Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics.

abstract：:Matrix vesicles (MVs) are cell-derived membranous entities crucial for mineral formation in the extracellular matrix. One of the dominant groups of constitutive proteins present in MVs, recognised as regulators of mineralization in norm and pathology, are annexins. In this report, besides the annexins already describe...

journal_title：Biochemical and biophysical research communications

authors： Cmoch A,Strzelecka-Kiliszek A,Palczewska M,Groves P,Pikula S

更新日期：2011-09-09 00:00:00

abstract：:Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is ubiquitylated and degraded by the proteasome pathway in human cells. Firstly, the fate of Cdc45 protein after induction of terminal diff...

journal_title：Biochemical and biophysical research communications

authors： Pollok S,Grosse F

更新日期：2007-11-03 00:00:00

abstract：:C-C chemokine receptor 7 (CCR7) and its ligands CCL19 contributes to the directional migration of certain cancer cell lines, but its role in the migration of BMSCs remains vague. The aim of this study was to determine the possible interaction between CCL19-induced conditions and matrix metalloproteinases-9 (MMP9) expr...

journal_title：Biochemical and biophysical research communications

authors： Zhang W,Tu G,Lv C,Long J,Cong L,Han Y

更新日期：2014-08-22 00:00:00

abstract：:Two isoforms of the src-family tyrosine kinase p59fyn have been shown to arise through alternative splicing of exon 7 of the fyn gene. These isoforms have been designated fynT, expressed in hematopoietic cells, and fynB, expressed in the brain. Here, we describe a novel isoform, fynDelta7, in which exon 7 is absent. F...

journal_title：Biochemical and biophysical research communications

authors： Goldsmith JF,Hall CG,Atkinson TP

更新日期：2002-11-08 00:00:00

abstract：:DR4, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, is a key element in the extrinsic pathway of TRAIL/TRAIL receptor-related apoptosis that exerts a preferential toxic effect against tumor cells. However, TRAIL and DR4 are expressed in various normal cells, and recent studies indicate tha...

journal_title：Biochemical and biophysical research communications

authors： Kang MS,Lee SK,Park CS,Kang JH,Bae SH,Yu SL

更新日期：2008-11-14 00:00:00

abstract：:To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions. One of these, D88, covers residues 1-88 and represents almost the entire headpiece; the othe...

journal_title：Biochemical and biophysical research communications

authors： Saeed T,Ip W

更新日期：1989-12-29 00:00:00

abstract：:We compared the intracellular signalling pathways through Ret tyrosine kinase activated by glial cell line-derived neurotrophic factor (GDNF), multiple endocrine neoplasia (MEN) 2A, or MEN 2B mutation. Tyrosine phosphorylation of Grb2-associated binder-1 (Gab1) and activation of phosphatidylinositol 3-kinase (PI 3-kin...

journal_title：Biochemical and biophysical research communications

authors： Murakami H,Iwashita T,Asai N,Shimono Y,Iwata Y,Kawai K,Takahashi M

更新日期：1999-08-19 00:00:00

abstract：:Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of <6 mg/dl (Stamp et al., 2012) [1]. Our study aimed to identify the molecular basis for this observation. We used a fluorimetric assay to determine the impact of furosemide and ...

journal_title：Biochemical and biophysical research communications

authors： Knake C,Stamp L,Bahn A

更新日期：2014-09-12 00:00:00

abstract：:A gene library of Anaerocellum thermophilum Z-1320 was constructed in Escherichia coli using plasmid pUC18. Clones were selected by screening for hydrolysis of CMC, MU-Cel, lichenan and xylan. Recombinant clones expressing two beta-1,4-glucanases and two different xylanases were obtained. Both beta-1,4-glucanases were...

journal_title：Biochemical and biophysical research communications

authors： Bolshakova EV,Ponomariev AA,Novikov AA,Svetlichnyi VA,Velikodvorskaya GA

更新日期：1994-07-29 00:00:00

abstract：:In eukaryotes, the poly(A)-binding protein (PABP) is one of the important factors for initiation of messenger RNA translation. PABP activity is regulated by the PABP-interacting proteins (Paips), which include Paip1, Paip2A, and Paip2B. Human Paip1 has three different isoforms. Here, we report the crystal structure of...

journal_title：Biochemical and biophysical research communications

authors： Lei J,Mesters JR,von Brunn A,Hilgenfeld R

更新日期：2011-05-20 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II) is a potent mitogen for cells in culture. The H19 gene is a developmentally regulated gene with putative tumor suppressor activity, and loss of H19 expression may be involved in tumorigenesis. The H19 gene is closely linked to the human IGF-II gene (IGF2) on chromosome 11p15.5 an...

journal_title：Biochemical and biophysical research communications

authors： Kiess W,Paquette J,Koepf G,Wolf E,Deal C

更新日期：1999-02-16 00:00:00

abstract：:Human prostasin was recently identified as a potential regulator of epithelial sodium channel (ENaC) function. Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 prefer...

journal_title：Biochemical and biophysical research communications

authors： Shipway A,Danahay H,Williams JA,Tully DC,Backes BJ,Harris JL

更新日期：2004-11-12 00:00:00

abstract：:Based on our recent observation that enhanced IL-18 expression positively correlates with malignant skin tumors, such as SCC and melanoma, we examined the possible role of UVB, known to be associated with skin cancer development, in the enhancement of IL-18 production using primary human epidermal keratinocytes and hu...

journal_title：Biochemical and biophysical research communications

authors： Cho D,Seung Kang J,Hoon Park J,Kim YI,Hahm E,Lee J,Yang Y,Jeon J,Song H,Park H,Kim T,Pang S,Kim CW,Il Hwang Y,Jae Lee W

更新日期：2002-10-25 00:00:00

abstract：:Mutations in the WNK1 and WNK4 genes result in an inherited hypertensive disease, pseudohypoaldosteronism type II (PHAII). Recently, the KLHL3 and Cullin3 genes were also identified as responsible genes for PHAII. Although we have reported that WNK4 is a substrate for the KLHL3-Cullin3 E3 ligase complex, it is not cle...

journal_title：Biochemical and biophysical research communications

authors： Takahashi D,Mori T,Wakabayashi M,Mori Y,Susa K,Zeniya M,Sohara E,Rai T,Sasaki S,Uchida S

更新日期：2013-08-02 00:00:00

abstract：:Strong temperature dependent low angle X-ray scattering by trifluoroethanol- and hexafluoro-2-propanol-water mixtures was observed in conditions commonly used in NMR work on peptides. At least two types of molecular effects may contribute to the observed scattering: formation of clathrate hydrate-like aggregates of al...

journal_title：Biochemical and biophysical research communications

authors： Kuprin S,Gräslund A,Ehrenberg A,Koch MH

更新日期：1995-12-26 00:00:00

abstract：:The forced expression of the catalytic subunit of human telomerase, hTERT, produces telomerase activity, allows telomere maintenance, and extends the cellular life span of IMR90 human lung fibroblasts. The mutation D869A abolishes both the catalytic activity of hTERT and its ability to extend cellular life span, demon...

journal_title：Biochemical and biophysical research communications

authors： Ouellette MM,Aisner DL,Savre-Train I,Wright WE,Shay JW

更新日期：1999-01-27 00:00:00

abstract：:The nucleotide sequence of the promoter region of the melibiose operon of E. coli was determined. Consensus sequences for the -35 region, the Pribnow box and the binding site for cyclic AMP receptor protein were found in this region. The possible secondary structure of this DNA region was very similar to that of the p...

journal_title：Biochemical and biophysical research communications

authors： Shimamoto T,Yazyu H,Futai M,Tsuchiya T

更新日期：1984-05-31 00:00:00

abstract：:Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We investigated the impact of spinal CREB protein levels and phosphoryl...

journal_title：Biochemical and biophysical research communications

authors： Niederberger E,Ehnert C,Gao W,Coste O,Schmidtko A,Popp L,Gall CV,Korf HW,Tegeder I,Geisslinger G

更新日期：2007-10-12 00:00:00

abstract：:Hemin (iron protoporphyrin IX) is a necessary component of many proteins, functioning either as a cofactor or an intracellular messenger. Hemoproteins have diverse functions, such as transportation of gases, gas detection, chemical catalysis and electron transfer. Stanniocalcin 1 (STC1) is a protein involved in respir...

journal_title：Biochemical and biophysical research communications

authors： Westberg JA,Jiang J,Andersson LC

更新日期：2011-06-03 00:00:00

abstract：:Osteogenic protein-1 (OP-1) is a member of the bone morphogenetic protein subfamily of the transforming growth factor-beta (TGF-beta) superfamily. Since members of the TGF-beta superfamily have a role in tissue development the distribution of OP-1 in developing human embryos (gestational age 5-14 weeks) was examined b...

journal_title：Biochemical and biophysical research communications

authors： Vukicevic S,Latin V,Chen P,Batorsky R,Reddi AH,Sampath TK

更新日期：1994-01-28 00:00:00

abstract：:Pyrrolidine dithiocarbamate (PDTC) is a metal chelating compound that can exert either pro-oxidant or antioxidant effects in different situations. Several studies demonstrate that it can inhibit cyclooxygenase-2 (COX-2) expression, which may be due to its antioxidant activity. Here, we found that PDTC rather increased...

journal_title：Biochemical and biophysical research communications

authors： Lee JE,Kim KM,Cho JW,Suh SI,Suh MH,Kwon TK,Park JW,Bae JH,Song DK,Cho CH,Bae I,Baek WK

更新日期：2002-10-25 00:00:00

abstract：:The human elafin gene was cloned and its entire nucleotide sequence was determined to deduce the amino acid sequence for the precursor of elafin, an elastase-specific inhibitor. The gene spans approximately 1.7 kb and is divided into 3 exons. The gene product preproelafin consists of 117 amino acids: the initiator Met...

journal_title：Biochemical and biophysical research communications

authors： Saheki T,Ito F,Hagiwara H,Saito Y,Kuroki J,Tachibana S,Hirose S

更新日期：1992-05-29 00:00:00

abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

更新日期：2017-12-09 00:00:00

abstract：:Apoaequorin was targeted to the cytosol, nucleus, and endoplasmic reticulum of HeLa cells in order to determine the effect of Ca(2+) release from the ER on protein degradation. In resting cells apoaequorin had a rapid half-life (ca. 20-30 min) in the cytosol or nucleus, but was relatively stable for up to 24 h in the ...

journal_title：Biochemical and biophysical research communications

authors： Jeffery J,Kendall JM,Campbell AK

更新日期：2000-02-24 00:00:00

abstract：:We have previously shown that mammalian brain crude extracts contained two classes of stable microtubules: "cold stable" and "super-stable" microtubules. We now find that both species are generated by a single protein factor (STOP protein) in a dose dependent manner. These results show that STOP protein action can be ...

journal_title：Biochemical and biophysical research communications

authors： Job D,Rauch CT,Margolis RL

更新日期：1987-10-14 00:00:00

abstract：:Tissue transglutaminase (tTgase) contributes to the organisation of the basement membrane and is therefore thought to be important for the integrity and stability of the vessel wall. In the present study, we hypothesised that the HMG-CoA reductase inhibitor atorvastatin may up-regulate the tTgase expression in endothe...

journal_title：Biochemical and biophysical research communications

authors： Soehnlein O,Eskafi S,Schmeisser A,Kloos H,Daniel WG,Garlichs CD

更新日期：2004-09-10 00:00:00

abstract：:In our previous studies, we have demonstrated that a stretch of amino-acid sequences identified from Arabidopsis ribosomal S6 kinase 1 (AtS6K1) provided a plant version of the TOS (TOR-signaling) motif, mediating the interaction with the Raptor protein in the TOR (Target of Rapamycin) kinase complex. Here we report th...

journal_title：Biochemical and biophysical research communications

authors： Son O,Kim S,Kim D,Hur YS,Kim J,Cheon CI

更新日期：2018-06-27 00:00:00

abstract：:A simple fluorescence-based assay was developed for the rapid screening of potential cytotoxic compounds generated by combinatorial chemistry. The assay is based on detection of nuclear green fluorescent protein (GFP) staining of a human cervical cancer cell line (HeLa) carrying an integrated histone H2B-GFP fusion ge...

journal_title：Biochemical and biophysical research communications

authors： Montoya J,Varela-Ramirez A,Estrada A,Martinez LE,Garza K,Aguilera RJ

更新日期：2004-12-24 00:00:00

abstract：:Aggregation of the amyloid beta (Abeta) peptide yields both fibrillar precipitates and soluble oligomers, and is associated with Alzheimer's disease (AD). In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation. However, less is known about their interactions with the soluble oligomers, which are...

journal_title：Biochemical and biophysical research communications

authors： Garai K,Sengupta P,Sahoo B,Maiti S

更新日期：2006-06-23 00:00:00

abstract：:Although N-acetyl-L-aspartate (NAA) has been shown to be important to myelin synthesis and osmotic regulation, the biological rationale for the high levels of NAA found in the brain remains unknown. Here, a human astroglial cell line (STTG) was treated with NAA and stimulated with ionomycin, ionomycin/PMA, or IL-1beta...

journal_title：Biochemical and biophysical research communications

authors： Rael LT,Thomas GW,Bar-Or R,Craun ML,Bar-Or D

更新日期：2004-07-02 00:00:00