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Kinetic analysis of the binding of guanine nucleotide to bovine brain smg p25A.

Abstract：

:Bovine brain smg p25A, a guanine nucleotide-binding protein with a Mr of about 25,000, bound specifically GTP, guanosine 5'-(3-O-thio)triphosphate (GTP gamma S) and GDP. The initial velocities of the binding of GTP gamma S to GDP-bound smg p25A and the dissociation of GDP from this protein increased by decreasing Mg2+ concentrations or increasing NaCl concentrations. The initial velocity of the binding of GTP gamma S to GDP-free smg p25A was not affected by changing Mg2+ concentrations. These results indicate that the dissociation of GDP from smg p25A limits the binding of GTP to this protein, and suggest that there is a protein stimulating the dissociation of GDP from smg p25A and thereby stimulating the binding of GTP to this protein in mammalian tissues. In fact, the protein stimulating the dissociation of GDP, but not of GTP gamma S, from smg p25A was detected in bovine brain cytosol.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shoji I,Kikuchi A,Kuroda S,Takai Y

doi

10.1016/0006-291x(89)91992-x

subject

Has Abstract

pub_date

1989-07-14 00:00:00

pages

273-81

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91992-X

journal_volume

162

pub_type

杂志文章

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