Sck interacts with KDR and Flt-1 via its SH2 domain.

abstract：:In the present study, we investigated if Cl(-) regulates the proliferation of the MC3T3-E1 osteoblastic cells. The proliferation of MC3T3-E1 osteoblastic cells was diminished by lowering the extracellular Cl(-) concentration ([Cl(-)](o)) in the culture medium. The lowered in [Cl(-)](o) increased the periods of the G(0...

journal_title：Biochemical and biophysical research communications

authors： Maki M,Miyazaki H,Nakajima K,Yamane J,Niisato N,Morihara T,Kubo T,Marunaka Y

更新日期：2007-10-05 00:00:00

abstract：:Mammalian X and Y chromosomes evolved from a pair of autosomes. Although most ancestral genes have been lost from the Y chromosome, a small number of ancestral X-Y gene pairs are still present on the sex chromosomes. The KDM5C and KDM5D genes, which encode H3K4 histone demethylases, are a surviving ancestral gene pair...

journal_title：Biochemical and biophysical research communications

authors： Kosugi M,Otani M,Kikkawa Y,Itakura Y,Sakai K,Ito T,Toyoda M,Sekita Y,Kimura T

更新日期：2020-02-17 00:00:00

abstract：:The surface receptor CUB domain-containing protein 1 (CDCP1) is highly expressed in several adenocarcinomas and speculated to participate in anchorage-independent cell survival and cell motility. Tyrosine kinase phosphorylation seems to be crucial for intracellular signaling of CDCP1. Lapatinib, a tyrosine kinase inhi...

journal_title：Biochemical and biophysical research communications

authors： Seidel J,Kunc K,Possinger K,Jehn C,Lüftner D

更新日期：2011-10-14 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:The Z-DNA binding domain of human ADAR1 (Zα(ADAR1)) preferentially binds Z-DNA rather than B-DNA with high binding affinity. Here, we have carried out chemical shift perturbation and backbone dynamics studies of Zα(ADAR1) in the free form and in complex with three DNA duplexes, d(CGCGCG)(2), d(CACGTG)(2), and d(CGTACG...

journal_title：Biochemical and biophysical research communications

authors： Lee AR,Kim HE,Lee YM,Jeong M,Choi KH,Park JW,Choi YG,Ahn HC,Choi BS,Lee JH

更新日期：2012-11-09 00:00:00

abstract：:A cDNA coding for rat IL-5 was obtained by RT-PCR from total spleen RNA. With the exception of a single a.a. replacement at position 85 (L-P), it is identical to the published sequence obtained by retroviral gene transfer. This cDNA was used to express biologically active recombinant IL-5 in E. coli and in insect cell...

journal_title：Biochemical and biophysical research communications

authors： Pierrot C,Cocude C,Cêtre C,Godin C,Lafitte S,Capron M,Khalife J

更新日期：1998-12-30 00:00:00

abstract：:Gastrin is a peptide hormone important in acid regulation, growth of enterochromaffin cells of the oxyntic mucosa, and smooth muscle contractility. We isolated a genomic clone of gastrin from a SV-129 murine genomic library. The murine gastrin gene contains an open reading frame of 101 amino acids. The deduced amino a...

journal_title：Biochemical and biophysical research communications

authors： Koh TJ,Wang TC

更新日期：1995-11-02 00:00:00

abstract：:Strategy to differentiate stem cells into insulin producing cells (IPCs) in vitro has been a promising one to get cell source of β-cell replacement therapy for diabetes. It has been suggested that islets and neurons share features and nestin-positive cells could differentiate into IPCs. We have recently developed a th...

journal_title：Biochemical and biophysical research communications

authors： Hur J,Yang JM,Choi JI,Yun JY,Jang JH,Kim J,Kim JY,Oh IY,Yoon CH,Cho HJ,Park YB,Kim HS

更新日期：2012-02-24 00:00:00

abstract：:The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine...

journal_title：Biochemical and biophysical research communications

authors： Vauzour D,Vafeiadou K,Spencer JP

更新日期：2007-10-19 00:00:00

abstract：:Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflam...

journal_title：Biochemical and biophysical research communications

authors： Chen WY,Chang YJ,Su CH,Tsai TH,Chen SD,Hsing CH,Yang JL

更新日期：2016-05-13 00:00:00

abstract：:We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum. Besides signals via growth factor/receptor, adhesion signals via integrin might be also enhanced by GD3. Here, roles of integ...

journal_title：Biochemical and biophysical research communications

authors： Ohkawa Y,Miyazaki S,Miyata M,Hamamura K,Furukawa K,Furukawa K

更新日期：2008-08-15 00:00:00

abstract：:Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewid...

journal_title：Biochemical and biophysical research communications

authors： Mao XQ,Kawai M,Yamashita T,Enomoto T,Dake Y,Sasaki S,Kataoka Y,Fukuzumi T,Endo K,Sano H,Aoki T,Kurimoto F,Adra CN,Shirakawa T,Hopkin JM

更新日期：2000-09-24 00:00:00

abstract：:The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

journal_title：Biochemical and biophysical research communications

authors： Duan X,He ZG

更新日期：2011-04-01 00:00:00

abstract：:ADAMTS13 cleaves multimeric von Willebrand factor (VWF) to regulate VWF-mediated thrombus formation. To search ADAMTS13 peptide sequences binding to VWF, a lambda-phage library expressing various peptides of ADAMTS13 on the surface was screened using VWF either immobilized or in solution under static condition. By the...

journal_title：Biochemical and biophysical research communications

authors： Moriki T,Maruyama IN,Igari A,Ikeda Y,Murata M

更新日期：2010-01-01 00:00:00

abstract：:A glycerol kinase (Gyk) knock-out (KO) mouse model permits improved understanding of glycerol kinase (GK) deficiency (GKD) pathogenesis, however, early death of affected mice limits its utility. The purpose of this work was to delay death of affected males to investigate thoroughly their phenotypes. An adenoviral vect...

journal_title：Biochemical and biophysical research communications

authors： Kuwada N,Nagano K,MacLennan N,Havens J,Kumar M,Dipple KM,McCabe ER

更新日期：2005-09-16 00:00:00

abstract：:It is commonly assumed that plants do not possess consciousness. Since the criterion for this assumption is usually human consciousness this assumption represents a top down attitude. It is obvious that plants are not animals and using animal criteria of consciousness will lead to its rejection in plants. However usin...

journal_title：Biochemical and biophysical research communications

authors： Calvo P,Baluška F,Trewavas A

更新日期：2020-10-17 00:00:00

abstract：:Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as well as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demonstrate here that complement...

journal_title：Biochemical and biophysical research communications

authors： McGuinness MC,Moser AB,Moser HW,Watkins PA

更新日期：1990-10-15 00:00:00

abstract：:To improve the expression of the genes transduced by retroviral vectors, we have constructed a U3-based retroviral vector and evaluated its effect on the expression of an insert from the internal promoter. The unique feature of the vector is that the transduced gene is inserted at the U3 region of the 3' long terminal...

journal_title：Biochemical and biophysical research communications

authors： Chen BF,Hsieh CL,Chen DS,Hwang LH

更新日期：1992-04-15 00:00:00

abstract：:Follicle-stimulating hormone (FSH) levels increase estrogen biosynthesis in obese menopausal women. Ovariectomized mice and 3T3-L1 cells were used to explore estrogen biosynthesis in the decline of ovarian function. After ovariectomy, lipid deposition, and FSH and estrogen levels changed, and feed intake increased sig...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Zhao G,Wen J,Tong W

更新日期：2018-01-15 00:00:00

abstract：:The self-induced endogenous elicitor isolated from potato having molecular weight 9200 was degraded with trifluoroacetic acid to determine the sugar composition. The requisite composition of the elicitor was estimated to be a 2:3:4:7 mixture of galactose, rhamnose, arabinose, and galacturonic acid. Furthermore, the st...

journal_title：Biochemical and biophysical research communications

authors： Monden T,Nakamura H,Murai A

更新日期：1995-10-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignancy with high cancer-associated mortality. Suppressing autophagy has been reported to promote the efficiency of chemotherapy in HCC. Daurisoline (DAS) is a constituent of Rhizoma Menispermi, and functions as a potential autophagy inhibitor to perform different cellular...

journal_title：Biochemical and biophysical research communications

authors： Xue L,Liu P

更新日期：2021-01-01 00:00:00

abstract：:Human endothelial cells were transiently transfected with E-Selectin which enabled us to study tumor cell/endothelial interactions following engagement of E-Selectin without the added complications of metabolic stimulation, morphological changes, and/or up regulation of other adhesion molecules due to cytokine inducti...

journal_title：Biochemical and biophysical research communications

authors： Merwin JR,Madri JA,Lynch M

更新日期：1992-11-30 00:00:00

abstract：:The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH. The addition of Benzo(a)pyrene, 3-Methyl cholanthrene, beta-Naphthoflavone and other aryl hydrocarbons during the inductio...

journal_title：Biochemical and biophysical research communications

authors： Dutta D,Ghosh DK,Mishra AK,Samanta TB

更新日期：1983-09-15 00:00:00

abstract：:Angiotensin II (Ang-II) has been shown to possess several atherogenic properties including its ability to induce macrophage-mediated oxidation of LDL and to form Ang-II-modified LDL which is taken up by macrophages at enhanced rate. Oxidized-LDL (Ox-LDL) is also taken up by macrophages at enhanced rate via several sca...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J

更新日期：1997-10-09 00:00:00

abstract：:Various unstable intermediate oxidation states have been postulated in the metabolic activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl pyridinium ion. We now report the first direct observation of these free radical intermediates by pulse radiolysis and flash photolysis. Studies are d...

journal_title：Biochemical and biophysical research communications

authors： Chacon JN,Chedekel MR,Land EJ,Truscott TG

更新日期：1987-04-29 00:00:00

abstract：:Nitrosporeusine A (NA) has been recently reported to exert anti-inflammatory and renal protective effects, but whether NA can attenuate sepsis-associated acute kidney injury (AKI) has not yet been reported. In this study, our results found that cecal ligation and puncture (CLP) reduced renal PGC-1α expression and indu...

journal_title：Biochemical and biophysical research communications

authors： Zhao Y,Nie M,Xu P,Li H,Xu L,Cheng XQ,Lei YQ

更新日期：2019-07-30 00:00:00

abstract：:Thymosin beta15 (Tbeta15) is a pleiotropic factor which exerts multiple roles in the development of nervous system and brain diseases. In this study, we found that the expressions of Tbeta15 mRNA and protein were substantially increased in several brain regions including hippocampal formation and cerebral cortex, foll...

journal_title：Biochemical and biophysical research communications

authors： Kim YW,Kim Y,Kim EH,Koh D,Sun W,Kim H

更新日期：2008-07-11 00:00:00

abstract：:A human cell line established from a patient of an acute monocytic leukemia (THP-1) retained an ability to synthesize and secrete plasma apolipoprotein E like protein. The protein was identified with monospecific antibody raised against human plasma apolipoprotein E. The cells also secreted lipoprotein lipase (EC 3.1....

journal_title：Biochemical and biophysical research communications

authors： Tajima S,Hayashi R,Tsuchiya S,Miyake Y,Yamamoto A

更新日期：1985-01-16 00:00:00

abstract：:Two ATP-competitive inhibitors-4,5,6,7-tetrabromo-benzotriazole (TBBt) and 4,5,6,7-tetrabromo-benzimidazole (TBBz) have been shown to decrease activity of CK2 holoenzyme. Surprisingly it occurs that TBBz contrary to TBBt does not inhibit free catalytic subunit CK2 [Formula: see text]. Both inhibitors are virtually ina...

journal_title：Biochemical and biophysical research communications

authors： Zień P,Abramczyk O,Domańska K,Bretner M,Szyszka R

更新日期：2003-12-19 00:00:00

abstract：:The interaction of adrenodoxin (Adx) and NADPH cytochrome P450 reductase (CPR) with human microsomal steroidogenic cytochrome P450s was studied. It is found that Adx, mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450s: full length CYP17, truncated CYP17, and trunc...

journal_title：Biochemical and biophysical research communications

authors： Pechurskaya TA,Harnastai IN,Grabovec IP,Gilep AA,Usanov SA

更新日期：2007-02-16 00:00:00