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High concentrations of STOP protein induce a microtubule super-stable state.

Abstract：

:We have previously shown that mammalian brain crude extracts contained two classes of stable microtubules: "cold stable" and "super-stable" microtubules. We now find that both species are generated by a single protein factor (STOP protein) in a dose dependent manner. These results show that STOP protein action can be extreme, inducing resistance to -80 degrees C or to sonication and that no other factor seems to be required to account for the various subclasses of highly stable microtubules in brain. Finally, the rapid procedure described for the preparation of purified "super-stable microtubules" should be useful for the obtention of fractions with high STOP protein activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Job D,Rauch CT,Margolis RL

doi

10.1016/0006-291x(87)91129-6

subject

Has Abstract

pub_date

1987-10-14 00:00:00

pages

429-34

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)91129-6

journal_volume

148

pub_type

杂志文章

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