Abstract:
:Various unstable intermediate oxidation states have been postulated in the metabolic activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl pyridinium ion. We now report the first direct observation of these free radical intermediates by pulse radiolysis and flash photolysis. Studies are described of various reactions of such species, in particular with dopamine whose autoxidation to dopamine quinone is reported to be potentiated by 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Chacon JN,Chedekel MR,Land EJ,Truscott TGdoi
10.1016/s0006-291x(87)80057-8subject
Has Abstractpub_date
1987-04-29 00:00:00pages
957-64issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(87)80057-8journal_volume
144pub_type
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