphine (mu and k opioid receptor agonist), DAGO (selective mu receptor agonist) and U50-488H (selective k receptor agonist), added (10(-10)-10(-6) M) to the cells 0.5 h before activation with LPS, significantly in...

journal_title：Biochemical and biophysical research communications

authors： Iuvone T,Capasso A,D'Acquisto F,Carnuccio R

更新日期：1995-07-26 00:00:00

abstract：:Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that...

journal_title：Biochemical and biophysical research communications

authors： Whitson RH,Tsark W,Huang TH,Itakura K

更新日期：2003-12-26 00:00:00

abstract：:Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circad...

journal_title：Biochemical and biophysical research communications

authors： Oiwa A,Kakizawa T,Miyamoto T,Yamashita K,Jiang W,Takeda T,Suzuki S,Hashizume K

更新日期：2007-02-23 00:00:00

abstract：:Phosphofructokinase of rabbit muscle, which is specific for nucleoside triphosphates such as ATP, dissociated and gained the capability to utilize pyrophosphate as phosphoryl donor following incubation with UDP-glucose. The pyrophosphate- and ATP-linked activities of UDP-glucose-treated muscle phosphofructokinase were...

journal_title：Biochemical and biophysical research communications

authors： Wong JH,Balogh A,Buchanan BB

更新日期：1984-06-29 00:00:00

abstract：:HspA1A, a seventy-kilodalton heat shock protein, binds to specific anionic lipids and this interaction regulates important physiological phenomena like apoptosis, tumor growth, and lysosomal rescue. However, whether HspA1A binds to phosphoinositides has yet to be established and quantified. Therefore, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： McCallister C,Kdeiss B,Oliverio R,Nikolaidis N

更新日期：2016-03-25 00:00:00

abstract：:The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro kinase assay demonstrated that it is a substrate for MAP kinase. Phosphorylation of endogenous HABP1 was also observed following treatment of J774 cells with PMA. HABP1 was coimmunoprecipitated with activated ERK, confirmi...

journal_title：Biochemical and biophysical research communications

authors： Majumdar M,Meenakshi J,Goswami SK,Datta K

更新日期：2002-03-08 00:00:00